eukaryotic translation initiation factor 4A, isoform 2

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Synonym

eIF-4A-II, EIF4A, DDX2B, eIF4A-II, BM-010, EIF4A2, Eukaryotic initiation factor 4A-II, ATP-dependent RNA helicase eIF4A-2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1060.70 cerebellum:4647.10 brain stem:- corpus callosum/glia:991.50 pineal gland:741.70 peripheral nerve:797.50 spine:673.80 retina:474.60 eye:311.50 artery/aorta:419.70 vein:999.70 lymphnode:202.20 peripheral blood:619.40 spleen:926.40 thymus:2216 bone marrow:216.50 adipose:2379.70 bone:1292.30 skin:504
GeneChip cerebrum:11.61 cerebellum:12.25 brain stem:11.46 corpus callosum/glia:10.68 pineal gland:- peripheral nerve:11.34 spine:11.07 retina:- eye:- artery/aorta:10.81 vein:10.69 lymphnode:10.85 peripheral blood:- spleen:10.97 thymus:11.16 bone marrow:10.06 adipose:10.73 bone:- skin:10.51
CAGE cerebrum:6.32 cerebellum:- brain stem:6.01 corpus callosum/glia:5.42 pineal gland:6.10 peripheral nerve:- spine:6.00 retina:- eye:- artery/aorta:5.67 vein:5.46 lymphnode:5.17 peripheral blood:- spleen:5.48 thymus:5.11 bone marrow:- adipose:5.48 bone:- skin:-
RNA-seq cerebrum:8.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:8.10 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:6.34 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:4128.30 placenta:674 prostate:461.80 ovary:708 testis:640.30 heart:1417.70 muscle:1245.60 esophagus:2056.90 stomach:2294.20 intestine:1911.50 colon:610.50     liver/hepato:369.40        lung:845.50    bladder:4270.80 kidney:1039.70 pituitary:1739.70 thyroid/parathyroid:818.70 adrenal gland:2488.60 pancreas:782.40 breast:316 salivary:-
GeneChip uterus:11.39 placenta:10.46 prostate:11.47 ovary:11.62 testis:10.67 heart:10.93 muscle:11.44 esophagus:10.47 stomach:10.81 intestine:10.93 colon:10.34 liver/hepato:10.21 lung:10.81 bladder:- kidney:10.77 pituitary:11.79 thyroid/parathyroid:11.16 adrenal gland:10.86 pancreas:10.99 breast:10.55 salivary:10.73
CAGE uterus:5.90 placenta:5.51 prostate:6.04 ovary:6.10 testis:5.64 heart:5.75 muscle:6.17 esophagus:5.84 stomach:- intestine:5.62 colon:5.50     liver/hepato:5.08    lung:5.55 bladder:6.23 kidney:5.36 pituitary:6.66 thyroid/parathyroid:6.19 adrenal gland:- pancreas:5.89 breast:5.56 salivary:5.48
RNA-seq uterus:- placenta:- prostate:8.52 ovary:8.21 testis:7.86 heart:6.75 muscle:8.07 esophagus:- stomach:- intestine:- colon:8.76     liver/hepato:5.76        lung:7.84    bladder:- kidney:7.26 pituitary:- thyroid/parathyroid:8.51 adrenal gland:7.18 pancreas:- breast:7.02 salivary:-

Gene Information

IDs

Refseq ID NM_001967
Gene ID 1974
Unigene ID Hs.518475
Probe set ID 200912_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000156976
GTEx ID ENSG00000156976

Orthologous Gene

Mouse[3]  NM_001123037, NM_001123038, NM_013506
Rat[3]  NM_001123037, NM_001123038, NM_013506

Chromosomal Region

3q27.3  [186,500,994  -  186,507,689]

Gene Family (Interpro ID)

IPR014001  DEAD-like helicase, N-terminal
IPR014021  Helicase, superfamily 1/2, ATP-binding domain

Link to Pubmed  (Pubmed ID)

8125298
8449919
8521730
11172724
11408474
11922617
12477932
12588972
15047060
15489334
15946665
16014927
16169070
16567544
17353931
17643375
18250159
18593934
18976975
19034380
19596686
19615732
20360068
20639865
20972266
21110914
21139048
21427765
21890473
21900206
21906983
21963094
21987572
22053931
22360420
22505724
22589333
22759308
22939629
22944692
22990118
23000965
23383273
23463506
23559250
23824909
23867391
24105470
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0044267  cellular protein metabolic process
GO:0019221  cytokine-mediated signaling pathway
GO:0010467  gene expression
GO:0016071  mRNA metabolic process
GO:0000288  nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289  nuclear-transcribed mRNA poly(A) tail shortening
GO:0006446  regulation of translational initiation
GO:0016070  RNA metabolic process
GO:0006412  translation
GO:0006413  translational initiation
GO:0019048  virus-host interaction

Cellular Component

GO:0005829  cytosol
GO:0016281  eukaryotic translation initiation factor 4F complex

Molecular Function

GO:0005524  ATP binding
GO:0008026  ATP-dependent helicase activity
GO:0004386  helicase activity
GO:0005515  protein binding
GO:0003743  translation initiation factor activity