cardiotrophin-like cytokine factor 1

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Synonym

Novel neurotrophin-1, NNT1, CLC, B cell-stimulating factor 3, CRLF1 associated cytokine-like factor 1, BSF3, Cardiotrophin-like cytokine factor 1 precursor, CISS2, cardiotrophin-like cytokine factor 1, CLCF1, NR6, BSF-3, NNT-1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:9.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:118.60 eye:17.60 artery/aorta:- vein:- lymphnode:60.70 peripheral blood:18.20 spleen:94.50 thymus:- bone marrow:- adipose:- bone:25.60 skin:14.40
GeneChip cerebrum:6.38 cerebellum:6.66 brain stem:6.37 corpus callosum/glia:6.39 pineal gland:- peripheral nerve:6.16 spine:6.25 retina:- eye:- artery/aorta:6.48 vein:6.83 lymphnode:6.48 peripheral blood:- spleen:6.44 thymus:6.08 bone marrow:6.38 adipose:6.50 bone:- skin:6.22
CAGE cerebrum:0.06 cerebellum:- brain stem:0.03 corpus callosum/glia:0.18 pineal gland:0 peripheral nerve:- spine:0.22 retina:- eye:- artery/aorta:0.34 vein:0.18 lymphnode:0.17 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0.14 bone:- skin:-
RNA-seq cerebrum:0.29 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.85 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.63 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:18.20 prostate:- ovary:37.30 testis:17.30 heart:- muscle:- esophagus:- stomach:42.50 intestine:- colon:17     liver/hepato:10.60        lung:34.20    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:6.56 placenta:6.27 prostate:6.05 ovary:6.58 testis:6.01 heart:6.41 muscle:6.49 esophagus:6.35 stomach:6.40 intestine:6.37 colon:6.44 liver/hepato:6.32 lung:6.38 bladder:- kidney:6.43 pituitary:6.43 thyroid/parathyroid:6.32 adrenal gland:6.38 pancreas:6.78 breast:6.44 salivary:6.27
CAGE uterus:0.59 placenta:0.37 prostate:0.21 ovary:0.07 testis:0.37 heart:0.30 muscle:0.17 esophagus:0.26 stomach:- intestine:0.07 colon:0.04     liver/hepato:0    lung:0.61 bladder:0.46 kidney:0.88 pituitary:0.58 thyroid/parathyroid:0.41 adrenal gland:- pancreas:0 breast:0.55 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0.84 ovary:0.93 testis:0.49 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.13     liver/hepato:0.00        lung:1.25    bladder:- kidney:0.95 pituitary:- thyroid/parathyroid:0.77 adrenal gland:0.66 pancreas:- breast:0.66 salivary:-

Gene Information

IDs

Refseq ID NM_013246
Gene ID 23529
Unigene ID Hs.502977
Probe set ID 219500_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000175505
GTEx ID ENSG00000175505

Orthologous Gene

Mouse[3]  NM_019952
Rat[1]  NM_207615

Chromosomal Region

11q13.2  [67,131,639  -  67,141,648]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

10448081
10500198
10966616
11285233
11294841
12477932
12639901
14632778
15272019
15489334
16341674
16782820
17436251
18728012
21097510
21370513

Gene Ontology  (GO ID)

Biological Process

GO:0030183  B cell differentiation
GO:0007166  cell surface receptor linked signal transduction
GO:0019221  cytokine-mediated signaling pathway
GO:0007259  JAK-STAT cascade
GO:0043524  negative regulation of neuron apoptosis
GO:0048711  positive regulation of astrocyte differentiation
GO:0030890  positive regulation of B cell proliferation
GO:0008284  positive regulation of cell proliferation
GO:0002639  positive regulation of immunoglobulin production
GO:0048295  positive regulation of isotype switching to IgE isotypes
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein

Cellular Component

GO:0005576  extracellular region

Molecular Function

GO:0005127  ciliary neurotrophic factor receptor binding
GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0005102  receptor binding