dicer 1, ribonuclease type III

Synonym

Helicase with RNase motif, DICER, Endoribonuclease Dicer, DICER1, Helicase-MOI, HERNA, KIAA0928, Dicer, K12H4.8-LIKE, Dicer1, Dcr-1 homolog (Drosophila)

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:94.80

cerebellum:37.80

brain stem:-

corpus callosum/glia:29.20

pineal gland:296.70

peripheral nerve:30.70

spine:112.30

retina:118.60

eye:141

artery/aorta:-

vein:133.30

lymphnode:121.30

peripheral blood:36.40

spleen:-

thymus:90.20

bone marrow:39.40

adipose:-

bone:38.40

skin:67.20

GeneChip

cerebrum:6.96

cerebellum:6.91

brain stem:7.11

corpus callosum/glia:8.24

pineal gland:-

peripheral nerve:6.99

spine:7.59

retina:-

eye:-

artery/aorta:5.98

vein:5.91

lymphnode:6.68

peripheral blood:-

spleen:7.10

thymus:7.61

bone marrow:6.49

adipose:6.46

bone:-

skin:6.31

CAGE

cerebrum:3.85

cerebellum:-

brain stem:4.13

corpus callosum/glia:4.31

pineal gland:3.86

peripheral nerve:-

spine:4.17

retina:-

eye:-

artery/aorta:3.42

vein:3.32

lymphnode:3.56

peripheral blood:-

spleen:3.86

thymus:3.51

bone marrow:-

adipose:3.94

bone:-

skin:-

RNA-seq

cerebrum:2.58

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.21

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.23

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:54.70

placenta:61.90

prostate:56.30

ovary:149.10

testis:30.30

heart:102.20

muscle:40.20

esophagus:-

stomach:-

intestine:32.40

colon:42.40

liver/hepato:-

lung:73.30

bladder:251.20

kidney:52

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:151.10

breast:176.60

salivary:-

GeneChip

uterus:7.22

placenta:8.01

prostate:7.38

ovary:7.34

testis:5.83

heart:6.66

muscle:7.17

esophagus:7.15

stomach:6.76

intestine:6.65

colon:6.33

liver/hepato:6.57

lung:6.93

bladder:-

kidney:6.52

pituitary:6.45

thyroid/parathyroid:7.09

adrenal gland:6

pancreas:6.15

breast:6.95

salivary:6.06

CAGE

uterus:3.92

placenta:4.14

prostate:3.71

ovary:3.66

testis:3.31

heart:3.48

muscle:3.75

esophagus:3.61

stomach:-

intestine:3.71

colon:3.59

liver/hepato:3.62

lung:3.80

bladder:3.75

kidney:3.61

pituitary:4.07

thyroid/parathyroid:3.57

adrenal gland:-

pancreas:3.16

breast:3.66

salivary:3.17

RNA-seq

uterus:-

placenta:-

prostate:2.48

ovary:2.81

testis:3.04

heart:2.43

muscle:1.45

esophagus:-

stomach:-

intestine:-

colon:2.45

liver/hepato:2.11

lung:2.42

bladder:-

kidney:2.55

pituitary:-

thyroid/parathyroid:2.49

adrenal gland:2.70

pancreas:-

breast:2.76

salivary:-

IDs

Refseq ID	NM_030621
Gene ID	23405
Unigene ID	Hs.87889
Probe set ID	206061_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000100697
GTEx ID	ENSG00000100697

Orthologous Gene

Mouse[2]	NM_148948
Rat[2]	NM_148948

Chromosomal Region

14q32.13 [95,552,565 - 95,624,347]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR014001	DEAD-like helicase, N-terminal
IPR001159	Double-stranded RNA binding
IPR014720	Double-stranded RNA-binding-like
IPR014021	Helicase, superfamily 1/2, ATP-binding domain

Gene Ontology (GO ID)

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptosis
GO:0048754	branching morphogenesis of a tube
GO:0055013	cardiac muscle cell development
GO:0021987	cerebral cortex development
GO:0051607	defense response to virus
GO:0035116	embryonic hindlimb morphogenesis
GO:0010467	gene expression
GO:0071335	hair follicle cell proliferation
GO:0031069	hair follicle morphogenesis
GO:0060119	inner ear receptor cell development
GO:0060576	intestinal epithelial cell development
GO:0030324	lung development
GO:0035264	multicellular organism growth
GO:0032290	myelin formation in the peripheral nervous system
GO:0043066	negative regulation of apoptosis
GO:0010626	negative regulation of Schwann cell proliferation
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0021675	nerve development
GO:0048812	neuron projection morphogenesis
GO:0021889	olfactory bulb interneuron differentiation
GO:0031643	positive regulation of myelination
GO:0014040	positive regulation of Schwann cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0009791	post-embryonic development
GO:0031054	pre-microRNA processing
GO:0035196	production of miRNAs involved in gene silencing by miRNA
GO:0030422	production of siRNA involved in RNA interference
GO:0051726	regulation of cell cycle
GO:0070173	regulation of enamel mineralization
GO:0045664	regulation of neuron differentiation
GO:0048713	regulation of oligodendrocyte differentiation
GO:0045069	regulation of viral genome replication
GO:0021522	spinal cord motor neuron differentiation
GO:0051225	spindle assembly
GO:0048536	spleen development
GO:0019827	stem cell maintenance
GO:0030423	targeting of mRNA for destruction involved in RNA interference
GO:0010070	zygote asymmetric cell division

Cellular Component

GO:0005829	cytosol
GO:0016442	RNA-induced silencing complex

Molecular Function

GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0003725	double-stranded RNA binding
GO:0046872	metal ion binding
GO:0035198	miRNA binding
GO:0005515	protein binding
GO:0004525	ribonuclease III activity

dicer 1, ribonuclease type III

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function