excision repair cross-complementing rodent repair deficiency, complementation group 6

Synonym

COFS, RAD26, ERCC6, Cockayne syndrome protein CSB, DNA excision repair protein ERCC-6, CSB, ATP-dependent helicase ERCC6, CKN2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:4.51

cerebellum:4.46

brain stem:4.48

corpus callosum/glia:4.59

pineal gland:-

peripheral nerve:4.54

spine:4.62

retina:-

eye:-

artery/aorta:4.92

vein:4.57

lymphnode:4.69

peripheral blood:-

spleen:4.58

thymus:4.77

bone marrow:4.62

adipose:4.47

bone:-

skin:4.50

CAGE

nodata

RNA-seq

cerebrum:1.02

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.16

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.93

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:4.62

placenta:4.28

prostate:4.67

ovary:4.66

testis:5.49

heart:4.54

muscle:4.56

esophagus:4.55

stomach:4.58

intestine:4.54

colon:4.43

liver/hepato:4.66

lung:4.41

bladder:-

kidney:4.46

pituitary:4.83

thyroid/parathyroid:4.76

adrenal gland:4.58

pancreas:4.53

breast:4.67

salivary:4.70

CAGE

nodata

RNA-seq

uterus:-

placenta:-

prostate:1.58

ovary:1.12

testis:1.83

heart:1.27

muscle:1.45

esophagus:-

stomach:-

intestine:-

colon:1.20

liver/hepato:0.66

lung:0.79

bladder:-

kidney:1.35

pituitary:-

thyroid/parathyroid:1.60

adrenal gland:1.00

pancreas:-

breast:1.03

salivary:-

IDs

Refseq ID	NM_000124
Gene ID	2074
Unigene ID	-
Probe set ID	207347_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000225830
GTEx ID	ENSG00000225830

Orthologous Gene

Mouse[1]	NM_001081221
Rat[1]	NM_001107296

Chromosomal Region

10q11.23 [50,663,414 - 50,747,584]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR014001	DEAD-like helicase, N-terminal
IPR014021	Helicase, superfamily 1/2, ATP-binding domain

Gene Ontology (GO ID)

Biological Process

GO:0007256	activation of JNKK activity
GO:0007257	activation of JUN kinase activity
GO:0006284	base-excision repair
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis
GO:0006281	DNA repair
GO:0035264	multicellular organism growth
GO:0006289	nucleotide-excision repair
GO:0045494	photoreceptor cell maintenance
GO:0032786	positive regulation of RNA elongation
GO:0006290	pyrimidine dimer repair
GO:0032784	regulation of RNA elongation
GO:0010332	response to gamma radiation
GO:0006979	response to oxidative stress
GO:0000303	response to superoxide
GO:0009636	response to toxin
GO:0009411	response to UV
GO:0010224	response to UV-B
GO:0010165	response to X-ray
GO:0006366	transcription from RNA polymerase II promoter
GO:0006283	transcription-coupled nucleotide-excision repair

Cellular Component

GO:0005730	nucleolus
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0008023	transcription elongation factor complex

Molecular Function

GO:0005524	ATP binding
GO:0003682	chromatin binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0008094	DNA-dependent ATPase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0032403	protein complex binding
GO:0047485	protein N-terminus binding

excision repair cross-complementing rodent repair deficiency, complementation group 6

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function