fibroblast growth factor receptor 2

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Synonym

CD332, JWS, FGFR-2, ECT1, Keratinocyte growth factor receptor 2, TK25, CFD1, CEK3, TK14, BEK, CD332 antigen, KGFR, K-SAM, BFR-1, FGFR2, KSAM, Fibroblast growth factor receptor 2 precursor

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:68.70 cerebellum:100.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:490.80 spine:- retina:- eye:94 artery/aorta:30 vein:- lymphnode:- peripheral blood:- spleen:- thymus:25.80 bone marrow:19.70 adipose:- bone:64 skin:81.60
GeneChip cerebrum:8.69 cerebellum:8.33 brain stem:9 corpus callosum/glia:9.68 pineal gland:- peripheral nerve:5.59 spine:9.51 retina:- eye:- artery/aorta:5.88 vein:6.24 lymphnode:5.89 peripheral blood:- spleen:4.79 thymus:5.83 bone marrow:5.04 adipose:6.09 bone:- skin:7.82
CAGE cerebrum:3.89 cerebellum:- brain stem:4.63 corpus callosum/glia:5.13 pineal gland:1.12 peripheral nerve:- spine:4.84 retina:- eye:- artery/aorta:2.26 vein:1.17 lymphnode:1.00 peripheral blood:- spleen:0 thymus:1.29 bone marrow:- adipose:1.01 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:32.80 prostate:146.40 ovary:- testis:26 heart:38.30 muscle:- esophagus:- stomach:- intestine:- colon:17     liver/hepato:42.20        lung:83.10    bladder:- kidney:83.20 pituitary:116 thyroid/parathyroid:- adrenal gland:50.80 pancreas:35.60 breast:46.50 salivary:-
GeneChip uterus:8.08 placenta:6.67 prostate:8.05 ovary:7.77 testis:5.99 heart:5.38 muscle:5.20 esophagus:7.09 stomach:7.07 intestine:6.88 colon:7.53 liver/hepato:7.59 lung:6.47 bladder:- kidney:7.64 pituitary:6 thyroid/parathyroid:8.53 adrenal gland:7.28 pancreas:7.47 breast:7.79 salivary:8.81
CAGE uterus:3.24 placenta:2.14 prostate:2.77 ovary:2.57 testis:1.91 heart:0.92 muscle:0.13 esophagus:2.68 stomach:- intestine:2.12 colon:3.11     liver/hepato:2.37    lung:3.23 bladder:2.33 kidney:3.13 pituitary:1.64 thyroid/parathyroid:3.35 adrenal gland:- pancreas:3.02 breast:1.68 salivary:3.90
RNA-seq uterus:- placenta:- prostate:1.15 ovary:0.25 testis:0.21 heart:0.00 muscle:0 esophagus:- stomach:- intestine:- colon:0.01     liver/hepato:1.18        lung:0.45    bladder:- kidney:1.60 pituitary:- thyroid/parathyroid:4.08 adrenal gland:0.00 pancreas:- breast:1.23 salivary:-

IDs

Refseq ID NM_022970
Gene ID 2263
Unigene ID Hs.533683
Probe set ID 203638_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000066468
GTEx ID ENSG00000066468

Orthologous Gene

Mouse[3]  NM_010207, NM_201601
Rat[18]  NM_001109892, NM_001109893, NM_001109894, NM_001109895, NM_001109896, NM_012712

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1309608
1313574
1380281
1400433
1582255
1647213
1648704
1652059
1674718
1697263
1846048
2172978
2377625
7528517
7581378
7655462
7668257
7687739
7719333
7719344
7719345
7866434
7874170
7987400
7999363
8188211
8355693
8386828
8417497
8434615
8528214
8576175
8644708
8663044
8673103
8676562
8696350
8889548
8946174
8956050
8958319
9002682
9018118
9150725
9152842
9212826
9266968
9300181
9385368
9521581
9582367
9585583
9677057
9693549
9714439
9719378
10196476
10394936
10574673
10579907
10618369
10626794
10712195
10751172
10830168
10945669
10950949
10951518
11069186
11173845
11292657
11294897
11325814
11353842
11380921
11390973
11493535
11556600
11693202
11759058
11781872
11856867
11876253
11923311
11937263
12000365
12032146
12072807
12122441
12162872
12168799
12373339
12393912
12477932
12482414
12493773
12529371
12591959
12608893
12618336
12648559
12684685
12684693
12692135
12893942
14559809
14624010
14732692
15069536
15105428
15146197
15190072
15206560
15229180
15282208
15389579
15489334
15516981
15523492
15561780
15602758
15618886
15622262
15629145
15632068
15643506
15728256
15796961
15829502
15840724
15863034
15930103
15931389
16061565
16091423
16141466
16188231
16210019
16216128
16219767
16365308
16373332
16384934
16385451
16391783
16410617
16418739
16440883
16501574
16597614
16603716
16709412
16807244
16842598
16844695
16984257
17133345
17189145
17243131
17251833
17264867
17343269
17414280
17449949
17458890
17459342
17471512
17482184
17512901
17525264
17525745
17529967
17529973
17537644
17545628
17593825
17622301
17682060
17692400
17699848
17760502
17803937
17850625
17944804
17953372
17959718
17981115
17997823
18029348
18049087
18056630
18216705
18247426
18285324
18315732
18337450
18355772
18373495
18374639
18381441
18387281
18391499
18393251
18437204
18462018
18483326
18563556
18573884
18593464
18629881
18636142
18671283
18726952
18757403
18767044
18785201
18804962
18813210
18829480
18829569
18840094
18845558
18973230
19028704
19060208
19094228
19095219
19103595
19106113
19111446
19147536
19211868
19212647
19223389
19224135
19232126
19243295
19277121
19285943
19287982
19330030
19351817
19362549
19403560
19434818
19453261
19469636
19497954
19500394
19509166
19536173
19582883
19590514
19608737
19617217
19656774
19728793
19735729
19789366
19812598
19822079
19843670
19856316
19861516
19923290
19937600
19953087
20043066
20054709
20056625
20093481
20106510
20124286
20145138
20163525
20193855
20214895
20237344
20300826
20301368
20301533
20301592
20301628
20348248
20364400
20379614
20388777
20410112
20417875
20453838
20502973
20538960
20554749
20605201
20620021
20634891
20635358
20640597
20664043
20677155
20717167
20798558
20809772
20838624
20844240
20853316
20856019
20872241
20957671
20959865
21048031
21060860
21152424
21160077
21173787
21263130
21285871
21329481
21382839
21412257
21451043
21464042
21527526
21596750
21625213
21725289
21745712
21767389
21822685
21832049
21838531
21928350
21957444
21988832
21990352
21996728
22006548
22048896
22144180
22195012
22240789
22244757
22287734
22345151
22355256
22374580
22383975
22387015
22404656
22440254
22440694
22495904
22627435
22661218
22665975
22726438
22731611
22752927
22778155
22926736
22951594
22961180
22988296
23027129
23060048
23071632
23124475
23142580
23143756
23169889
23184080
23225170
23263486
23300780
23300950
23325524
23348274
23354978
23393200
23431754
23444225
23493349
23527311
23532954
23535729
23545898
23546041
23552627
23564461
23620752
23640291
23672191
23674849
23754559
23786770
23867503
23906837
23908597
24004862
24043118
24054997
24105470
24122810
24143190
24306956
24385678
24405590
24440983
24457912
24518603
24657306
24776567

