epiregulin

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Synonym

ER, EREG, epiregulin, Epiregulin precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:10.10 peripheral blood:54.70 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:52.80
GeneChip cerebrum:2.57 cerebellum:2.44 brain stem:2.64 corpus callosum/glia:2.52 pineal gland:- peripheral nerve:2.44 spine:2.51 retina:- eye:- artery/aorta:2.60 vein:2.54 lymphnode:2.54 peripheral blood:- spleen:2.50 thymus:2.46 bone marrow:3.39 adipose:2.65 bone:- skin:5.02
CAGE cerebrum:0.05 cerebellum:- brain stem:0.12 corpus callosum/glia:0.13 pineal gland:0 peripheral nerve:- spine:0.09 retina:- eye:- artery/aorta:1.28 vein:0.47 lymphnode:1.35 peripheral blood:- spleen:1.02 thymus:0.12 bone marrow:- adipose:0.55 bone:- skin:-
RNA-seq cerebrum:0.01 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.36 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.30 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:67.80     liver/hepato:-        lung:14.70    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:2.57 placenta:2.65 prostate:2.47 ovary:2.83 testis:2.36 heart:2.96 muscle:2.57 esophagus:4.68 stomach:2.53 intestine:2.52 colon:2.60 liver/hepato:2.49 lung:2.86 bladder:- kidney:2.39 pituitary:2.44 thyroid/parathyroid:2.40 adrenal gland:2.41 pancreas:2.60 breast:3.14 salivary:2.41
CAGE uterus:0.97 placenta:1.02 prostate:0.15 ovary:0.37 testis:0.19 heart:0.58 muscle:0.21 esophagus:2.73 stomach:- intestine:0.57 colon:0.76     liver/hepato:0.14    lung:2.02 bladder:1.56 kidney:0.33 pituitary:0.24 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0.55 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0.09 ovary:0.12 testis:0.07 heart:0.31 muscle:0 esophagus:- stomach:- intestine:- colon:0.61     liver/hepato:0.07        lung:1.44    bladder:- kidney:0.01 pituitary:- thyroid/parathyroid:0.02 adrenal gland:0.17 pancreas:- breast:0.12 salivary:-

Gene Information

IDs

Refseq ID NM_001432
Gene ID 2069
Unigene ID Hs.115263
Probe set ID 205767_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000124882
GTEx ID ENSG00000124882

Orthologous Gene

Mouse[1]  NM_007950
Rat [0]  

Chromosomal Region

4q13.3  [75,230,860  -  75,254,468]

Gene Family (Interpro ID)

IPR000742  EGF-like, type 3

Link to Pubmed  (Pubmed ID)

9337852
9419975
9553109
9990076
10681561
12477932
12702554
12898511
14572630
14581411
15274392
15474502
16888076
17429393
17962208
18079685
18292222
18497965
18821565
18835871
18948081
19138957
21161326
21769422
22170233
22508389
22747683
22916037
22964644
23074094
23383108
23625463
23671122
23826119
23829318
23885463
24092824
24330607
24335920
24800946

Gene Ontology  (GO ID)

Biological Process

GO:0009653  anatomical structure morphogenesis
GO:0001525  angiogenesis
GO:0007267  cell-cell signaling
GO:0019221  cytokine-mediated signaling pathway
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0007143  female meiosis
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0045087  innate immune response
GO:0030216  keratinocyte differentiation
GO:0043616  keratinocyte proliferation
GO:0042700  luteinizing hormone signaling pathway
GO:0009299  mRNA transcription
GO:0008285  negative regulation of cell proliferation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0051151  negative regulation of smooth muscle cell differentiation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0048011  nerve growth factor receptor signaling pathway
GO:0001556  oocyte maturation
GO:0009887  organ morphogenesis
GO:0001550  ovarian cumulus expansion
GO:0030728  ovulation
GO:0048015  phosphoinositide-mediated signaling
GO:0051781  positive regulation of cell division
GO:0008284  positive regulation of cell proliferation
GO:0042108  positive regulation of cytokine biosynthetic process
GO:0001819  positive regulation of cytokine production
GO:0045740  positive regulation of DNA replication
GO:0045741  positive regulation of epidermal growth factor receptor activity
GO:0048146  positive regulation of fibroblast proliferation
GO:0045089  positive regulation of innate immune response
GO:0045410  positive regulation of interleukin-6 biosynthetic process
GO:0045840  positive regulation of mitosis
GO:0042327  positive regulation of phosphorylation
GO:0045860  positive regulation of protein kinase activity
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0048160  primary follicle stage, oogenesis
GO:0043434  response to peptide hormone stimulus
GO:0042060  wound healing

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005887  integral to plasma membrane

Molecular Function

GO:0005154  epidermal growth factor receptor binding
GO:0008083  growth factor activity
GO:0005515  protein binding