c-abl oncogene 1, receptor tyrosine kinase

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Synonym

Abelson murine leukemia viral oncogene homolog 1, ABL1, v-abl, JTK7, Proto-oncogene tyrosine-protein kinase ABL1, c-ABL, ABL

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:69.90 cerebellum:50.40 brain stem:- corpus callosum/glia:87.50 pineal gland:148.30 peripheral nerve:30.70 spine:112.30 retina:- eye:99.90 artery/aorta:30 vein:133.30 lymphnode:60.70 peripheral blood:18.20 spleen:94.50 thymus:38.70 bone marrow:118.10 adipose:40.30 bone:12.80 skin:240
GeneChip cerebrum:7.39 cerebellum:6.68 brain stem:7.49 corpus callosum/glia:8.41 pineal gland:- peripheral nerve:7.38 spine:7.96 retina:- eye:- artery/aorta:8.32 vein:8.26 lymphnode:7.30 peripheral blood:- spleen:7.53 thymus:7.42 bone marrow:6.47 adipose:8.08 bone:- skin:7.72
CAGE cerebrum:2.24 cerebellum:- brain stem:2.79 corpus callosum/glia:3.24 pineal gland:2.36 peripheral nerve:- spine:2.58 retina:- eye:- artery/aorta:3.47 vein:2.63 lymphnode:2.08 peripheral blood:- spleen:1.89 thymus:1.56 bone marrow:- adipose:2.92 bone:- skin:-
RNA-seq cerebrum:1.94 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.94 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.88 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:36.40 prostate:157.70 ovary:298.10 testis:64.90 heart:89.40 muscle:- esophagus:- stomach:85 intestine:- colon:161.10     liver/hepato:42.20        lung:48.90    bladder:- kidney:72.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:74.30 salivary:-
GeneChip uterus:8.64 placenta:7.02 prostate:7.94 ovary:8.14 testis:7.28 heart:7.59 muscle:7 esophagus:7.68 stomach:8.11 intestine:7.88 colon:8.56 liver/hepato:6.87 lung:7.65 bladder:- kidney:7.73 pituitary:7.61 thyroid/parathyroid:8.35 adrenal gland:7.57 pancreas:6.62 breast:8.15 salivary:7.79
CAGE uterus:3.22 placenta:1.96 prostate:3.18 ovary:3.00 testis:1.90 heart:2.74 muscle:2.05 esophagus:2.57 stomach:- intestine:2.57 colon:3.03     liver/hepato:0.84    lung:2.31 bladder:3.43 kidney:1.81 pituitary:2.36 thyroid/parathyroid:2.68 adrenal gland:- pancreas:1.74 breast:2.91 salivary:2.12
RNA-seq uterus:- placenta:- prostate:2.03 ovary:2.93 testis:3.01 heart:2.08 muscle:2.65 esophagus:- stomach:- intestine:- colon:2.32     liver/hepato:1.39        lung:2.54    bladder:- kidney:1.86 pituitary:- thyroid/parathyroid:2.61 adrenal gland:2.87 pancreas:- breast:2.51 salivary:-

IDs

Refseq ID NM_007313
Gene ID 25
Unigene ID Hs.431048
Probe set ID 202123_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000097007
GTEx ID ENSG00000097007

Orthologous Gene

Mouse[4]  NM_001112703, NM_009594
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1281542
1379745
1383690
1505033
1538749
1571536
1712671
1857987
1868241
2163052
2183353
2193202
2542016
2678002
2687768
2825022
2989692
2989703
3021337
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3313010
3471171
4062888
6191223
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6302194
6316147
6319012
6323103
7493940
7512963
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7545908
7565761
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7780740
7828850
7892170
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7968380
8112292
8114715
8194526
8242749
8294442
8438166
8453102
8524328
8590002
8626527
8626543
8629002
8630736
8668148
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8879209
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9006901
9008161
9010225
9037071
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9144171
9168116
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9195915
9211900
9312071
9315092
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9356459
9407116
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9480911
9516488
9583676
9593709
9603926
9632734
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9747873
9774693
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9820532
9822717
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9949177
10187839
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10212258
10372803
10391249
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10455176
10488096
10567556
10571082
10574931
10608806
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10679771
10688886
10708759
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11431473
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12781448
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15696159
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17943163
17956664
17972958
18029348
18036399
18059481
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18082628
18089786
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18161990
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18235045
18262060
18280240
18287094
18305217
18305550
18339898
18362889
18369471
18391983
18401414
18406870
18413724
18427551
18480060
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18490454
18538733
18546844
18559503
18603549
18614052
18619508
18687796
18704194
18765637
18771174
18775312
18784740
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18809728
18827185
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19001122
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19020542
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19061839
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19108887
19124506
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19156526
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19531213
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20007699
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20073070
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20082857
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20152788
20201926
20234815
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20425353
20452982
20453000
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20512393
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20581864
20585028
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20629032
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20717963
20724541
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20863169
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21071472
21072043
21129254
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21591355
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22014333
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22952603
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23959873
23974192
23980151
24041959
24112389
24140708
24262285
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24317448
24456693
24550512
24779036

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0006914  autophagy
GO:0007411  axon guidance
GO:0007596  blood coagulation
GO:0007155  cell adhesion
GO:0006975  DNA damage induced protein phosphorylation
GO:0042770  DNA damage response, signal transduction
GO:0008630  DNA damage response, signal transduction resulting in induction of apoptosis
GO:0045087  innate immune response
GO:0006298  mismatch repair
GO:0042692  muscle cell differentiation
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0051149  positive regulation of muscle cell differentiation
GO:0051353  positive regulation of oxidoreductase activity
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0006464  protein modification process
GO:0010506  regulation of autophagy
GO:0030155  regulation of cell adhesion
GO:0051726  regulation of cell cycle
GO:0030100  regulation of endocytosis
GO:0000115  regulation of transcription involved in S-phase of mitotic cell cycle
GO:0006355  regulation of transcription, DNA-dependent
GO:0006974  response to DNA damage stimulus

Cellular Component

GO:0015629  actin cytoskeleton
GO:0031252  cell leading edge
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005739  mitochondrion
GO:0031965  nuclear membrane
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0003785  actin monomer binding
GO:0005524  ATP binding
GO:0003677  DNA binding
GO:0000287  magnesium ion binding
GO:0030145  manganese ion binding
GO:0051019  mitogen-activated protein kinase binding
GO:0004515  nicotinate-nucleotide adenylyltransferase activity
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0070064  proline-rich region binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0004713  protein tyrosine kinase activity
GO:0017124  SH3 domain binding
GO:0019905  syntaxin binding