fibroblast growth factor 10

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Synonym

Fibroblast growth factor 10 precursor, FGF10, FGF-10, Keratinocyte growth factor 2, fibroblast growth factor 10

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip nodata
CAGE cerebrum:0.13 cerebellum:- brain stem:0.29 corpus callosum/glia:0.18 pineal gland:0 peripheral nerve:- spine:0.78 retina:- eye:- artery/aorta:0.87 vein:1.17 lymphnode:0.49 peripheral blood:- spleen:0 thymus:0.06 bone marrow:- adipose:1.57 bone:- skin:-
RNA-seq cerebrum:0.14 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.12 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.24 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip nodata
CAGE uterus:1.55 placenta:0.95 prostate:2.03 ovary:1.46 testis:1.25 heart:0.78 muscle:0.13 esophagus:1.08 stomach:- intestine:0.57 colon:1.12     liver/hepato:0    lung:0.58 bladder:1.64 kidney:0.15 pituitary:1.24 thyroid/parathyroid:1.02 adrenal gland:- pancreas:1.42 breast:0.55 salivary:0.83
RNA-seq uterus:- placenta:- prostate:2.84 ovary:2.39 testis:2.34 heart:0.61 muscle:0.28 esophagus:- stomach:- intestine:- colon:3.16     liver/hepato:0        lung:2.23    bladder:- kidney:0.78 pituitary:- thyroid/parathyroid:2.10 adrenal gland:1.47 pancreas:- breast:2.29 salivary:-

Gene Information

IDs

Refseq ID NM_004465
Gene ID 2255
Unigene ID -
Probe set ID -
Ensembl ID ENSG00000070193
GTEx ID ENSG00000070193

Orthologous Gene

Mouse[1]  NM_008002
Rat [0]  

Chromosomal Region

5p12  [44,303,646  -  44,389,808]

Gene Family (Interpro ID)

IPR008996  Cytokine, IL-1-like
IPR002209  Heparin-binding growth factor/Fibroblast growth factor
IPR002348  Interleukin 1/heparin-binding growth factor

Link to Pubmed  (Pubmed ID)

8622701
9287324
9582367
9740653
9916808
9927546
10541313
10579907
10629055
10951499
11286634
11294897
11896977
11923311
12477932
12591959
12804770
12818887
14726452
14975937
15199049
15208658
15489334
15632068
15654336
15679583
15690149
15806171
16086254
16323074
16501574
16597614
16597617
16630169
17071719
17133345
17188682
17213838
17264867
17360555
17449030
17471512
17496316
17500053
17609292
17682060
17944804
17959718
17969154
18081024
18329286
18437684
18454440
18587586
18594526
18773495
18990706
19102732
19115389
19152659
19224135
19727229
19915940
20036575
20083228
20424473
20544801
20634891
20705941
21048031
21310815
21696361
21742743
21743467
22303449
22877940
22965740
23169889
23328208
23599340
23774963
23949743
24002438
24004862
24265547

Gene Ontology  (GO ID)

Biological Process

GO:0031532  actin cytoskeleton reorganization
GO:0000187  activation of MAPK activity
GO:0001525  angiogenesis
GO:0001974  blood vessel remodeling
GO:0060667  branch elongation involved in salivary gland morphogenesis
GO:0048754  branching morphogenesis of a tube
GO:0060436  bronchiole morphogenesis
GO:0060447  bud outgrowth involved in lung branching
GO:0007368  determination of left/right symmetry
GO:0031076  embryonic camera-type eye development
GO:0048557  embryonic digestive tract morphogenesis
GO:0030538  embryonic genitalia morphogenesis
GO:0009880  embryonic pattern specification
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0010631  epithelial cell migration
GO:0050673  epithelial cell proliferation
GO:0060664  epithelial cell proliferation involved in salivary gland morphogenesis
GO:0070371  ERK1 and ERK2 cascade
GO:0048807  female genitalia morphogenesis
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0060595  fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069  hair follicle morphogenesis
GO:0070384  Harderian gland development
GO:0001759  induction of an organ
GO:0050930  induction of positive chemotaxis
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0043616  keratinocyte proliferation
GO:0032808  lacrimal gland development
GO:0060174  limb bud formation
GO:0060428  lung epithelium development
GO:0060430  lung saccule development
GO:0048808  male genitalia morphogenesis
GO:0060615  mammary gland bud formation
GO:0060915  mesenchymal cell differentiation involved in lung development
GO:0060496  mesenchymal-endodermal cell signaling involved in lung development
GO:0001823  mesonephros development
GO:0001656  metanephros development
GO:0003338  metanephros morphogenesis
GO:0042693  muscle cell fate commitment
GO:0043066  negative regulation of apoptosis
GO:0071157  negative regulation of cell cycle arrest
GO:0008285  negative regulation of cell proliferation
GO:0048011  nerve growth factor receptor signaling pathway
GO:0042475  odontogenesis of dentine-containing tooth
GO:0030916  otic vesicle formation
GO:0031016  pancreas development
GO:0048015  phosphoinositide-mediated signaling
GO:0021983  pituitary gland development
GO:0050918  positive chemotaxis
GO:0032781  positive regulation of ATPase activity
GO:0031659  positive regulation of cyclin-dependent protein kinase activity during G1/S
GO:0045739  positive regulation of DNA repair
GO:0045740  positive regulation of DNA replication
GO:0010634  positive regulation of epithelial cell migration
GO:0050679  positive regulation of epithelial cell proliferation
GO:0060054  positive regulation of epithelial cell proliferation involved in wound healing
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0048146  positive regulation of fibroblast proliferation
GO:0071338  positive regulation of hair follicle cell proliferation
GO:0051549  positive regulation of keratinocyte migration
GO:0010838  positive regulation of keratinocyte proliferation
GO:0050671  positive regulation of lymphocyte proliferation
GO:0043410  positive regulation of MAPKKK cascade
GO:0045931  positive regulation of mitotic cell cycle
GO:0045747  positive regulation of Notch signaling pathway
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0046579  positive regulation of Ras protein signal transduction
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0050677  positive regulation of urothelial cell proliferation
GO:0030949  positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0070352  positive regulation of white fat cell proliferation
GO:0034394  protein localization at cell surface
GO:0060019  radial glial cell differentiation
GO:0032925  regulation of activin receptor signaling pathway
GO:0060665  regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060685  regulation of prostatic bud formation
GO:0046877  regulation of saliva secretion
GO:0008589  regulation of smoothened signaling pathway
GO:0032355  response to estradiol stimulus
GO:0032496  response to lipopolysaccharide
GO:0007431  salivary gland development
GO:0060879  semicircular canal fusion
GO:0051145  smooth muscle cell differentiation
GO:0035019  somatic stem cell maintenance
GO:0048536  spleen development
GO:0060661  submandibular salivary gland formation
GO:0070075  tear secretion
GO:0048538  thymus development
GO:0030878  thyroid gland development
GO:0042246  tissue regeneration
GO:0060510  Type II pneumocyte differentiation
GO:0050674  urothelial cell proliferation
GO:0050872  white fat cell differentiation
GO:0042060  wound healing

Cellular Component

GO:0009986  cell surface
GO:0031012  extracellular matrix
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0042056  chemoattractant activity
GO:0005104  fibroblast growth factor receptor binding
GO:0008083  growth factor activity
GO:0008201  heparin binding
GO:0005111  type 2 fibroblast growth factor receptor binding