mitogen-activated protein kinase 8 interacting protein 2

 jump to detail

Synonym

C-jun-amino-terminal kinase-interacting protein 2, JIP2, MAPK8IP2, IB-2, JNK-interacting protein 2, JIP-2, JNK MAP kinase scaffold protein 2, PRKM8IPL, IB2, Islet-brain-2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:72.30 cerebellum:50.40 brain stem:- corpus callosum/glia:- pineal gland:296.70 peripheral nerve:30.70 spine:- retina:118.60 eye:64.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.67 cerebellum:6.99 brain stem:6.73 corpus callosum/glia:5.81 pineal gland:- peripheral nerve:6.52 spine:6.01 retina:- eye:- artery/aorta:5.55 vein:5.74 lymphnode:5.36 peripheral blood:- spleen:5.17 thymus:5.36 bone marrow:5.96 adipose:5.67 bone:- skin:5.68
CAGE cerebrum:4.52 cerebellum:- brain stem:3.81 corpus callosum/glia:3.00 pineal gland:3.57 peripheral nerve:- spine:3.11 retina:- eye:- artery/aorta:1.03 vein:0.96 lymphnode:0.35 peripheral blood:- spleen:0.71 thymus:0.37 bone marrow:- adipose:0.36 bone:- skin:-
RNA-seq cerebrum:1.56 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.05 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.38 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:14.60 prostate:- ovary:- testis:17.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:17     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:44.50 breast:18.60 salivary:-
GeneChip uterus:5.36 placenta:5.41 prostate:5.29 ovary:5.44 testis:5.78 heart:5.52 muscle:5.77 esophagus:5.45 stomach:5.38 intestine:5.44 colon:5.65 liver/hepato:5.53 lung:5.62 bladder:- kidney:5.42 pituitary:6.44 thyroid/parathyroid:5.37 adrenal gland:5.51 pancreas:6.36 breast:5.46 salivary:5.82
CAGE uterus:1.00 placenta:1.05 prostate:1.03 ovary:2.30 testis:2.40 heart:0.22 muscle:0.25 esophagus:0.68 stomach:- intestine:0.69 colon:1.12     liver/hepato:0.55    lung:0.96 bladder:0.33 kidney:0.74 pituitary:3.57 thyroid/parathyroid:0.98 adrenal gland:- pancreas:0 breast:0.90 salivary:2.63
RNA-seq uterus:- placenta:- prostate:0.00 ovary:1.06 testis:1.06 heart:0.05 muscle:0.13 esophagus:- stomach:- intestine:- colon:0.27     liver/hepato:0.01        lung:0.35    bladder:- kidney:0.59 pituitary:- thyroid/parathyroid:0.42 adrenal gland:0.00 pancreas:- breast:0.01 salivary:-

Gene Information

IDs

Refseq ID NM_016431
Gene ID 23542
Unigene ID Hs.558180
Probe set ID 208603_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000008735
GTEx ID ENSG00000008735

Orthologous Gene

Mouse[2]  NM_021921
Rat[2]  NM_021921

Chromosomal Region

22q13.33  [51,039,114  -  51,049,979]

Gene Family (Interpro ID)

IPR006020  Phosphotyrosine interaction domain
IPR011993  Pleckstrin homology-type

Link to Pubmed  (Pubmed ID)

8619474
8889548
9110174
10490659
10591208
10629060
10756100
10827173
11378392
12023290
12024021
12244047
12477932
12508107
12524447
12529303
12893827
15489334
16169070
16273093
16301330
16456539
18286207
20173330
21048139
21890473
21900206
23225497
24551779
24561123

Gene Ontology  (GO ID)

Biological Process

GO:0001662  behavioral fear response
GO:0048813  dendrite morphogenesis
GO:0000165  MAPKKK cascade
GO:0046958  nonassociative learning
GO:0045860  positive regulation of protein kinase activity
GO:0060079  regulation of excitatory postsynaptic membrane potential
GO:0046328  regulation of JNK cascade
GO:0010469  regulation of receptor activity
GO:0051966  regulation of synaptic transmission, glutamatergic
GO:0007172  signal complex assembly
GO:0035176  social behavior

Cellular Component

GO:0005737  cytoplasm

Molecular Function

GO:0001540  beta-amyloid binding
GO:0019894  kinesin binding
GO:0005078  MAP-kinase scaffold activity
GO:0030295  protein kinase activator activity
GO:0019901  protein kinase binding
GO:0005198  structural molecule activity