FK506 binding protein 1B, 12.6 kDa

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Synonym

FKBP12.6, Rotamase 1B, Immunophilin FKBP12.6, 12.6 kDa FKBP, FKBP1B, FK506-binding protein 1B (12.6 kD), PPIase 1B, FK506-binding protein 1B, FK506 binding protein 1B, 12.6 kDa, FKBP-12.6, Peptidyl-prolyl cis-trans isomerase 1B, PKBP1L, OTK4, h-FKBP-12, FKBP1L

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:7.49 cerebellum:7.35 brain stem:7.26 corpus callosum/glia:5.22 pineal gland:- peripheral nerve:9.70 spine:6.14 retina:- eye:- artery/aorta:5.85 vein:4.96 lymphnode:4.66 peripheral blood:- spleen:4.29 thymus:4.19 bone marrow:5.57 adipose:4.94 bone:- skin:5.33
CAGE cerebrum:3.47 cerebellum:- brain stem:2.24 corpus callosum/glia:1.70 pineal gland:2.11 peripheral nerve:- spine:2.34 retina:- eye:- artery/aorta:2.12 vein:1.34 lymphnode:1.29 peripheral blood:- spleen:1.39 thymus:1.12 bone marrow:- adipose:1.60 bone:- skin:-
RNA-seq cerebrum:1.22 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.18 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.13 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.26 placenta:5.05 prostate:6.28 ovary:5.08 testis:4.54 heart:5.12 muscle:4.41 esophagus:5.46 stomach:6.36 intestine:5.72 colon:5.52 liver/hepato:4.51 lung:6.55 bladder:- kidney:5.43 pituitary:5.17 thyroid/parathyroid:6.06 adrenal gland:4.91 pancreas:5.65 breast:5.25 salivary:5.09
CAGE uterus:1.68 placenta:1.55 prostate:1.97 ovary:1.82 testis:1.48 heart:1.80 muscle:1.15 esophagus:2.18 stomach:- intestine:2.67 colon:2.73     liver/hepato:1.95    lung:2.51 bladder:1.89 kidney:2.23 pituitary:1.67 thyroid/parathyroid:2.48 adrenal gland:- pancreas:1.59 breast:2.74 salivary:1.75
RNA-seq uterus:- placenta:- prostate:0.77 ovary:0.97 testis:0.83 heart:0.76 muscle:0.38 esophagus:- stomach:- intestine:- colon:1.85     liver/hepato:0.66        lung:2.30    bladder:- kidney:1.20 pituitary:- thyroid/parathyroid:0.55 adrenal gland:0.04 pancreas:- breast:0.48 salivary:-

Gene Information

IDs

Refseq ID NM_054033
Gene ID 2281
Unigene ID -
Probe set ID 206857_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000119782
GTEx ID ENSG00000119782

Orthologous Gene

Mouse[1]  NM_016863
Rat[1]  NM_016863

Chromosomal Region

2p23.3  [24,272,571  -  24,286,551]

Gene Family (Interpro ID)

IPR001179  Peptidyl-prolyl cis-trans isomerase, FKBP-type

Link to Pubmed  (Pubmed ID)

7513996
7592869
9013543
10713512
10830164
11237759
11322937
12443530
12446682
12459180
12477932
12754204
14616768
15351706
15489334
15497458
15591045
15749201
15972811
16122887
17200109
17313373
17506935
17921453
19197348
19226252
20404344
20431056
22087651
22236651
23887639

Gene Ontology  (GO ID)

Biological Process

GO:0006458  'de novo' protein folding
GO:0051480  cytosolic calcium ion homeostasis
GO:0030073  insulin secretion
GO:0006936  muscle contraction
GO:0010459  negative regulation of heart rate
GO:0032513  negative regulation of protein phosphatase type 2B activity
GO:0051280  negative regulation of release of sequestered calcium ion into cytosol
GO:0060315  negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0019227  neuronal action potential propagation
GO:0018208  peptidyl-proline modification
GO:0051284  positive regulation of sequestering of calcium ion
GO:0022417  protein maturation by protein folding
GO:0000413  protein peptidyl-prolyl isomerization
GO:0042026  protein refolding
GO:0010881  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010880  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0060314  regulation of ryanodine-sensitive calcium-release channel activity
GO:0014808  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0009749  response to glucose stimulus
GO:0042542  response to hydrogen peroxide
GO:0051775  response to redox state
GO:0033197  response to vitamin E
GO:0006939  smooth muscle contraction
GO:0042098  T cell proliferation

Cellular Component

GO:0034704  calcium channel complex
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016020  membrane
GO:0033017  sarcoplasmic reticulum membrane
GO:0030018  Z disc

Molecular Function

GO:0019855  calcium channel inhibitor activity
GO:0030551  cyclic nucleotide binding
GO:0005528  FK506 binding
GO:0003755  peptidyl-prolyl cis-trans isomerase activity
GO:0005515  protein binding
GO:0005102  receptor binding
GO:0005219  ryanodine-sensitive calcium-release channel activity