proteasome (prosome, macropain) activator subunit 4

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Synonym

MGC142228, MGC138374, FLJ21864, PA200, KIAA0077, PSME4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:40.30 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:224.60 retina:- eye:64.60 artery/aorta:- vein:- lymphnode:80.90 peripheral blood:18.20 spleen:18.90 thymus:90.20 bone marrow:59 adipose:80.70 bone:89.60 skin:153.60
GeneChip cerebrum:6.50 cerebellum:6.28 brain stem:6.53 corpus callosum/glia:7 pineal gland:- peripheral nerve:6.10 spine:6.11 retina:- eye:- artery/aorta:6.05 vein:6.48 lymphnode:5.96 peripheral blood:- spleen:6.41 thymus:6.05 bone marrow:5.53 adipose:5.58 bone:- skin:6.10
CAGE cerebrum:2.26 cerebellum:- brain stem:2.54 corpus callosum/glia:2.90 pineal gland:2.39 peripheral nerve:- spine:2.36 retina:- eye:- artery/aorta:2.68 vein:2.62 lymphnode:2.87 peripheral blood:- spleen:2.47 thymus:2.60 bone marrow:- adipose:3.03 bone:- skin:-
RNA-seq cerebrum:2.53 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.01 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.10 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:109.40 placenta:47.40 prostate:101.40 ovary:37.30 testis:160.10 heart:38.30 muscle:100.50 esophagus:- stomach:148.70 intestine:32.40 colon:127.20     liver/hepato:84.40        lung:63.50    bladder:125.60 kidney:20.80 pituitary:- thyroid/parathyroid:327.50 adrenal gland:- pancreas:17.80 breast:120.80 salivary:-
GeneChip uterus:7.37 placenta:5.61 prostate:7.11 ovary:6.69 testis:7.02 heart:6.97 muscle:8.39 esophagus:6.23 stomach:6.32 intestine:6.17 colon:5.17 liver/hepato:6.25 lung:5.92 bladder:- kidney:5.70 pituitary:6.57 thyroid/parathyroid:6.53 adrenal gland:6.21 pancreas:4.86 breast:6.70 salivary:6.18
CAGE uterus:2.99 placenta:2.40 prostate:2.48 ovary:2.12 testis:3.35 heart:3.55 muscle:3.79 esophagus:2.58 stomach:- intestine:2.23 colon:2.85     liver/hepato:2.41    lung:2.94 bladder:2.83 kidney:2.17 pituitary:2.44 thyroid/parathyroid:2.35 adrenal gland:- pancreas:2.26 breast:3.06 salivary:2.80
RNA-seq uterus:- placenta:- prostate:3.09 ovary:3.23 testis:4.74 heart:4.35 muscle:4.88 esophagus:- stomach:- intestine:- colon:2.54     liver/hepato:3.12        lung:3.21    bladder:- kidney:2.81 pituitary:- thyroid/parathyroid:4.25 adrenal gland:3.34 pancreas:- breast:3.38 salivary:-

Gene Information

IDs

Refseq ID NM_014614
Gene ID 23198
Unigene ID Hs.413801
Probe set ID 212222_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000068878
GTEx ID ENSG00000068878

Orthologous Gene

Mouse[3]  NM_134013
Rat [0]  

Chromosomal Region

2p16.2  [54,091,204  -  54,197,977]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7584044
9079628
9811770
9846577
10893419
11285280
12093752
12167863
12419264
12477932
12719574
12750511
12791267
12808465
12808466
12809610
12830140
12840737
12859895
12914693
12920286
12970355
14527406
14528300
14528301
14550573
14557625
14564014
14614829
15489334
16344560
17314511
17323924
17523843
19013454
19193609
20379614
21139048
21145461
21697133
21890473
21906983
21963094
21987572
22863883
23000965
24811749
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0031145  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590  antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474  antigen processing and presentation of peptide antigen via MHC class I
GO:0006915  apoptosis
GO:0034641  cellular nitrogen compound metabolic process
GO:0006977  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006281  DNA repair
GO:0010467  gene expression
GO:0000278  mitotic cell cycle
GO:0016071  mRNA metabolic process
GO:0007275  multicellular organismal development
GO:0043066  negative regulation of apoptosis
GO:0010952  positive regulation of peptidase activity
GO:0051437  positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0010499  proteasomal ubiquitin-independent protein catabolic process
GO:0000209  protein polyubiquitination
GO:0042981  regulation of apoptosis
GO:0006521  regulation of cellular amino acid metabolic process
GO:0051439  regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0006974  response to DNA damage stimulus
GO:0016070  RNA metabolic process
GO:0035093  spermatogenesis, exchange of chromosomal proteins
GO:0016032  viral reproduction

Cellular Component

GO:0005829  cytosol
GO:0016607  nuclear speck
GO:0005634  nucleus

Molecular Function

GO:0070577  histone acetyl-lysine binding
GO:0016504  peptidase activator activity