Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

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Synonym

P55-FGR, p58c-fgr, FGR, MGC75096, c-src2, p55c-fgr, SRC2, C-FGR, c-fgr, FLJ43153, Proto-oncogene tyrosine-protein kinase FGR

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:19 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:118.60 eye:5.90 artery/aorta:60 vein:- lymphnode:70.80 peripheral blood:18.20 spleen:37.80 thymus:90.20 bone marrow:59 adipose:40.30 bone:25.60 skin:9.60
GeneChip cerebrum:5.47 cerebellum:5.28 brain stem:5.53 corpus callosum/glia:5.25 pineal gland:- peripheral nerve:5.49 spine:5.56 retina:- eye:- artery/aorta:5.87 vein:5.60 lymphnode:6.69 peripheral blood:- spleen:8.09 thymus:5.90 bone marrow:9.10 adipose:5.95 bone:- skin:6.04
CAGE cerebrum:1.56 cerebellum:- brain stem:2.18 corpus callosum/glia:1.44 pineal gland:1.46 peripheral nerve:- spine:2.28 retina:- eye:- artery/aorta:2.30 vein:3.02 lymphnode:3.34 peripheral blood:- spleen:3.82 thymus:1.46 bone marrow:- adipose:3.62 bone:- skin:-
RNA-seq cerebrum:0.48 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.64 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.98 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:7.30 prostate:11.30 ovary:- testis:17.30 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:-     liver/hepato:42.20        lung:29.30    bladder:- kidney:93.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:37.20 salivary:-
GeneChip uterus:5.53 placenta:5.60 prostate:5.43 ovary:5.34 testis:5.26 heart:5.56 muscle:5.37 esophagus:5.48 stomach:5.84 intestine:5.46 colon:5.76 liver/hepato:6.05 lung:7.94 bladder:- kidney:5.37 pituitary:5.50 thyroid/parathyroid:5.65 adrenal gland:5.49 pancreas:5.68 breast:5.72 salivary:5.47
CAGE uterus:2.14 placenta:1.86 prostate:1.51 ovary:1.58 testis:1.23 heart:2.58 muscle:1.79 esophagus:1.54 stomach:- intestine:1.44 colon:1.86     liver/hepato:1.66    lung:4.00 bladder:1.92 kidney:1.80 pituitary:0.87 thyroid/parathyroid:1.15 adrenal gland:- pancreas:1.21 breast:2.47 salivary:1.58
RNA-seq uterus:- placenta:- prostate:1.05 ovary:1.15 testis:0.77 heart:0.75 muscle:0.00 esophagus:- stomach:- intestine:- colon:1.34     liver/hepato:1.07        lung:2.80    bladder:- kidney:1.44 pituitary:- thyroid/parathyroid:0.82 adrenal gland:2.59 pancreas:- breast:0.91 salivary:-

Gene Information

IDs

Refseq ID NM_001042729
Gene ID 2268
Unigene ID Hs.14222
Probe set ID 208438_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000000938
GTEx ID ENSG00000000938

Orthologous Gene

Mouse[1]  NM_010208
Rat [0]  

Chromosomal Region

1p36.11  [27,938,575  -  27,961,788]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1339476
1373875
1652975
1690869
1826268
1847500
2154410
2181286
2581127
2852026
2995972
3003578
3023853
3275868
3330776
3922831
7515063
7519620
7565724
7678701
7721825
7726865
7812001
8313462
8327512
8603737
8612628
8753773
8805332
8824280
8867673
9208935
10066823
10080533
10229804
10358777
10527858
10702640
10739672
10973280
11071635
11162638
11526478
11546677
11672534
11744621
11823534
11928806
12096713
12244095
12387730
12387813
12435267
12468645
12473651
12477932
12482968
14702039
15094368
15098032
15190072
15459198
15489334
15536084
15561106
15707590
15723811
15919723
16273093
16344560
16710414
17164290
17845055
20056178
20098747
21300758
21890473
21963094
21988832
22745667
22939624
22974441
23000965
23867815
23896410

Gene Ontology  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0050830  defense response to Gram-positive bacterium
GO:0002768  immune response-regulating cell surface receptor signaling pathway
GO:0045087  innate immune response
GO:0007229  integrin-mediated signaling pathway
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0030335  positive regulation of cell migration
GO:0050715  positive regulation of cytokine secretion
GO:0043306  positive regulation of mast cell degranulation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0008360  regulation of cell shape
GO:0045088  regulation of innate immune response
GO:0050764  regulation of phagocytosis
GO:0045859  regulation of protein kinase activity
GO:0009615  response to virus

Cellular Component

GO:0015629  actin cytoskeleton
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0005743  mitochondrial inner membrane
GO:0005758  mitochondrial intermembrane space
GO:0005886  plasma membrane
GO:0032587  ruffle membrane

Molecular Function

GO:0005524  ATP binding
GO:0034988  Fc-gamma receptor I complex binding
GO:0034987  immunoglobulin receptor binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0001784  phosphotyrosine binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004713  protein tyrosine kinase activity