forkhead box C2 (MFH-1, mesenchyme forkhead 1)

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Synonym

Transcription factor FKH-14, MFH1, Forkhead-related protein FKHL14, FOXC2, Forkhead box protein C2, Mesenchyme fork head protein 1, forkhead box C2 (MFH-1, mesenchyme forkhead 1), FKHL14, MFH-1, MFH-1 protein

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:92 spine:- retina:- eye:23.50 artery/aorta:30 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:3.99 cerebellum:3.85 brain stem:4.20 corpus callosum/glia:3.85 pineal gland:- peripheral nerve:4.05 spine:3.76 retina:- eye:- artery/aorta:4.55 vein:4.24 lymphnode:3.90 peripheral blood:- spleen:3.60 thymus:3.50 bone marrow:4.01 adipose:3.97 bone:- skin:3.87
CAGE cerebrum:0.85 cerebellum:- brain stem:1.84 corpus callosum/glia:1.38 pineal gland:1.08 peripheral nerve:- spine:2.24 retina:- eye:- artery/aorta:4.81 vein:2.54 lymphnode:1.41 peripheral blood:- spleen:0 thymus:0.33 bone marrow:- adipose:1.29 bone:- skin:-
RNA-seq cerebrum:0.11 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.23 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.28 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:3.72 placenta:3.74 prostate:3.57 ovary:3.83 testis:3.68 heart:4.13 muscle:4.16 esophagus:3.78 stomach:3.88 intestine:4.05 colon:4.04 liver/hepato:3.87 lung:3.87 bladder:- kidney:4.03 pituitary:3.94 thyroid/parathyroid:3.74 adrenal gland:4.24 pancreas:4.29 breast:3.66 salivary:4.06
CAGE uterus:1.49 placenta:0.81 prostate:1.40 ovary:1.79 testis:2.22 heart:2.63 muscle:1.06 esophagus:1.60 stomach:- intestine:0.90 colon:0.68     liver/hepato:0    lung:1.94 bladder:1.88 kidney:2.35 pituitary:1.52 thyroid/parathyroid:1.50 adrenal gland:- pancreas:0 breast:2.02 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0.42 ovary:0.21 testis:1.56 heart:0.37 muscle:0.16 esophagus:- stomach:- intestine:- colon:0.11     liver/hepato:0        lung:1.29    bladder:- kidney:1.14 pituitary:- thyroid/parathyroid:0.41 adrenal gland:0.86 pancreas:- breast:0.25 salivary:-

Gene Information

IDs

Refseq ID NM_005251
Gene ID 2303
Unigene ID Hs.436448
Probe set ID 214520_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000176692
GTEx ID ENSG00000176692

Orthologous Gene

Mouse[1]  NM_013519
Rat[1]  NM_013519

Chromosomal Region

16q24.1  [86,600,857  -  86,602,539]

Gene Family (Interpro ID)

IPR001766  Transcription factor, fork head
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

8674414
9169153
10417285
10669593
11076863
11078474
11371511
11499682
11551504
11562355
11694548
12114478
12383817
12453913
12477932
12485195
12540636
12716768
14530861
15198934
15489334
15523639
15597109
15601967
15919786
15926113
16081467
16456100
16786163
16952980
17081983
17342473
17372167
17537911
18197197
18564920
18660489
18973153
18974842
18986489
19013876
19056482
19185813
19336002
19339011
19394045
19453261
19471022
19548265
19760751
19876004
19935708
20060810
20201926
20218083
20301630
20450314
20460685
20535019
20540670
20552815
20634891
20803080
21270254
21457232
21464574
21640215
21693764
21918810
22178381
22216698
22349027
22374725
22410781
22493429
23378344
23614500
23878394
23919841
24276887

Gene Ontology  (GO ID)

Biological Process

GO:0048844  artery morphogenesis
GO:0001974  blood vessel remodeling
GO:0043010  camera-type eye development
GO:0060038  cardiac muscle cell proliferation
GO:0030199  collagen fibril organization
GO:0035050  embryonic heart tube development
GO:0048703  embryonic viscerocranium morphogenesis
GO:0007507  heart development
GO:0008286  insulin receptor signaling pathway
GO:0001946  lymphangiogenesis
GO:0007498  mesoderm development
GO:0001656  metanephros development
GO:0043066  negative regulation of apoptosis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0014032  neural crest cell development
GO:0014034  neural crest cell fate commitment
GO:0007219  Notch signaling pathway
GO:0001503  ossification
GO:0048343  paraxial mesodermal cell fate commitment
GO:0001569  patterning of blood vessels
GO:0033630  positive regulation of cell adhesion mediated by integrin
GO:0090050  positive regulation of cell migration involved in sprouting angiogenesis
GO:0010595  positive regulation of endothelial cell migration
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0050880  regulation of blood vessel size
GO:0046620  regulation of organ growth
GO:0051090  regulation of transcription factor activity
GO:0009725  response to hormone stimulus
GO:0001756  somitogenesis
GO:0001657  ureteric bud development
GO:0048010  vascular endothelial growth factor receptor signaling pathway
GO:0001570  vasculogenesis
GO:0055010  ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0031490  chromatin DNA binding
GO:0008301  DNA bending activity
GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding