forkhead box C1

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Synonym

IRID1, IGDA, forkhead box C1, FREAC3, FKHL7, IHG1, FOXC1, FREAC-3, Forkhead-related protein FKHL7, ARA, Forkhead-related transcription factor 3, Forkhead box protein C1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:552.10 spine:- retina:- eye:58.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:102.40 skin:-
GeneChip cerebrum:6.29 cerebellum:6.05 brain stem:6.35 corpus callosum/glia:6.13 pineal gland:- peripheral nerve:7.95 spine:6.58 retina:- eye:- artery/aorta:8.48 vein:8.09 lymphnode:5.99 peripheral blood:- spleen:5.33 thymus:5.90 bone marrow:6.42 adipose:6.75 bone:- skin:6.83
CAGE cerebrum:1.00 cerebellum:- brain stem:1.29 corpus callosum/glia:1.52 pineal gland:1.44 peripheral nerve:- spine:1.43 retina:- eye:- artery/aorta:4.55 vein:2.47 lymphnode:1.17 peripheral blood:- spleen:0.09 thymus:1.26 bone marrow:- adipose:2.03 bone:- skin:-
RNA-seq cerebrum:1.75 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.27 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.22 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:18.20 prostate:56.30 ovary:- testis:8.70 heart:76.60 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:24.40    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:9.30 salivary:-
GeneChip uterus:6.06 placenta:5.96 prostate:6.49 ovary:6.14 testis:5.77 heart:6.85 muscle:6.34 esophagus:6.38 stomach:5.95 intestine:6.20 colon:6.24 liver/hepato:5.76 lung:6.13 bladder:- kidney:7.77 pituitary:6.46 thyroid/parathyroid:6.12 adrenal gland:6.53 pancreas:6.45 breast:7.09 salivary:10.13
CAGE uterus:1.86 placenta:0.99 prostate:2.17 ovary:1.83 testis:1.89 heart:2.01 muscle:0.83 esophagus:1.75 stomach:- intestine:0.57 colon:0.82     liver/hepato:0    lung:1.53 bladder:2.08 kidney:2.20 pituitary:1.53 thyroid/parathyroid:1.53 adrenal gland:- pancreas:0.94 breast:2.64 salivary:3.92
RNA-seq uterus:- placenta:- prostate:3.04 ovary:2.45 testis:3.40 heart:1.68 muscle:1.74 esophagus:- stomach:- intestine:- colon:1.82     liver/hepato:0.19        lung:3.36    bladder:- kidney:4.21 pituitary:- thyroid/parathyroid:2.26 adrenal gland:3.02 pancreas:- breast:2.65 salivary:-

Gene Information

IDs

Refseq ID NM_001453
Gene ID 2296
Unigene ID Hs.348883
Probe set ID 213260_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000054598
GTEx ID ENSG00000054598

Orthologous Gene

Mouse[2]  NM_008592
Rat[2]  NM_008592

Chromosomal Region

6p25.3  [1,610,679  -  1,614,127]

Gene Family (Interpro ID)

IPR001766  Transcription factor, fork head
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

7957066
8499623
8825632
8940278
9326342
9382099
9620769
9792859
10474162
10713890
11007653
11170889
11179011
11237714
11320352
11562355
11740218
11748221
11782474
11821690
12234674
12408963
12454026
12477932
12592227
12614756
14506133
14574404
14578375
14702039
15277473
15299087
15477465
15684392
16449236
16492674
16638984
16936096
16952980
17000708
17157569
17197537
17486624
17558846
17653043
17993506
18029348
18484311
18498376
18564921
18616618
18676636
18676680
18708620
19170196
19279310
19322201
19471022
19513095
19625176
19626132
19668217
19692168
19793056
19913121
20056007
20338046
20406990
20453000
20628086
20881294
21031026
21139048
21278591
21353197
21400511
21424368
21465172
21693764
21837767
22020760
22120723
22190034
22249250
22493429
22569110
22645147
22736943
22903608
22911555
22991501
23242609
23264086
23444221
23541832
23667531
23687430

Gene Ontology  (GO ID)

Biological Process

GO:0048844  artery morphogenesis
GO:0001974  blood vessel remodeling
GO:0007420  brain development
GO:0043010  camera-type eye development
GO:0060038  cardiac muscle cell proliferation
GO:0030199  collagen fibril organization
GO:0035050  embryonic heart tube development
GO:0001654  eye development
GO:0008354  germ cell migration
GO:0030203  glycosaminoglycan metabolic process
GO:0007507  heart development
GO:0001701  in utero embryonic development
GO:0032808  lacrimal gland development
GO:0001946  lymphangiogenesis
GO:0001656  metanephros development
GO:0043066  negative regulation of apoptosis
GO:0045930  negative regulation of mitotic cell cycle
GO:0014032  neural crest cell development
GO:0014034  neural crest cell fate commitment
GO:0007219  Notch signaling pathway
GO:0042475  odontogenesis of dentine-containing tooth
GO:0001503  ossification
GO:0001541  ovarian follicle development
GO:0048343  paraxial mesodermal cell fate commitment
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0050880  regulation of blood vessel size
GO:0046620  regulation of organ growth
GO:0051090  regulation of transcription factor activity
GO:0006355  regulation of transcription, DNA-dependent
GO:0001501  skeletal system development
GO:0001756  somitogenesis
GO:0001657  ureteric bud development
GO:0048010  vascular endothelial growth factor receptor signaling pathway
GO:0001570  vasculogenesis
GO:0055010  ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0005737  cytoplasm
GO:0005720  nuclear heterochromatin
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0031490  chromatin DNA binding
GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0005515  protein binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding