EPH receptor A4

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Synonym

Hek8, EPH receptor A4, EPHA4, HEK8, Receptor protein-tyrosine kinase HEK8, Ephrin type-A receptor 4 precursor, EphA4, TYRO1, Tyrosine-protein kinase receptor SEK, SEK

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:302.20 cerebellum:138.50 brain stem:- corpus callosum/glia:87.50 pineal gland:- peripheral nerve:- spine:- retina:- eye:64.60 artery/aorta:60 vein:- lymphnode:10.10 peripheral blood:- spleen:56.70 thymus:25.80 bone marrow:59 adipose:- bone:25.60 skin:144
GeneChip cerebrum:7.91 cerebellum:7.59 brain stem:6.29 corpus callosum/glia:6.05 pineal gland:- peripheral nerve:5.64 spine:6.29 retina:- eye:- artery/aorta:6.51 vein:6.50 lymphnode:6.36 peripheral blood:- spleen:6.29 thymus:5.94 bone marrow:5.46 adipose:6.74 bone:- skin:7.01
CAGE cerebrum:3.56 cerebellum:- brain stem:2.13 corpus callosum/glia:2.45 pineal gland:1.50 peripheral nerve:- spine:1.96 retina:- eye:- artery/aorta:2.51 vein:1.95 lymphnode:1.85 peripheral blood:- spleen:1.15 thymus:1.24 bone marrow:- adipose:2.55 bone:- skin:-
RNA-seq cerebrum:4.17 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.68 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:3.60 prostate:78.90 ovary:372.60 testis:103.80 heart:76.60 muscle:- esophagus:- stomach:- intestine:32.40 colon:33.90     liver/hepato:-        lung:29.30    bladder:- kidney:72.80 pituitary:116 thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:18.60 salivary:-
GeneChip uterus:6.29 placenta:4.80 prostate:6.56 ovary:6.55 testis:7.67 heart:7.30 muscle:5.86 esophagus:6.47 stomach:6.57 intestine:5.64 colon:6.02 liver/hepato:5.44 lung:6.17 bladder:- kidney:6.88 pituitary:5.43 thyroid/parathyroid:7.47 adrenal gland:6.43 pancreas:4.99 breast:7.18 salivary:6.05
CAGE uterus:2.82 placenta:0.81 prostate:2.44 ovary:2.23 testis:3.54 heart:2.61 muscle:1.52 esophagus:2.10 stomach:- intestine:1.63 colon:2.02     liver/hepato:0.26    lung:1.84 bladder:1.83 kidney:1.85 pituitary:0.59 thyroid/parathyroid:2.56 adrenal gland:- pancreas:1.21 breast:1.92 salivary:1.67
RNA-seq uterus:- placenta:- prostate:2.24 ovary:2.12 testis:3.16 heart:2.17 muscle:0.91 esophagus:- stomach:- intestine:- colon:2.23     liver/hepato:0.25        lung:0.84    bladder:- kidney:1.65 pituitary:- thyroid/parathyroid:2.65 adrenal gland:1.79 pancreas:- breast:1.67 salivary:-

Gene Information

IDs

Refseq ID NM_004438
Gene ID 2043
Unigene ID Hs.371218
Probe set ID 206114_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000116106
GTEx ID ENSG00000116106

Orthologous Gene

Mouse[2]  NM_007936
Rat[1]  NM_001162411

Chromosomal Region

2q36.1  [222,282,747  -  222,438,922]

Gene Family (Interpro ID)

IPR001090  Ephrin receptor, ligand binding
IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR008979  Galactose-binding domain-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001660  Sterile alpha motif
IPR010993  Sterile alpha motif homology
IPR013761  Sterile alpha motif-type
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR016257  Tyrosine-protein kinase, ephrin receptor
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7898931
8125298
8622893
8755474
8889548
9267020
9345045
9484836
9530499
9576626
9632142
10207129
10366629
10607706
10730216
11085874
11128993
11256076
11336673
12084815
12383247
12477932
12496762
12761826
12775584
14576067
15313894
15489334
15688035
15994237
16365308
16540516
16574431
16965393
17143272
17847007
18628988
18695888
18790757
18837080
19949912
20098747
20100581
20678482
21186356
21444754
21873938
21875946
21890473
21935409
21942715
22273509
22318127
22807579
22922411
22939624
23000965
23429488
23776197
23959867

Gene Ontology  (GO ID)

Biological Process

GO:0007628  adult walking behavior
GO:0007155  cell adhesion
GO:0021957  corticospinal tract morphogenesis
GO:0008347  glial cell migration
GO:0008045  motor axon guidance
GO:0048681  negative regulation of axon regeneration
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0050775  positive regulation of dendrite morphogenesis
GO:0043507  positive regulation of JUN kinase activity
GO:0046777  protein amino acid autophosphorylation
GO:0048710  regulation of astrocyte differentiation
GO:0050770  regulation of axonogenesis
GO:0032314  regulation of Rac GTPase activity
GO:0032317  regulation of Rap GTPase activity

Cellular Component

GO:0030424  axon
GO:0030054  cell junction
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0030425  dendrite
GO:0043197  dendritic spine
GO:0031901  early endosome membrane
GO:0005783  endoplasmic reticulum
GO:0030175  filopodium
GO:0005794  Golgi apparatus
GO:0005887  integral to plasma membrane
GO:0005741  mitochondrial outer membrane
GO:0043679  nerve terminal
GO:0031594  neuromuscular junction
GO:0043204  perikaryon
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane

Molecular Function

GO:0005524  ATP binding
GO:0046875  ephrin receptor binding
GO:0005004  GPI-linked ephrin receptor activity
GO:0042731  PH domain binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0005005  transmembrane-ephrin receptor activity