solute carrier family 7 (cationic amino acid transporter, y+ system), member 8

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Synonym

SLC7A8, L-type amino acid transporter 2, LPI-PC1, hLAT2, LAT2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:7.48 cerebellum:7.44 brain stem:7.54 corpus callosum/glia:6.93 pineal gland:- peripheral nerve:7.18 spine:7.11 retina:- eye:- artery/aorta:7.65 vein:7.19 lymphnode:7.47 peripheral blood:- spleen:7.37 thymus:6.71 bone marrow:7.36 adipose:7.63 bone:- skin:7.77
CAGE cerebrum:3.45 cerebellum:- brain stem:2.64 corpus callosum/glia:2.85 pineal gland:4.35 peripheral nerve:- spine:2.44 retina:- eye:- artery/aorta:3.41 vein:3.05 lymphnode:3.35 peripheral blood:- spleen:4.01 thymus:1.64 bone marrow:- adipose:4.06 bone:- skin:-
RNA-seq cerebrum:2.67 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.98 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.83 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.66 placenta:8.49 prostate:8.52 ovary:7.72 testis:7.96 heart:7.20 muscle:7.29 esophagus:7.74 stomach:8.09 intestine:7.71 colon:7.31 liver/hepato:7.37 lung:7.41 bladder:- kidney:9.68 pituitary:8.13 thyroid/parathyroid:7.99 adrenal gland:7.64 pancreas:8.18 breast:7.75 salivary:7.64
CAGE uterus:4.07 placenta:4.75 prostate:3.75 ovary:4.40 testis:4.13 heart:2.93 muscle:4.42 esophagus:3.77 stomach:- intestine:3.83 colon:3.07     liver/hepato:2.69    lung:3.62 bladder:3.61 kidney:4.90 pituitary:4.26 thyroid/parathyroid:4.17 adrenal gland:- pancreas:3.69 breast:3.54 salivary:3.79
RNA-seq uterus:- placenta:- prostate:2.46 ovary:4.20 testis:2.82 heart:1.79 muscle:3.08 esophagus:- stomach:- intestine:- colon:1.68     liver/hepato:1.82        lung:2.07    bladder:- kidney:4.43 pituitary:- thyroid/parathyroid:6.19 adrenal gland:1.45 pancreas:- breast:1.11 salivary:-

Gene Information

IDs

Refseq ID NM_012244
Gene ID 23428
Unigene ID -
Probe set ID 202752_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000092068
GTEx ID ENSG00000092068

Orthologous Gene

Mouse[1]  NM_016972
Rat[1]  NM_053442

Chromosomal Region

14q11.2  [23,594,504  -  23,652,883]

Gene Family (Interpro ID)

IPR002293  Amino acid/polyamine transporter I
IPR004760  L-type amino acid transporter

Link to Pubmed  (Pubmed ID)

8125298
10080183
10391915
10574970
10610726
11311135
12117417
12477932
12716892
14702039
15489334
15769744
15901826
15918515
17558306
18195088
19851296
19913121
20198315
20379614
20628086
21486766
21906983

Gene Ontology  (GO ID)

Biological Process

GO:0006865  amino acid transport
GO:0007596  blood coagulation
GO:0006520  cellular amino acid metabolic process
GO:0006811  ion transport
GO:0050900  leukocyte migration
GO:0055065  metal ion homeostasis
GO:0015804  neutral amino acid transport
GO:0015695  organic cation transport
GO:0009636  response to toxin
GO:0055085  transmembrane transport
GO:0006810  transport

Cellular Component

GO:0016323  basolateral plasma membrane
GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0015171  amino acid transmembrane transporter activity
GO:0015179  L-amino acid transmembrane transporter activity
GO:0015175  neutral amino acid transmembrane transporter activity
GO:0015101  organic cation transmembrane transporter activity
GO:0042605  peptide antigen binding
GO:0005515  protein binding
GO:0019534  toxin transporter activity