EPH receptor A7

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Synonym

Tyrosine-protein kinase receptor EHK-3, EPH receptor A7, Receptor protein-tyrosine kinase HEK11, Ephrin type-A receptor 7 precursor, EphA7, EPH homology kinase 3, EPHA7, EHK3, Hek11, HEK11

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:47.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:2.78 cerebellum:2.94 brain stem:2.80 corpus callosum/glia:2.79 pineal gland:- peripheral nerve:2.53 spine:2.66 retina:- eye:- artery/aorta:2.76 vein:2.75 lymphnode:2.53 peripheral blood:- spleen:2.82 thymus:2.52 bone marrow:2.66 adipose:2.56 bone:- skin:2.64
CAGE cerebrum:3.84 cerebellum:- brain stem:2.86 corpus callosum/glia:1.88 pineal gland:4.38 peripheral nerve:- spine:3.59 retina:- eye:- artery/aorta:1.43 vein:0.96 lymphnode:0.86 peripheral blood:- spleen:3.39 thymus:0.50 bone marrow:- adipose:1.12 bone:- skin:-
RNA-seq cerebrum:1.64 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.21 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.05 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:4.30 heart:38.30 muscle:- esophagus:- stomach:- intestine:64.80 colon:-     liver/hepato:-        lung:-    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:2.82 placenta:2.68 prostate:3.13 ovary:2.69 testis:2.50 heart:2.77 muscle:2.66 esophagus:2.74 stomach:3.11 intestine:2.92 colon:2.81 liver/hepato:2.65 lung:2.51 bladder:- kidney:2.86 pituitary:2.65 thyroid/parathyroid:2.57 adrenal gland:2.56 pancreas:2.70 breast:2.62 salivary:2.99
CAGE uterus:2.49 placenta:0.77 prostate:4.69 ovary:1.75 testis:2.13 heart:2.54 muscle:0.82 esophagus:4.43 stomach:- intestine:3.69 colon:3.94     liver/hepato:0.26    lung:1.14 bladder:4.03 kidney:3.73 pituitary:3.33 thyroid/parathyroid:0.76 adrenal gland:- pancreas:0 breast:0.55 salivary:4.08
RNA-seq uterus:- placenta:- prostate:3.46 ovary:0.69 testis:1.27 heart:1.54 muscle:0.15 esophagus:- stomach:- intestine:- colon:4.45     liver/hepato:0        lung:0.30    bladder:- kidney:2.10 pituitary:- thyroid/parathyroid:0.30 adrenal gland:0.15 pancreas:- breast:0.14 salivary:-

Gene Information

IDs

Refseq ID NM_004440
Gene ID 2045
Unigene ID Hs.73962
Probe set ID 206852_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135333
GTEx ID ENSG00000135333

Orthologous Gene

Mouse[4]  NM_001122889, NM_010141
Rat [0]  

Chromosomal Region

6q16.1  [93,949,738  -  94,129,265]

Gene Family (Interpro ID)

IPR001090  Ephrin receptor, ligand binding
IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR008979  Galactose-binding domain-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001660  Sterile alpha motif
IPR010993  Sterile alpha motif homology
IPR013761  Sterile alpha motif-type
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR016257  Tyrosine-protein kinase, ephrin receptor
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7898931
8755474
8889548
9010230
9267020
9530499
9576626
9707552
9892426
10207129
10366629
10730216
11029633
11128993
11152476
11256076
12477932
14574404
14718574
15489334
16007213
16344560
17236141
17669470
17726105
18366728
18821581
19949912
20126984
20302756
20379614
21124932
21546767
21609571
21890473
21935409
21964981
21987572
21988832
22036564
22095909
22246354

Gene Ontology  (GO ID)

Biological Process

GO:0007420  brain development
GO:0048755  branching morphogenesis of a nerve
GO:0048013  ephrin receptor signaling pathway
GO:0050919  negative chemotaxis
GO:0016310  phosphorylation
GO:0043525  positive regulation of neuron apoptosis
GO:0043281  regulation of caspase activity
GO:0022407  regulation of cell-cell adhesion
GO:0070372  regulation of ERK1 and ERK2 cascade
GO:0050730  regulation of peptidyl-tyrosine phosphorylation
GO:0031952  regulation of protein amino acid autophosphorylation
GO:0031290  retinal ganglion cell axon guidance

Cellular Component

GO:0043025  cell soma
GO:0030425  dendrite
GO:0005887  integral to plasma membrane
GO:0031594  neuromuscular junction
GO:0045211  postsynaptic membrane

Molecular Function

GO:0005524  ATP binding
GO:0008046  axon guidance receptor activity
GO:0045499  chemorepellent activity
GO:0046875  ephrin receptor binding
GO:0005004  GPI-linked ephrin receptor activity
GO:0005515  protein binding
GO:0004713  protein tyrosine kinase activity