phospholipase C, beta 1 (phosphoinositide-specific)

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Synonym

KIAA0581, FLJ45792, Phospholipase C-beta-1, PLC-beta-1, PLC-154, PLCB1, PLC-I

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:115 cerebellum:25.20 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:92 spine:112.30 retina:237.30 eye:76.40 artery/aorta:- vein:- lymphnode:- peripheral blood:36.40 spleen:18.90 thymus:51.50 bone marrow:39.40 adipose:40.30 bone:- skin:86.40
GeneChip cerebrum:8.27 cerebellum:5.95 brain stem:7.34 corpus callosum/glia:5.90 pineal gland:- peripheral nerve:6.49 spine:6.70 retina:- eye:- artery/aorta:5.46 vein:5.22 lymphnode:4.58 peripheral blood:- spleen:4.93 thymus:5.13 bone marrow:4.32 adipose:5.88 bone:- skin:5.25
CAGE cerebrum:4.50 cerebellum:- brain stem:3.18 corpus callosum/glia:2.89 pineal gland:3.69 peripheral nerve:- spine:3.04 retina:- eye:- artery/aorta:2.65 vein:3.16 lymphnode:1.90 peripheral blood:- spleen:2.75 thymus:3.16 bone marrow:- adipose:2.95 bone:- skin:-
RNA-seq cerebrum:3.75 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.39 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.60 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:98.40 prostate:157.70 ovary:37.30 testis:47.60 heart:38.30 muscle:20.10 esophagus:- stomach:21.20 intestine:32.40 colon:152.60     liver/hepato:147.80        lung:14.70    bladder:- kidney:83.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:88.90 breast:148.70 salivary:-
GeneChip uterus:6.66 placenta:5.97 prostate:7.32 ovary:5.42 testis:3.87 heart:5.86 muscle:6.55 esophagus:4.91 stomach:5.92 intestine:6.06 colon:5.07 liver/hepato:4.97 lung:5.23 bladder:- kidney:6.02 pituitary:5.33 thyroid/parathyroid:4.85 adrenal gland:6.11 pancreas:5.89 breast:5.86 salivary:7.75
CAGE uterus:3.81 placenta:2.20 prostate:3.60 ovary:3.09 testis:2.15 heart:3.32 muscle:2.74 esophagus:3.41 stomach:- intestine:2.47 colon:3.27     liver/hepato:2.19    lung:2.72 bladder:3.97 kidney:3.16 pituitary:3.49 thyroid/parathyroid:1.34 adrenal gland:- pancreas:3.16 breast:3.09 salivary:4.35
RNA-seq uterus:- placenta:- prostate:2.56 ovary:1.54 testis:1.71 heart:0.34 muscle:0.00 esophagus:- stomach:- intestine:- colon:2.39     liver/hepato:0.29        lung:2.20    bladder:- kidney:2.02 pituitary:- thyroid/parathyroid:1.18 adrenal gland:1.58 pancreas:- breast:1.30 salivary:-

Gene Information

IDs

Refseq ID NM_182734
Gene ID 23236
Unigene ID Hs.431173
Probe set ID 213222_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000182621
GTEx ID ENSG00000182621

Orthologous Gene

Mouse[5]  NM_001145830, NM_019677
Rat[1]  NM_001077641, NM_019677

Chromosomal Region

20p12.3  [8,112,824  -  8,949,003]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein

Link to Pubmed  (Pubmed ID)

1322796
1979339
2841328
7589147
8872139
8878798
8889548
9198220
9278385
9500449
9628581
9651375
9730685
10501179
10760467
10843712
10980202
11118617
11148035
11278470
11287604
11481231
11743656
11753430
11780052
11880496
11941371
12168954
12193606
12213492
12477932
12482669
12799190
12821674
14702039
15085153
15489334
15611108
15623527
15782111
16136505
16860758
16916647
17041247
17335878
17363325
17393430
17620288
18203956
18632858
18649358
18692062
18957514
19114693
19199708
19240061
19491339
19519170
19729020
19734545
20056178
20125193
20171262
20336759
20379614
20936779
21091263
21139048
21338571
21663700
22076473
22286107
22459146
22507702
22664479
22690784
22889834
22939629
23006664
23058275
23263487
23333304
23518928
23555755
23656785
23659438
23916604
24035496
24338081

Gene Ontology  (GO ID)

Biological Process

GO:0060466  activation of meiosis involved in egg activation
GO:0021987  cerebral cortex development
GO:0045444  fat cell differentiation
GO:0000086  G2/M transition of mitotic cell cycle
GO:0007215  glutamate signaling pathway
GO:0043647  inositol phosphate metabolic process
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0070498  interleukin-1-mediated signaling pathway
GO:0016042  lipid catabolic process
GO:0007613  memory
GO:0007213  muscarinic acetylcholine receptor signaling pathway
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0046488  phosphatidylinositol metabolic process
GO:0048639  positive regulation of developmental growth
GO:0040019  positive regulation of embryonic development
GO:0043547  positive regulation of GTPase activity
GO:0032735  positive regulation of interleukin-12 production
GO:0046330  positive regulation of JNK cascade
GO:0045663  positive regulation of myoblast differentiation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0008277  regulation of G-protein coupled receptor protein signaling pathway
GO:0007165  signal transduction
GO:0007268  synaptic transmission

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0000790  nuclear chromatin
GO:0031965  nuclear membrane
GO:0016607  nuclear speck
GO:0005634  nucleus

Molecular Function

GO:0005509  calcium ion binding
GO:0005516  calmodulin binding
GO:0019899  enzyme binding
GO:0005096  GTPase activator activity
GO:0005521  lamin binding
GO:0005546  phosphatidylinositol-4,5-bisphosphate binding
GO:0004435  phosphoinositide phospholipase C activity
GO:0042803  protein homodimerization activity
GO:0004871  signal transducer activity