forkhead box S1

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Synonym

FREAC-10, FREAC10, MGC4544, forkhead-like 18 (Drosophila), Forkhead-related transcription factor 10, FKHL18, forkhead (Drosophila)-like 18, Forkhead-like 18 protein

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:0.85 cerebellum:- brain stem:1.07 corpus callosum/glia:1.59 pineal gland:1.14 peripheral nerve:- spine:0.87 retina:- eye:- artery/aorta:4.50 vein:2.18 lymphnode:1.12 peripheral blood:- spleen:1.26 thymus:1.10 bone marrow:- adipose:0.96 bone:- skin:-
RNA-seq cerebrum:0.13 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.42 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.50 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:7.30 prostate:33.80 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE uterus:2.52 placenta:2.45 prostate:1.63 ovary:1.53 testis:1.94 heart:1.57 muscle:1.40 esophagus:1.31 stomach:- intestine:0.48 colon:1.01     liver/hepato:0.26    lung:1.79 bladder:1.56 kidney:1.37 pituitary:0.10 thyroid/parathyroid:1.11 adrenal gland:- pancreas:0.58 breast:2.41 salivary:0.83
RNA-seq uterus:- placenta:- prostate:0.81 ovary:0.98 testis:2.35 heart:0.37 muscle:0.47 esophagus:- stomach:- intestine:- colon:0.09     liver/hepato:0.04        lung:1.40    bladder:- kidney:0.92 pituitary:- thyroid/parathyroid:0.31 adrenal gland:1.26 pancreas:- breast:1.15 salivary:-

Gene Information

IDs

Refseq ID NM_004118
Gene ID 2307
Unigene ID Hs.516971
Probe set ID -
Ensembl ID ENSG00000179772
GTEx ID ENSG00000179772

Orthologous Gene

Mouse[1]  NM_010226
Rat [0]  

Chromosomal Region

20q11.21  [30,432,103  -  30,433,420]

Gene Family (Interpro ID)

IPR001766  Transcription factor, fork head
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

9325056
11780052
12477932
15489334
16189514
17062144
20211142
21832049

Gene Ontology  (GO ID)

Biological Process

GO:0048844  artery morphogenesis
GO:0001568  blood vessel development
GO:0001974  blood vessel remodeling
GO:0043010  camera-type eye development
GO:0060038  cardiac muscle cell proliferation
GO:0030199  collagen fibril organization
GO:0035050  embryonic heart tube development
GO:0048703  embryonic viscerocranium morphogenesis
GO:0008286  insulin receptor signaling pathway
GO:0001946  lymphangiogenesis
GO:0001656  metanephros development
GO:0007275  multicellular organismal development
GO:0043433  negative regulation of transcription factor activity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0014034  neural crest cell fate commitment
GO:0050885  neuromuscular process controlling balance
GO:0007219  Notch signaling pathway
GO:0001503  ossification
GO:0048343  paraxial mesodermal cell fate commitment
GO:0001569  patterning of blood vessels
GO:0040018  positive regulation of multicellular organism growth
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0050880  regulation of blood vessel size
GO:0046620  regulation of organ growth
GO:0006355  regulation of transcription, DNA-dependent
GO:0001756  somitogenesis
GO:0001657  ureteric bud development
GO:0048010  vascular endothelial growth factor receptor signaling pathway
GO:0001570  vasculogenesis
GO:0055010  ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0031490  chromatin DNA binding
GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0003690  double-stranded DNA binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding