arachidonate 12-lipoxygenase

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Synonym

12-LOX, Arachidonate 12-lipoxygenase, 12S-type, arachidonate 12-lipoxygenase, LOG12, ALOX12, Platelet-type lipoxygenase 12

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.52 cerebellum:4.49 brain stem:4.61 corpus callosum/glia:4.36 pineal gland:- peripheral nerve:4.40 spine:4.51 retina:- eye:- artery/aorta:4.49 vein:4.70 lymphnode:4.68 peripheral blood:- spleen:4.54 thymus:4.38 bone marrow:5.37 adipose:4.61 bone:- skin:5.85
CAGE cerebrum:0.03 cerebellum:- brain stem:0.07 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.34 vein:0 lymphnode:1.01 peripheral blood:- spleen:0.51 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.26 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.32 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:4.61 placenta:4.35 prostate:4.24 ovary:4.47 testis:4.45 heart:4.55 muscle:4.70 esophagus:8.64 stomach:4.38 intestine:4.61 colon:4.67 liver/hepato:4.50 lung:4.31 bladder:- kidney:4.66 pituitary:4.58 thyroid/parathyroid:4.29 adrenal gland:4.38 pancreas:4.49 breast:4.67 salivary:4.48
CAGE uterus:2.16 placenta:0.24 prostate:0 ovary:0 testis:0.16 heart:0.10 muscle:0 esophagus:3.06 stomach:- intestine:0 colon:0.04     liver/hepato:0    lung:0.10 bladder:0.09 kidney:0 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.21 ovary:0.23 testis:0.31 heart:0.06 muscle:0.01 esophagus:- stomach:- intestine:- colon:0.25     liver/hepato:0.06        lung:1.07    bladder:- kidney:0.26 pituitary:- thyroid/parathyroid:0.26 adrenal gland:0.46 pancreas:- breast:0.23 salivary:-

Gene Information

IDs

Refseq ID NM_000697
Gene ID 239
Unigene ID -
Probe set ID 207206_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000108839
GTEx ID ENSG00000108839

Orthologous Gene

Mouse[2]  NM_007440
Rat[1]  NM_001105798

Chromosomal Region

17p13.1  [6,899,384  -  6,914,055]

Gene Family (Interpro ID)

IPR008976  Lipase/lipooxygenase, PLAT/LH2
IPR000907  Lipoxygenase
IPR001024  Lipoxygenase, LH2
IPR001885  Lipoxygenase, mammalian

Link to Pubmed  (Pubmed ID)

1447217
1570320
1851637
2217179
2244907
2377602
3406043
3926763
7868854
8250832
8304420
8319693
8641843
8912711
9082968
9751607
10446449
10727209
10760478
11914583
12394183
12477932
12538614
12664313
12664573
12664578
12731864
12858336
12907138
14532840
14669797
14767568
15010818
15105833
15107407
15111312
15142951
15305153
15308583
15474031
15489334
15729574
15797645
16118214
16482570
16514435
16598376
16638750
16788089
17045234
17151091
17192687
17236225
17379189
17460548
17520163
17893696
18086569
18187376
18504448
18547056
18640486
18676680
18755188
18992148
19046748
19056867
19170196
19328558
19423540
19469483
19625176
19663136
19692168
19885615
19913121
19948975
20061896
20089617
20181616
20382140
20406964
20431935
20438785
20453000
20570249
20592751
20626912
20628086
20653566
20697415
21085606
21094135
21104233
21127289
21225230
21945939
22089472
22237009
22275252
22323304
22384268
22668814
22825379
22864639
22895552
22924777
22980500
23079635
23526143
23528921
23578768
23715757
23784669
23828562

Gene Ontology  (GO ID)

Biological Process

GO:0007568  aging
GO:0019369  arachidonic acid metabolic process
GO:0006928  cellular component movement
GO:0071396  cellular response to lipid
GO:0019395  fatty acid oxidation
GO:0051122  hepoxilin biosynthetic process
GO:0051121  hepoxilin metabolic process
GO:0019370  leukotriene biosynthetic process
GO:0043651  linoleic acid metabolic process
GO:0019372  lipoxygenase pathway
GO:0043066  negative regulation of apoptosis
GO:0010656  negative regulation of muscle cell apoptosis
GO:0045766  positive regulation of angiogenesis
GO:0043065  positive regulation of apoptosis
GO:0043280  positive regulation of caspase activity
GO:0045785  positive regulation of cell adhesion
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0045603  positive regulation of endothelial cell differentiation
GO:0010595  positive regulation of endothelial cell migration
GO:0010628  positive regulation of gene expression
GO:0051901  positive regulation of mitochondrial depolarization
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045909  positive regulation of vasodilation
GO:0042554  superoxide anion generation

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016020  membrane
GO:0042383  sarcolemma

Molecular Function

GO:0004052  arachidonate 12-lipoxygenase activity
GO:0051120  hepoxilin A3 synthase activity
GO:0047977  hepoxilin-epoxide hydrolase activity
GO:0005506  iron ion binding
GO:0016165  lipoxygenase activity
GO:0016702  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0005515  protein binding