caspase recruitment domain family, member 8

Synonym

NDPP1, CARDINAL, Caspase recruitment domain-containing protein 8, KIAA0955, TUCAN, MGC57162, caspase recruitment domain family, member 8, CARD-inhibitor of NF-kappa-B-activating ligand, Apoptotic protein NDPP1, DACAR, CARD8

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:22.50

cerebellum:12.60

brain stem:-

corpus callosum/glia:-

pineal gland:148.30

peripheral nerve:30.70

spine:112.30

retina:-

eye:47

artery/aorta:89.90

vein:-

lymphnode:141.50

peripheral blood:36.40

spleen:151.30

thymus:141.70

bone marrow:216.50

adipose:-

bone:25.60

skin:38.40

GeneChip

cerebrum:4.95

cerebellum:5.11

brain stem:4.99

corpus callosum/glia:5.15

pineal gland:-

peripheral nerve:5.21

spine:5.19

retina:-

eye:-

artery/aorta:5.35

vein:5.28

lymphnode:6.64

peripheral blood:-

spleen:7.18

thymus:6.71

bone marrow:6.28

adipose:5.76

bone:-

skin:5.46

CAGE

cerebrum:2.38

cerebellum:-

brain stem:2.91

corpus callosum/glia:2.98

pineal gland:2.98

peripheral nerve:-

spine:3.30

retina:-

eye:-

artery/aorta:2.86

vein:3.85

lymphnode:3.83

peripheral blood:-

spleen:4.32

thymus:3.62

bone marrow:-

adipose:4.17

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.19

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.51

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:100.20

placenta:29.10

prostate:22.50

ovary:37.30

testis:43.30

heart:63.90

muscle:80.40

esophagus:-

stomach:-

intestine:-

colon:59.40

liver/hepato:21.10

lung:24.40

bladder:-

kidney:31.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:46.50

salivary:328.40

GeneChip

uterus:5.63

placenta:5.63

prostate:5.26

ovary:5.50

testis:5.46

heart:5.56

muscle:5.26

esophagus:5.01

stomach:5.60

intestine:5.45

colon:5.28

liver/hepato:5.24

lung:6.30

bladder:-

kidney:5.16

pituitary:5.19

thyroid/parathyroid:5.65

adrenal gland:5.31

pancreas:5.17

breast:5.50

salivary:5.04

CAGE

uterus:3.30

placenta:3.20

prostate:2.99

ovary:2.68

testis:3.20

heart:3.26

muscle:2.83

esophagus:2.57

stomach:-

intestine:2.75

colon:2.74

liver/hepato:2.46

lung:3.67

bladder:2.81

kidney:2.76

pituitary:2.74

thyroid/parathyroid:2.99

adrenal gland:-

pancreas:2.60

breast:3.43

salivary:2.06

RNA-seq

uterus:-

placenta:-

prostate:2.04

ovary:1.29

testis:1.54

heart:1.29

muscle:1.55

esophagus:-

stomach:-

intestine:-

colon:1.35

liver/hepato:0.68

lung:2.72

bladder:-

kidney:1.74

pituitary:-

thyroid/parathyroid:1.24

adrenal gland:0.67

pancreas:-

breast:0.91

salivary:-

IDs

Refseq ID	NM_014959
Gene ID	22900
Unigene ID	Hs.446146
Probe set ID	204950_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000105483
GTEx ID	ENSG00000105483

Orthologous Gene

Mouse [0]
Rat [0]

Chromosomal Region

19q13.33 [48,706,403 - 48,759,203]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001315	Caspase Recruitment
IPR011029	DEATH-like

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043280	positive regulation of caspase activity
GO:0050718	positive regulation of interleukin-1 beta secretion

Cellular Component

GO:0005737	cytoplasm
GO:0005634	nucleus

Molecular Function

GO:0008656	caspase activator activity
GO:0032089	NACHT domain binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

caspase recruitment domain family, member 8

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function