alpha-2-macroglobulin

Synonym

alpha-2-macroglobulin, Alpha-2-macroglobulin precursor, CPAMD5, A2M, S863-7, alpha 2-macroglobulin (A2M), FWP007, alpha 2M, Alpha-2-M, DKFZp779B086

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:302.20

cerebellum:125.90

brain stem:-

corpus callosum/glia:87.50

pineal gland:296.70

peripheral nerve:1410.90

spine:673.80

retina:949.10

eye:211.60

artery/aorta:60

vein:-

lymphnode:1445.80

peripheral blood:983.80

spleen:756.30

thymus:231.90

bone marrow:78.70

adipose:927.70

bone:627

skin:388.80

GeneChip

cerebrum:9.23

cerebellum:7.75

brain stem:9.61

corpus callosum/glia:9.68

pineal gland:-

peripheral nerve:10.17

spine:9.75

retina:-

eye:-

artery/aorta:11.44

vein:10.76

lymphnode:9.34

peripheral blood:-

spleen:10.53

thymus:8.21

bone marrow:7.33

adipose:10.87

bone:-

skin:9.64

CAGE

cerebrum:4.38

cerebellum:-

brain stem:5.10

corpus callosum/glia:5.45

pineal gland:4.70

peripheral nerve:-

spine:4.94

retina:-

eye:-

artery/aorta:6.52

vein:5.18

lymphnode:4.66

peripheral blood:-

spleen:5.94

thymus:3.47

bone marrow:-

adipose:6.58

bone:-

skin:-

RNA-seq

cerebrum:5.08

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:8.28

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:8.45

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:1038.90

placenta:776

prostate:664.60

ovary:149.10

testis:242.30

heart:562

muscle:20.10

esophagus:-

stomach:318.60

intestine:421.20

colon:1153.20

liver/hepato:2491.10

lung:1388.10

bladder:125.60

kidney:228.70

pituitary:232

thyroid/parathyroid:491.20

adrenal gland:253.90

pancreas:62.20

breast:102.20

salivary:-

GeneChip

uterus:10.62

placenta:9.99

prostate:10.07

ovary:9.82

testis:8.31

heart:10.96

muscle:9.07

esophagus:9.05

stomach:10.51

intestine:10.41

colon:10.49

liver/hepato:11.52

lung:12.63

bladder:-

kidney:10.24

pituitary:9.80

thyroid/parathyroid:9.93

adrenal gland:10.79

pancreas:9.22

breast:10.34

salivary:9.13

CAGE

uterus:6.19

placenta:5.66

prostate:6.63

ovary:5.91

testis:4.89

heart:6.02

muscle:4.72

esophagus:5.91

stomach:-

intestine:5.33

colon:5.28

liver/hepato:7.49

lung:7.06

bladder:6.41

kidney:5.86

pituitary:5.26

thyroid/parathyroid:5.44

adrenal gland:-

pancreas:4.77

breast:5.61

salivary:4.90

RNA-seq

uterus:-

placenta:-

prostate:8.32

ovary:7.03

testis:7.40

heart:7.70

muscle:5.75

esophagus:-

stomach:-

intestine:-

colon:8.46

liver/hepato:10.01

lung:10.23

bladder:-

kidney:7.49

pituitary:-

thyroid/parathyroid:6.36

adrenal gland:8.28

pancreas:-

breast:7.69

salivary:-

IDs

Refseq ID	NM_000014
Gene ID	2
Unigene ID	Hs.212838
Probe set ID	217757_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000175899
GTEx ID	ENSG00000175899

Orthologous Gene

Mouse[1]	NM_175628
Rat [0]

Chromosomal Region

12p13.31 [9,220,260 - 9,268,825]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0001869	negative regulation of complement activation, lectin pathway
GO:0030168	platelet activation
GO:0002576	platelet degranulation
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0048863	stem cell differentiation

Cellular Component

GO:0005829	cytosol
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0031093	platelet alpha granule lumen

Molecular Function

GO:0019899	enzyme binding
GO:0019838	growth factor binding
GO:0019966	interleukin-1 binding
GO:0019959	interleukin-8 binding
GO:0005515	protein binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0043120	tumor necrosis factor binding

alpha-2-macroglobulin

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function