folliculin

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Synonym

BHD skin lesion fibrofolliculoma protein, folliculin, BHD, FLCL, FLCN, Birt-Hogg-Dube syndrome protein, Folliculin, MGC23445, MGC17998

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:17.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:37.80 thymus:- bone marrow:19.70 adipose:80.70 bone:12.80 skin:4.80
GeneChip nodata
CAGE cerebrum:0.35 cerebellum:- brain stem:0.37 corpus callosum/glia:0.07 pineal gland:0 peripheral nerve:- spine:0.17 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:2.43 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.05 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.27 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:25.50 prostate:22.50 ovary:37.30 testis:13 heart:25.50 muscle:- esophagus:- stomach:21.20 intestine:- colon:33.90     liver/hepato:42.20        lung:4.90    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:18.60 salivary:-
GeneChip nodata
CAGE uterus:0.10 placenta:0.08 prostate:0 ovary:0.14 testis:0.13 heart:0.08 muscle:0 esophagus:0.09 stomach:- intestine:0 colon:0.08     liver/hepato:0    lung:0.17 bladder:0.09 kidney:0 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:3.40 ovary:2.85 testis:2.90 heart:2.07 muscle:2.61 esophagus:- stomach:- intestine:- colon:2.17     liver/hepato:1.87        lung:2.48    bladder:- kidney:2.79 pituitary:- thyroid/parathyroid:3.55 adrenal gland:2.93 pancreas:- breast:2.86 salivary:-

Gene Information

IDs

Refseq ID NM_144997
Gene ID 201163
Unigene ID Hs.513975
Probe set ID -
Ensembl ID ENSG00000154803
GTEx ID ENSG00000154803

Orthologous Gene

Mouse[2]  NM_146018
Rat[1]  NM_199390

Chromosomal Region

17p11.2  [17,115,526  -  17,140,502]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

11526515
11533913
12204536
12471204
12477932
12746401
12843323
12907635
14627671
14702039
14961590
15489334
15579035
15657874
15852235
15956655
16344560
16636660
16870330
17028174
17149965
17207965
17496196
18029348
18206534
18234728
18403135
18505456
18573707
18579543
18663353
18709329
19116017
19234517
19327534
19483054
20227563
20301695
20413710
20522427
20562859
20618353
21079084
21139048
21209915
21258407
21412933
21496834
21538689
21832049
21890473
22146830
22190034
22211584
22446046
22709692
22965878
22977732
22990118
23077212
23139756
23150719
23155228
23264078
23414156
23416984
23784378
23824909
23874397
24095279

Gene Ontology  (GO ID)

Biological Process

GO:0007043  cell-cell junction assembly
GO:0030097  hemopoiesis
GO:0001701  in utero embryonic development
GO:0030308  negative regulation of cell growth
GO:0030336  negative regulation of cell migration
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0010629  negative regulation of gene expression
GO:0010823  negative regulation of mitochondrion organization
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0035024  negative regulation of Rho protein signal transduction
GO:0032007  negative regulation of TOR signaling pathway
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0043065  positive regulation of apoptosis
GO:0045785  positive regulation of cell adhesion
GO:0010628  positive regulation of gene expression
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0032008  positive regulation of TOR signaling pathway
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032465  regulation of cytokinesis
GO:0035065  regulation of histone acetylation
GO:0001932  regulation of protein amino acid phosphorylation
GO:0032006  regulation of TOR signaling pathway
GO:0006950  response to stress
GO:0031929  TOR signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0030496  midbody
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005515  protein binding
GO:0032403  protein complex binding