forkhead box F1

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Synonym

FOXF1, FREAC-1, FKHL5, Forkhead-related transcription factor 1, Forkhead-related protein FKHL5, MGC105125, Forkhead box protein F1, forkhead box F1, FREAC1, Forkhead-related activator 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.52 cerebellum:4.04 brain stem:4.63 corpus callosum/glia:4.47 pineal gland:- peripheral nerve:3.99 spine:4.83 retina:- eye:- artery/aorta:4.71 vein:4.43 lymphnode:5.44 peripheral blood:- spleen:4.33 thymus:3.75 bone marrow:3.97 adipose:4.97 bone:- skin:4.29
CAGE cerebrum:1.59 cerebellum:- brain stem:2.12 corpus callosum/glia:1.60 pineal gland:1.17 peripheral nerve:- spine:1.95 retina:- eye:- artery/aorta:1.52 vein:1.17 lymphnode:1.69 peripheral blood:- spleen:0.09 thymus:0.12 bone marrow:- adipose:0.26 bone:- skin:-
RNA-seq cerebrum:0.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.08 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.76 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:14.60 prostate:33.80 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:29.30    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:- salivary:-
GeneChip uterus:5.40 placenta:6.84 prostate:7.14 ovary:3.88 testis:3.99 heart:4.36 muscle:4.05 esophagus:5.60 stomach:8.19 intestine:6.99 colon:8.38 liver/hepato:4.65 lung:8.52 bladder:- kidney:4.54 pituitary:3.79 thyroid/parathyroid:5.09 adrenal gland:4.02 pancreas:4.52 breast:3.91 salivary:4.08
CAGE uterus:2.41 placenta:3.33 prostate:4.57 ovary:1.18 testis:0.33 heart:0.81 muscle:0.13 esophagus:3.88 stomach:- intestine:3.85 colon:4.33     liver/hepato:1.93    lung:4.68 bladder:4.85 kidney:0.74 pituitary:0 thyroid/parathyroid:1.53 adrenal gland:- pancreas:0 breast:0.90 salivary:0.83
RNA-seq uterus:- placenta:- prostate:5.58 ovary:0.93 testis:1.09 heart:0.09 muscle:0.20 esophagus:- stomach:- intestine:- colon:4.48     liver/hepato:0.57        lung:5.45    bladder:- kidney:0.70 pituitary:- thyroid/parathyroid:0.99 adrenal gland:2.37 pancreas:- breast:0.30 salivary:-

Gene Information

IDs

Refseq ID NM_001451
Gene ID 2294
Unigene ID Hs.155591
Probe set ID 205935_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000103241
GTEx ID ENSG00000103241

Orthologous Gene

Mouse[2]  NM_010426
Rat[2]  NM_010426

Chromosomal Region

16q24.1  [86,544,144  -  86,548,076]

Gene Family (Interpro ID)

IPR001766  Transcription factor, fork head
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

7957066
7959731
8626802
8825632
9722567
9769171
12477932
15489334
16344560
16448649
16772323
18564921
19500772
19822228
19851296
20145151
20198315
20233876
20549505
21271214
21315191
21964066
22961001
23034409
23103611
23322567
23407133
23504527
23505205
23563609
23864317
23943206
24121790

Gene Ontology  (GO ID)

Biological Process

GO:0001568  blood vessel development
GO:0060441  branching involved in lung morphogenesis
GO:0060446  branching involved in open tracheal system development
GO:0003214  cardiac left ventricle morphogenesis
GO:0016337  cell-cell adhesion
GO:0071345  cellular response to cytokine stimulus
GO:0071407  cellular response to organic cyclic substance
GO:0014822  detection of wounding
GO:0007368  determination of left/right symmetry
GO:0009790  embryonic development
GO:0048557  embryonic digestive tract morphogenesis
GO:0048613  embryonic ectodermal gut morphogenesis
GO:0048617  embryonic foregut morphogenesis
GO:0003197  endocardial cushion development
GO:0045198  establishment of epithelial cell apical/basal polarity
GO:0030198  extracellular matrix organization
GO:0048565  gut development
GO:0007507  heart development
GO:0001701  in utero embryonic development
GO:0048371  lateral mesodermal cell differentiation
GO:0048286  lung alveolus development
GO:0030324  lung development
GO:0060463  lung lobe morphogenesis
GO:0060426  lung vasculature development
GO:0090131  mesenchyme migration
GO:0007494  midgut development
GO:0001763  morphogenesis of a branching structure
GO:0050728  negative regulation of inflammatory response
GO:0043305  negative regulation of mast cell degranulation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0031016  pancreas development
GO:0007389  pattern specification process
GO:0030335  positive regulation of cell migration
GO:0010811  positive regulation of cell-substrate adhesion
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0051150  regulation of smooth muscle cell differentiation
GO:0051090  regulation of transcription factor activity
GO:0030323  respiratory tube development
GO:0060461  right lung morphogenesis
GO:0051145  smooth muscle cell differentiation
GO:0007224  smoothened signaling pathway
GO:0001756  somitogenesis
GO:0009888  tissue development
GO:0060438  trachea development
GO:0001570  vasculogenesis
GO:0060841  venous blood vessel development

Cellular Component

GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0008134  transcription factor binding