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0007409  axonogenesis
GO:0060348  bone development
GO:0030282  bone mineralization
GO:0060349  bone morphogenesis
GO:0060667  branch elongation involved in salivary gland morphogenesis
GO:0060670  branching involved in embryonic placenta morphogenesis
GO:0060442  branching involved in prostate gland morphogenesis
GO:0060445  branching involved in salivary gland morphogenesis
GO:0048755  branching morphogenesis of a nerve
GO:0060449  bud elongation involved in lung branching
GO:0045165  cell fate commitment
GO:0007267  cell-cell signaling
GO:0060365  coronal suture morphogenesis
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0048557  embryonic digestive tract morphogenesis
GO:0048568  embryonic organ development
GO:0048562  embryonic organ morphogenesis
GO:0009880  embryonic pattern specification
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0048730  epidermis morphogenesis
GO:0030855  epithelial cell differentiation
GO:0060664  epithelial cell proliferation involved in salivary gland morphogenesis
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0060595  fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0022612  gland morphogenesis
GO:0048565  gut development
GO:0031069  hair follicle morphogenesis
GO:0001701  in utero embryonic development
GO:0045087  innate immune response
GO:0042472  inner ear morphogenesis
GO:0008286  insulin receptor signaling pathway
GO:0032808  lacrimal gland development
GO:0060601  lateral sprouting from an epithelium
GO:0070307  lens fiber cell development
GO:0060174  limb bud formation
GO:0048286  lung alveolus development
GO:0030324  lung development
GO:0060463  lung lobe morphogenesis
GO:0060484  lung-associated mesenchyme development
GO:0060615  mammary gland bud formation
GO:0003149  membranous septum morphogenesis
GO:0048762  mesenchymal cell differentiation
GO:0060915  mesenchymal cell differentiation involved in lung development
GO:0060916  mesenchymal cell proliferation involved in lung development
GO:0030901  midbrain development
GO:0016331  morphogenesis of embryonic epithelium
GO:0035264  multicellular organism growth
GO:0008285  negative regulation of cell proliferation
GO:0045839  negative regulation of mitosis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0048011  nerve growth factor receptor signaling pathway
GO:0021847  neuroblast division in the ventricular zone
GO:0007528  neuromuscular junction development
GO:0042476  odontogenesis
GO:0021769  orbitofrontal cortex development
GO:0035265  organ growth
GO:0009887  organ morphogenesis
GO:0030916  otic vesicle formation
GO:0003148  outflow tract septum morphogenesis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0048015  phosphoinositide-mediated signaling
GO:0060045  positive regulation of cardiac muscle cell proliferation
GO:0045787  positive regulation of cell cycle
GO:0051781  positive regulation of cell division
GO:0008284  positive regulation of cell proliferation
GO:0050679  positive regulation of epithelial cell proliferation
GO:0060501  positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0043410  positive regulation of MAPKKK cascade
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0010518  positive regulation of phospholipase activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0030177  positive regulation of Wnt receptor signaling pathway
GO:0009791  post-embryonic development
GO:0060527  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523  prostate epithelial cord elongation
GO:0060512  prostate gland morphogenesis
GO:0046777  protein amino acid autophosphorylation
GO:0021860  pyramidal neuron development
GO:0060687  regulation of branching involved in prostate gland morphogenesis
GO:0010453  regulation of cell fate commitment
GO:0070372  regulation of ERK1 and ERK2 cascade
GO:0040036  regulation of fibroblast growth factor receptor signaling pathway
GO:0060688  regulation of morphogenesis of a branching structure
GO:0040014  regulation of multicellular organism growth
GO:0045667  regulation of osteoblast differentiation
GO:0033688  regulation of osteoblast proliferation
GO:0051150  regulation of smooth muscle cell differentiation
GO:0008589  regulation of smoothened signaling pathway
GO:0048608  reproductive structure development
GO:0048705  skeletal system morphogenesis
GO:0060529  squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489  synaptic vesicle transport
GO:0001657  ureteric bud development
GO:0055010  ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0005938  cell cortex
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0060076  excitatory synapse
GO:0031012  extracellular matrix
GO:0005576  extracellular region
GO:0005794  Golgi apparatus
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0017134  fibroblast growth factor binding
GO:0005007  fibroblast growth factor receptor activity
GO:0008201  heparin binding
GO:0042802  identical protein binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004713  protein tyrosine kinase activity