mitogen-activated protein kinase 15

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Synonym

mitogen-activated protein kinase 15, ERK8, Mitogen-activated protein kinase 15, Extracellular signal-regulated kinase 8, ERK7, MAPK15

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:17.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:25.80 bone marrow:- adipose:- bone:- skin:4.80
GeneChip nodata
CAGE cerebrum:0.66 cerebellum:- brain stem:0.26 corpus callosum/glia:2.11 pineal gland:0.51 peripheral nerve:- spine:0.09 retina:- eye:- artery/aorta:1.65 vein:0.34 lymphnode:0.12 peripheral blood:- spleen:0 thymus:0.06 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.21 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.09 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:8.70 heart:- muscle:- esophagus:- stomach:- intestine:- colon:50.90     liver/hepato:-        lung:9.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:65.10 salivary:-
GeneChip nodata
CAGE uterus:0.64 placenta:0.37 prostate:0.39 ovary:1.59 testis:1.74 heart:0.22 muscle:0 esophagus:0.57 stomach:- intestine:0.07 colon:0.12     liver/hepato:0.14    lung:2.06 bladder:0.18 kidney:0.71 pituitary:1.47 thyroid/parathyroid:1.30 adrenal gland:- pancreas:0.58 breast:0.55 salivary:0
RNA-seq uterus:- placenta:- prostate:0.28 ovary:2.05 testis:1.08 heart:0.01 muscle:0 esophagus:- stomach:- intestine:- colon:0.04     liver/hepato:0.04        lung:2.17    bladder:- kidney:0.44 pituitary:- thyroid/parathyroid:1.77 adrenal gland:0.10 pancreas:- breast:0.32 salivary:-

Gene Information

IDs

Refseq ID NM_139021
Gene ID 225689
Unigene ID Hs.493169
Probe set ID -
Ensembl ID ENSG00000181085
GTEx ID ENSG00000181085

Orthologous Gene

Mouse[1]  NM_177922
Rat[1]  NM_173331

Chromosomal Region

8q24.3  [144,798,429  -  144,804,628]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9880541
11875070
12239168
12477932
15342556
15489334
16336213
16484222
16624805
18029348
19166846
20395206
20733054
21190936
22939624
22948227
23251661
23326322
23455922
23602568

Gene Ontology  (GO ID)

Biological Process

GO:0000165  MAPKKK cascade
GO:0008156  negative regulation of DNA replication
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045732  positive regulation of protein catabolic process
GO:0031398  positive regulation of protein ubiquitination
GO:0046777  protein amino acid autophosphorylation
GO:0032355  response to estradiol stimulus

Cellular Component

GO:0005576  extracellular region
GO:0005622  intracellular
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0004707  MAP kinase activity
GO:0017124  SH3 domain binding