zinc fingers and homeoboxes 2

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Synonym

KIAA0854, Alpha-fetoprotein regulator 1, ZHX2, zinc fingers and homeoboxes 2, zinc-fingers and homeoboxes 2, Zinc fingers and homeoboxes protein 2, RAF, AFR1, Regulator of AFP, AFP regulator 1, Zinc finger and homeodomain protein 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.94 cerebellum:6.62 brain stem:6.84 corpus callosum/glia:7.87 pineal gland:- peripheral nerve:7.05 spine:7.51 retina:- eye:- artery/aorta:7.23 vein:7.55 lymphnode:7.83 peripheral blood:- spleen:7.81 thymus:6.74 bone marrow:6.18 adipose:6.94 bone:- skin:6.59
CAGE cerebrum:3.04 cerebellum:- brain stem:3.08 corpus callosum/glia:3.57 pineal gland:2.40 peripheral nerve:- spine:3.41 retina:- eye:- artery/aorta:3.42 vein:3.23 lymphnode:3.38 peripheral blood:- spleen:3.20 thymus:3.20 bone marrow:- adipose:2.81 bone:- skin:-
RNA-seq cerebrum:3.08 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.71 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.06 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.38 placenta:5.57 prostate:7.64 ovary:7.63 testis:5.32 heart:7.26 muscle:7.66 esophagus:6.50 stomach:6.62 intestine:6.86 colon:6.48 liver/hepato:7.17 lung:6.92 bladder:- kidney:6.69 pituitary:7.10 thyroid/parathyroid:7.41 adrenal gland:6.88 pancreas:6.46 breast:7.56 salivary:6.96
CAGE uterus:2.96 placenta:1.82 prostate:3.37 ovary:3.42 testis:2.25 heart:3.17 muscle:3.43 esophagus:2.72 stomach:- intestine:2.57 colon:2.42     liver/hepato:2.82    lung:3.23 bladder:3.37 kidney:2.72 pituitary:2.92 thyroid/parathyroid:3.08 adrenal gland:- pancreas:3.37 breast:2.99 salivary:3.01
RNA-seq uterus:- placenta:- prostate:3.65 ovary:3.82 testis:2.90 heart:3.35 muscle:4.07 esophagus:- stomach:- intestine:- colon:2.70     liver/hepato:2.25        lung:3.90    bladder:- kidney:2.51 pituitary:- thyroid/parathyroid:3.88 adrenal gland:3.83 pancreas:- breast:2.89 salivary:-

Gene Information

IDs

Refseq ID NM_014943
Gene ID 22882
Unigene ID -
Probe set ID 203556_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000178764
GTEx ID ENSG00000178764

Orthologous Gene

Mouse[1]  NM_199449
Rat[1]  NM_199449

Chromosomal Region

8q24.13  [123,793,633  -  123,986,750]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related
IPR015880  Zinc finger, C2H2-like
IPR007087  Zinc finger, C2H2-type

Link to Pubmed  (Pubmed ID)

8051160
9092538
10048485
11205744
12477932
12741956
14659886
15489334
15824104
16713569
16952470
16968750
17056598
17447851
17533377
18029348
18194454
19240061
19805522
20080650
20379614
21443521
21832049
21909108
21987443
21988832
22078940
22542470
22661463
22984075
23942779
24583282

Gene Ontology  (GO ID)

Biological Process

GO:0006402  mRNA catabolic process
GO:0045665  negative regulation of neuron differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0035019  somatic stem cell maintenance
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0043565  sequence-specific DNA binding
GO:0003714  transcription corepressor activity
GO:0003700  transcription factor activity