fibroblast growth factor 4

 jump to detail

Synonym

HBGF-4, FGF4, Fibroblast growth factor 4 precursor, HST, HST-1, Heparin secretory-transforming protein, KFGF, KS3, K-FGF, Transforming protein KS3, FGF-4, HSTF1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:47.40 cerebellum:88.20 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:118.60 eye:52.90 artery/aorta:30 vein:66.60 lymphnode:91 peripheral blood:18.20 spleen:- thymus:- bone marrow:19.70 adipose:- bone:- skin:28.80
GeneChip nodata
CAGE cerebrum:0 cerebellum:- brain stem:0.19 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0.09 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:58.30 prostate:11.30 ovary:37.30 testis:21.60 heart:38.30 muscle:- esophagus:- stomach:- intestine:32.40 colon:50.90     liver/hepato:10.60        lung:19.60    bladder:- kidney:145.60 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:80 breast:120.80 salivary:-
GeneChip nodata
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0.04 heart:0 muscle:0 esophagus:0 stomach:- intestine:0.14 colon:0.08     liver/hepato:0    lung:0 bladder:0 kidney:0.08 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0.20 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_002007
Gene ID 2249
Unigene ID Hs.175534
Probe set ID -
Ensembl ID ENSG00000075388
GTEx ID ENSG00000075388

Orthologous Gene

Mouse[3]  NM_010202
Rat[3]  NM_010202

Chromosomal Region

11q13.3  [69,587,797  -  69,590,171]

Gene Family (Interpro ID)

IPR008996  Cytokine, IL-1-like
IPR002209  Heparin-binding growth factor/Fibroblast growth factor
IPR002348  Interleukin 1/heparin-binding growth factor

Link to Pubmed  (Pubmed ID)

1611909
1697263
2953031
2957062
2959959
2974287
3060803
3283658
8663044
9139660
10089404
10579907
11021964
11023873
11294897
11486033
11743396
11840335
12008951
12163055
12172783
12660731
12841847
12923055
14980503
15146197
15199049
15695515
16597617
17133345
17167778
17390055
17852409
18192227
18510611
18811955
19074885
19277121
20452482
20453838
20634891
20673868
20864512
21048031
21567388
21673370
22237711
22587598
24120895

Gene Ontology  (GO ID)

Biological Process

GO:0060561  apoptosis involved in morphogenesis
GO:0001502  cartilage condensation
GO:0007267  cell-cell signaling
GO:0060591  chondroblast differentiation
GO:0060363  cranial suture morphogenesis
GO:0035116  embryonic hindlimb morphogenesis
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0010463  mesenchymal cell proliferation
GO:0043066  negative regulation of apoptosis
GO:0048011  nerve growth factor receptor signaling pathway
GO:0042475  odontogenesis of dentine-containing tooth
GO:0048015  phosphoinositide-mediated signaling
GO:0051781  positive regulation of cell division
GO:0008284  positive regulation of cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0007165  signal transduction
GO:0019827  stem cell maintenance

Cellular Component

GO:0005829  cytosol
GO:0005576  extracellular region
GO:0005634  nucleus

Molecular Function

GO:0005104  fibroblast growth factor receptor binding
GO:0008083  growth factor activity
GO:0008201  heparin binding