spectrin repeat containing, nuclear envelope 2

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Synonym

Nucleus and actin connecting element protein, NUANCE, DKFZP434H2235, FLJ46790, KIAA1011, Synaptic nuclear envelope protein 2, Nuclear envelope spectrin repeat protein 2, NUA, FLJ11014, Protein NUANCE, DKFZp686H1931, SYNE2, SYNE-2, FLJ45710, spectrin repeat containing, nuclear envelope 2, Syne-2, Nesprin-2, FLJ43727

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.66 cerebellum:6.57 brain stem:4.67 corpus callosum/glia:4.72 pineal gland:- peripheral nerve:6.45 spine:4.81 retina:- eye:- artery/aorta:6.84 vein:6.55 lymphnode:7.11 peripheral blood:- spleen:7.22 thymus:7.24 bone marrow:6 adipose:7.09 bone:- skin:7.51
CAGE cerebrum:2.73 cerebellum:- brain stem:2.60 corpus callosum/glia:2.41 pineal gland:3.18 peripheral nerve:- spine:2.78 retina:- eye:- artery/aorta:4.09 vein:3.76 lymphnode:3.93 peripheral blood:- spleen:4.06 thymus:4.11 bone marrow:- adipose:4.84 bone:- skin:-
RNA-seq cerebrum:0.42 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.95 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.82 placenta:8.25 prostate:6.66 ovary:8.02 testis:7.56 heart:8.07 muscle:8.86 esophagus:7.66 stomach:6.64 intestine:7.82 colon:6.85 liver/hepato:6.08 lung:7.44 bladder:- kidney:8.40 pituitary:7.55 thyroid/parathyroid:8.49 adrenal gland:6.44 pancreas:7.44 breast:7.25 salivary:6.81
CAGE uterus:4.35 placenta:4.00 prostate:4.05 ovary:4.36 testis:4.26 heart:4.35 muscle:5.20 esophagus:4.24 stomach:- intestine:3.69 colon:4.04     liver/hepato:2.57    lung:4.27 bladder:3.81 kidney:5.03 pituitary:4.16 thyroid/parathyroid:4.72 adrenal gland:- pancreas:3.67 breast:4.79 salivary:3.59
RNA-seq uterus:- placenta:- prostate:0.93 ovary:0.38 testis:0.00 heart:2.26 muscle:3.48 esophagus:- stomach:- intestine:- colon:1.89     liver/hepato:0.00        lung:0.83    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:2.54 adrenal gland:1.08 pancreas:- breast:1.43 salivary:-

Gene Information

IDs

Refseq ID NM_182914
Gene ID 23224
Unigene ID -
Probe set ID 202761_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000054654
GTEx ID ENSG00000054654

Orthologous Gene

Mouse[1]  NM_001005510
Rat[1]  NM_001005510

Chromosomal Region

14q23.2  [64,319,683  -  64,693,165]

Gene Family (Interpro ID)

IPR016146  Calponin-homology
IPR001715  Calponin-like actin-binding
IPR018159  Spectrin/alpha-actinin

Link to Pubmed  (Pubmed ID)

10231032
10878022
11230166
11792814
12118075
12168954
12408964
12477932
12508121
12958361
14702039
15489334
15671068
15790807
15840729
15843432
16079285
16344560
17081983
17462627
17761684
17881656
18029348
18396275
18477613
18827015
19596235
19861416
19933576
20108321
20237496
20379614
20801886
20811636
21139048
21820406
21853274
21900206
22424883
22505724
22544366
22586326
22632968
22768332
22939629
23314748
23707952
23752268
23977161
24080406
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0051642  centrosome localization
GO:0007163  establishment or maintenance of cell polarity
GO:0010761  fibroblast migration
GO:0006998  nuclear envelope organization
GO:0007097  nuclear migration
GO:0031022  nuclear migration along microfilament
GO:0030335  positive regulation of cell migration
GO:0034504  protein localization in nucleus

Cellular Component

GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0031527  filopodium membrane
GO:0005925  focal adhesion
GO:0016021  integral to membrane
GO:0031258  lamellipodium membrane
GO:0044429  mitochondrial part
GO:0005635  nuclear envelope
GO:0031981  nuclear lumen
GO:0031965  nuclear membrane
GO:0005640  nuclear outer membrane
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0016529  sarcoplasmic reticulum
GO:0033017  sarcoplasmic reticulum membrane
GO:0034993  SUN-KASH complex
GO:0030018  Z disc

Molecular Function

GO:0003779  actin binding
GO:0005515  protein binding