neural precursor cell expressed, developmentally down-regulated 4-like

jump to detail

Synonym

FLJ33870, NEDD4L, KIAA0439, NEDD4.2, Nedd4-2, E3 ubiquitin-protein ligase NEDD4-like protein, NEDL3, RSP5, hNedd4-2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:94.80

cerebellum:125.90

brain stem:-

corpus callosum/glia:58.30

pineal gland:-

peripheral nerve:-

spine:-

retina:355.90

eye:176.30

artery/aorta:-

vein:66.60

lymphnode:30.30

peripheral blood:18.20

spleen:18.90

thymus:-

bone marrow:39.40

adipose:40.30

bone:-

skin:105.60

GeneChip

cerebrum:5.70

cerebellum:5.59

brain stem:5.72

corpus callosum/glia:5.07

pineal gland:-

peripheral nerve:6.50

spine:5

retina:-

eye:-

artery/aorta:5.12

vein:4.93

lymphnode:5.08

peripheral blood:-

spleen:4.86

thymus:4.64

bone marrow:5.45

adipose:5.60

bone:-

skin:5.93

CAGE

cerebrum:3.97

cerebellum:-

brain stem:2.56

corpus callosum/glia:2.41

pineal gland:3.30

peripheral nerve:-

spine:2.16

retina:-

eye:-

artery/aorta:2.46

vein:1.65

lymphnode:2.03

peripheral blood:-

spleen:1.83

thymus:1.31

bone marrow:-

adipose:1.81

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.22

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:54.60

prostate:506.90

ovary:111.80

testis:13

heart:89.40

muscle:100.50

esophagus:-

stomach:21.20

intestine:64.80

colon:178.10

liver/hepato:147.80

lung:146.60

bladder:-

kidney:187.10

pituitary:116

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:8.90

breast:176.60

salivary:328.40

GeneChip

uterus:5.01

placenta:6.08

prostate:8.62

ovary:5.16

testis:5.90

heart:5.72

muscle:6.55

esophagus:5.93

stomach:6.21

intestine:6.06

colon:6.68

liver/hepato:5.51

lung:6.93

bladder:-

kidney:7.38

pituitary:6.41

thyroid/parathyroid:5.59

adrenal gland:5.50

pancreas:6.54

breast:6.31

salivary:7.04

CAGE

uterus:2.39

placenta:3.63

prostate:4.03

ovary:1.73

testis:1.48

heart:1.89

muscle:0.96

esophagus:2.56

stomach:-

intestine:4.37

colon:4.24

liver/hepato:2.38

lung:4.61

bladder:3.66

kidney:3.81

pituitary:4.16

thyroid/parathyroid:3.01

adrenal gland:-

pancreas:4.10

breast:2.64

salivary:3.87

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.00

testis:0.06

heart:0

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.00

liver/hepato:0.18

lung:0.54

bladder:-

kidney:1.10

pituitary:-

thyroid/parathyroid:2.03

adrenal gland:0.00

pancreas:-

breast:0.00

salivary:-

IDs

Refseq ID	NM_001144967
Gene ID	23327
Unigene ID	Hs.185677
Probe set ID	212445_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000049759
GTEx ID	ENSG00000049759

Orthologous Gene

Mouse[4]	NM_001114386, NM_031881
Rat[1]	NM_001008300, NM_031881

Chromosomal Region

18q21.31 [55,711,619 - 56,068,772]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000008	C2 calcium-dependent membrane targeting
IPR008973	C2 calcium/lipid-binding domain, CaLB
IPR018029	C2 membrane targeting protein
IPR001202	WW/Rsp5/WWP

Gene Ontology (GO ID)

Biological Process

GO:0006883	cellular sodium ion homeostasis
GO:0007588	excretion
GO:0010467	gene expression
GO:0034220	ion transmembrane transport
GO:0010766	negative regulation of sodium ion transport
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0045807	positive regulation of endocytosis
GO:0010765	positive regulation of sodium ion transport
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0042176	regulation of protein catabolic process
GO:0010038	response to metal ion
GO:0009651	response to salt stress
GO:0006814	sodium ion transport
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006351	transcription, DNA-dependent
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0055085	transmembrane transport
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0019067	viral assembly, maturation, egress, and release
GO:0016032	viral reproduction
GO:0019048	virus-host interaction
GO:0030104	water homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005622	intracellular
GO:0005654	nucleoplasm
GO:0005634	nucleus

Molecular Function

GO:0005515	protein binding
GO:0019871	sodium channel inhibitor activity
GO:0017080	sodium channel regulator activity
GO:0004842	ubiquitin-protein ligase activity

neural precursor cell expressed, developmentally down-regulated 4-like

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function