SH3-domain binding protein 4

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Synonym

BOG25, SH3-domain binding protein 4, SH3BP4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:30.80 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:30.70 spine:112.30 retina:- eye:64.60 artery/aorta:179.90 vein:199.90 lymphnode:- peripheral blood:- spleen:18.90 thymus:- bone marrow:- adipose:- bone:38.40 skin:115.20
GeneChip cerebrum:6.95 cerebellum:4.69 brain stem:7.21 corpus callosum/glia:7.91 pineal gland:- peripheral nerve:7.67 spine:7.06 retina:- eye:- artery/aorta:7.05 vein:6.38 lymphnode:5.38 peripheral blood:- spleen:6.24 thymus:5.16 bone marrow:4.63 adipose:6.86 bone:- skin:7.28
CAGE cerebrum:2.74 cerebellum:- brain stem:3.26 corpus callosum/glia:3.72 pineal gland:1.26 peripheral nerve:- spine:2.91 retina:- eye:- artery/aorta:3.21 vein:2.22 lymphnode:1.83 peripheral blood:- spleen:2.26 thymus:1.60 bone marrow:- adipose:2.66 bone:- skin:-
RNA-seq cerebrum:2.73 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.96 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.06 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:21.90 prostate:67.60 ovary:- testis:34.60 heart:102.20 muscle:- esophagus:- stomach:- intestine:- colon:76.30     liver/hepato:21.10        lung:78.20    bladder:- kidney:135.20 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:44.50 breast:167.30 salivary:-
GeneChip uterus:6.95 placenta:7.43 prostate:8.51 ovary:8.05 testis:7.40 heart:6.61 muscle:5.63 esophagus:6.61 stomach:7.75 intestine:7.78 colon:7.47 liver/hepato:7.57 lung:7.42 bladder:- kidney:8.23 pituitary:5.58 thyroid/parathyroid:6.79 adrenal gland:6.94 pancreas:8.33 breast:7.86 salivary:9.70
CAGE uterus:2.59 placenta:3.19 prostate:3.07 ovary:3.14 testis:3.09 heart:2.47 muscle:1.69 esophagus:2.51 stomach:- intestine:2.72 colon:3.15     liver/hepato:3.47    lung:2.64 bladder:2.45 kidney:3.34 pituitary:1.65 thyroid/parathyroid:2.74 adrenal gland:- pancreas:4.03 breast:3.02 salivary:4.74
RNA-seq uterus:- placenta:- prostate:2.65 ovary:3.94 testis:2.99 heart:1.82 muscle:1.53 esophagus:- stomach:- intestine:- colon:2.64     liver/hepato:3.21        lung:2.63    bladder:- kidney:3.57 pituitary:- thyroid/parathyroid:3.74 adrenal gland:2.28 pancreas:- breast:2.91 salivary:-

Gene Information

IDs

Refseq ID NM_014521
Gene ID 23677
Unigene ID Hs.516777
Probe set ID 222258_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000130147
GTEx ID ENSG00000130147

Orthologous Gene

Mouse[1]  NM_133816
Rat[1]  NM_022693

Chromosomal Region

2q37.2  [235,860,617  -  235,964,358]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7568168
9303539
10644451
12477932
15324660
15489334
15616480
15778465
15815621
16325581
16964243
17353931
18654987
19056867
20379614
20936779
21139048
21150319
21546767
21890473
21906983
22419666
22575674
23000965

Gene Ontology  (GO ID)

Biological Process

GO:0043090  amino acid import
GO:0008150  biological_process
GO:0071230  cellular response to amino acid stimulus
GO:0006897  endocytosis
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0034260  negative regulation of GTPase activity
GO:0032007  negative regulation of TOR signaling pathway
GO:0010508  positive regulation of autophagy
GO:0050790  regulation of catalytic activity

Cellular Component

GO:0005575  cellular_component
GO:0030136  clathrin-coated vesicle
GO:0005905  coated pit
GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0005092  GDP-dissociation inhibitor activity
GO:0003674  molecular_function
GO:0005515  protein binding
GO:0017016  Ras GTPase binding