v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Synonym

c-erbB-3, c-erbB3, p85-sErbB3, p45-sErbB3, ERBB3, ErbB-3, MGC88033, Tyrosine kinase-type cell surface receptor HER3, Receptor tyrosine-protein kinase erbB-3 precursor, p180-ErbB3, HER3, MDA-BF-1, erbB3-S

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:150.50

cerebellum:37.80

brain stem:-

corpus callosum/glia:145.80

pineal gland:-

peripheral nerve:460.10

spine:336.90

retina:-

eye:35.30

artery/aorta:30

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:48

GeneChip

cerebrum:7.04

cerebellum:5.05

brain stem:7.51

corpus callosum/glia:8.54

pineal gland:-

peripheral nerve:8.65

spine:7.55

retina:-

eye:-

artery/aorta:5.30

vein:4.82

lymphnode:4.83

peripheral blood:-

spleen:3.91

thymus:3.60

bone marrow:4.14

adipose:4.63

bone:-

skin:6.98

CAGE

cerebrum:3.13

cerebellum:-

brain stem:3.87

corpus callosum/glia:4.61

pineal gland:2.03

peripheral nerve:-

spine:3.37

retina:-

eye:-

artery/aorta:2.34

vein:1.76

lymphnode:1.54

peripheral blood:-

spleen:0

thymus:0.42

bone marrow:-

adipose:0.55

bone:-

skin:-

RNA-seq

cerebrum:3.72

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.25

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.97

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:45.60

placenta:72.90

prostate:157.70

ovary:37.30

testis:4.30

heart:102.20

muscle:20.10

esophagus:342.80

stomach:42.50

intestine:64.80

colon:195

liver/hepato:10.60

lung:215.10

bladder:-

kidney:114.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:35.60

breast:176.60

salivary:-

GeneChip

uterus:5.46

placenta:7.46

prostate:7.76

ovary:5.33

testis:4.05

heart:4.75

muscle:4

esophagus:7.74

stomach:7.53

intestine:7.06

colon:8.10

liver/hepato:8.32

lung:6.13

bladder:-

kidney:7.66

pituitary:3.93

thyroid/parathyroid:5.54

adrenal gland:4.20

pancreas:6.95

breast:7.78

salivary:8.56

CAGE

uterus:2.31

placenta:3.58

prostate:3.27

ovary:1.41

testis:1.22

heart:1.65

muscle:0.86

esophagus:3.64

stomach:-

intestine:4.59

colon:4.50

liver/hepato:3.83

lung:3.37

bladder:2.51

kidney:3.23

pituitary:0.66

thyroid/parathyroid:2.50

adrenal gland:-

pancreas:3.84

breast:2.74

salivary:4.64

RNA-seq

uterus:-

placenta:-

prostate:3.66

ovary:1.48

testis:1.68

heart:0.57

muscle:0.57

esophagus:-

stomach:-

intestine:-

colon:3.91

liver/hepato:3.75

lung:3.27

bladder:-

kidney:3.33

pituitary:-

thyroid/parathyroid:2.31

adrenal gland:0.20

pancreas:-

breast:2.73

salivary:-

IDs

Refseq ID	NM_001982
Gene ID	2065
Unigene ID	Hs.118681
Probe set ID	202454_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000065361
GTEx ID	ENSG00000065361

Orthologous Gene

Mouse[2]	NM_010153
Rat [0]

Chromosomal Region

12q13.2 [56,473,641 - 56,497,289]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0021545	cranial nerve development
GO:0003197	endocardial cushion development
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0007507	heart development
GO:0045087	innate immune response
GO:0007162	negative regulation of cell adhesion
GO:0043524	negative regulation of neuron apoptosis
GO:0051048	negative regulation of secretion
GO:0009968	negative regulation of signal transduction
GO:0048011	nerve growth factor receptor signaling pathway
GO:0051402	neuron apoptosis
GO:0007422	peripheral nervous system development
GO:0014065	phosphoinositide 3-kinase cascade
GO:0048015	phosphoinositide-mediated signaling
GO:0014068	positive regulation of phosphoinositide 3-kinase cascade
GO:0042127	regulation of cell proliferation
GO:0014037	Schwann cell differentiation
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060	wound healing

Cellular Component

GO:0016324	apical plasma membrane
GO:0016323	basolateral plasma membrane
GO:0005615	extracellular space
GO:0005887	integral to plasma membrane
GO:0016328	lateral plasma membrane
GO:0005886	plasma membrane
GO:0043235	receptor complex

Molecular Function

GO:0005524	ATP binding
GO:0019838	growth factor binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0042803	protein homodimerization activity
GO:0030296	protein tyrosine kinase activator activity
GO:0004713	protein tyrosine kinase activity
GO:0004888	transmembrane receptor activity

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function