excision repair cross-complementing rodent repair deficiency, complementation group 4

Synonym

ERCC4, DNA-repair protein complementing XP-F cells, DNA excision repair protein ERCC-4, DNA repair endonuclease XPF, ERCC11, XPF

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:8.30

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:118.60

eye:17.60

artery/aorta:-

vein:-

lymphnode:40.40

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:9.60

GeneChip

cerebrum:6.11

cerebellum:5.98

brain stem:6.08

corpus callosum/glia:6.27

pineal gland:-

peripheral nerve:6.09

spine:6.38

retina:-

eye:-

artery/aorta:5.89

vein:6.11

lymphnode:5.96

peripheral blood:-

spleen:5.89

thymus:5.77

bone marrow:6.26

adipose:5.95

bone:-

skin:5.81

CAGE

cerebrum:2.83

cerebellum:-

brain stem:2.96

corpus callosum/glia:2.90

pineal gland:3.10

peripheral nerve:-

spine:3.05

retina:-

eye:-

artery/aorta:2.46

vein:2.52

lymphnode:2.44

peripheral blood:-

spleen:2.55

thymus:3.03

bone marrow:-

adipose:2.77

bone:-

skin:-

RNA-seq

cerebrum:1.78

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.80

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.14

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:14.60

prostate:11.30

ovary:-

testis:73.50

heart:-

muscle:20.10

esophagus:-

stomach:-

intestine:-

colon:17

liver/hepato:10.60

lung:-

bladder:-

kidney:20.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:-

breast:65.10

salivary:-

GeneChip

uterus:5.85

placenta:6.41

prostate:5.66

ovary:6.04

testis:6.73

heart:6.26

muscle:6.07

esophagus:5.84

stomach:6.05

intestine:6.06

colon:6.06

liver/hepato:6.02

lung:5.85

bladder:-

kidney:5.97

pituitary:6.34

thyroid/parathyroid:5.96

adrenal gland:6.14

pancreas:6.51

breast:6.01

salivary:6.07

CAGE

uterus:2.78

placenta:2.41

prostate:2.60

ovary:2.79

testis:3.06

heart:2.54

muscle:2.70

esophagus:2.36

stomach:-

intestine:2.10

colon:2.34

liver/hepato:2.37

lung:2.44

bladder:2.66

kidney:2.46

pituitary:3.13

thyroid/parathyroid:2.46

adrenal gland:-

pancreas:2.34

breast:2.19

salivary:2.46

RNA-seq

uterus:-

placenta:-

prostate:1.71

ovary:2.38

testis:2.15

heart:1.59

muscle:1.78

esophagus:-

stomach:-

intestine:-

colon:1.19

liver/hepato:1.07

lung:0.64

bladder:-

kidney:1.53

pituitary:-

thyroid/parathyroid:1.55

adrenal gland:1.54

pancreas:-

breast:1.51

salivary:-

IDs

Refseq ID	NM_005236
Gene ID	2072
Unigene ID	Hs.567265
Probe set ID	210158_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000175595
GTEx ID	ENSG00000175595

Orthologous Gene

Mouse[2]	NM_015769
Rat[2]	NM_015769

Chromosomal Region

16p13.12 [14,014,014 - 14,046,205]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR006166	ERCC4 domain
IPR011335	Restriction endonuclease, type II-like, core

Gene Ontology (GO ID)

Biological Process

GO:0006281	DNA repair
GO:0000724	double-strand break repair via homologous recombination
GO:0000710	meiotic mismatch repair
GO:0032205	negative regulation of telomere maintenance
GO:0006289	nucleotide-excision repair
GO:0000718	nucleotide-excision repair, DNA damage removal
GO:0033683	nucleotide-excision repair, DNA incision
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0000712	resolution of meiotic recombination intermediates
GO:0009411	response to UV
GO:0000723	telomere maintenance
GO:0010834	telomere maintenance via telomere shortening
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0009650	UV protection

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000784	nuclear chromosome, telomeric region
GO:0005654	nucleoplasm
GO:0000109	nucleotide-excision repair complex
GO:0000110	nucleotide-excision repair factor 1 complex
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex

Molecular Function

GO:0003684	damaged DNA binding
GO:0004520	endodeoxyribonuclease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0047485	protein N-terminus binding
GO:0003697	single-stranded DNA binding
GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity
GO:0043566	structure-specific DNA binding

excision repair cross-complementing rodent repair deficiency, complementation group 4

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function