eukaryotic translation initiation factor 5

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Synonym

eIF-5, EIF-5A, Eukaryotic translation initiation factor 5, EIF5, eukaryotic translation initiation factor 5

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:378.10 cerebellum:466 brain stem:- corpus callosum/glia:145.80 pineal gland:- peripheral nerve:122.70 spine:- retina:118.60 eye:188.10 artery/aorta:119.90 vein:199.90 lymphnode:374.10 peripheral blood:109.30 spleen:113.40 thymus:167.50 bone marrow:78.70 adipose:80.70 bone:268.70 skin:235.20
GeneChip cerebrum:9.95 cerebellum:9.78 brain stem:10.05 corpus callosum/glia:9.71 pineal gland:- peripheral nerve:9.76 spine:9.89 retina:- eye:- artery/aorta:9.08 vein:8.93 lymphnode:9.41 peripheral blood:- spleen:9.70 thymus:9.81 bone marrow:9.45 adipose:9.58 bone:- skin:9.33
CAGE cerebrum:4.57 cerebellum:- brain stem:4.40 corpus callosum/glia:4.10 pineal gland:3.93 peripheral nerve:- spine:4.26 retina:- eye:- artery/aorta:4.18 vein:3.96 lymphnode:4.22 peripheral blood:- spleen:4.31 thymus:4.08 bone marrow:- adipose:4.01 bone:- skin:-
RNA-seq cerebrum:3.36 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.29 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.12 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:492.10 placenta:229.50 prostate:112.60 ovary:37.30 testis:636 heart:498.10 muscle:261.20 esophagus:- stomach:191.20 intestine:194.40 colon:186.60     liver/hepato:411.70        lung:317.70    bladder:502.40 kidney:207.90 pituitary:116 thyroid/parathyroid:- adrenal gland:152.40 pancreas:222.30 breast:167.30 salivary:-
GeneChip uterus:9.47 placenta:9.62 prostate:9.70 ovary:9.74 testis:10.81 heart:9.57 muscle:9.78 esophagus:9.95 stomach:9.64 intestine:9.35 colon:9.60 liver/hepato:10.08 lung:9.66 bladder:- kidney:9.67 pituitary:9.34 thyroid/parathyroid:9.92 adrenal gland:9.60 pancreas:9.27 breast:9.75 salivary:9.48
CAGE uterus:4.04 placenta:4.27 prostate:4.01 ovary:3.78 testis:4.62 heart:4.16 muscle:4.37 esophagus:3.89 stomach:- intestine:4.30 colon:4.23     liver/hepato:5.00    lung:4.19 bladder:3.96 kidney:4.10 pituitary:4.42 thyroid/parathyroid:4.46 adrenal gland:- pancreas:4.22 breast:4.41 salivary:4.28
RNA-seq uterus:- placenta:- prostate:0.42 ovary:0.30 testis:2.59 heart:0.28 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.41     liver/hepato:0.84        lung:0.87    bladder:- kidney:1.29 pituitary:- thyroid/parathyroid:0.64 adrenal gland:0.54 pancreas:- breast:0.86 salivary:-

Gene Information

IDs

Refseq ID NM_183004
Gene ID 1983
Unigene ID Hs.433702
Probe set ID 208705_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100664
GTEx ID ENSG00000100664

Orthologous Gene

Mouse[16]  NM_173363, NM_178041
Rat[16]  NM_173363, NM_178041

Chromosomal Region

14q32.32  [103,800,493  -  103,811,359]

Gene Family (Interpro ID)

IPR016024  Armadillo-type fold
IPR003307  eIF4-gamma/eIF5/eIF2-epsilon

Link to Pubmed  (Pubmed ID)

8663286
9395514
9973622
10805737
10982835
11092890
11230166
11331597
11861906
12477932
12569173
14702039
15489334
16227438
16584190
16781736
17081983
17207965
18029348
19738201
19953087
20562859
21139048
21832049
21890473
21906983
21963094
21988832
22062548
22412018
22813744
22863883
22939629
23222517
23293029
24319994
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0044267  cellular protein metabolic process
GO:0010467  gene expression
GO:0006184  GTP catabolic process
GO:0006446  regulation of translational initiation
GO:0016070  RNA metabolic process
GO:0006412  translation
GO:0006413  translational initiation

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol

Molecular Function

GO:0005525  GTP binding
GO:0003924  GTPase activity
GO:0008135  translation factor activity, nucleic acid binding
GO:0003743  translation initiation factor activity