nephronectin

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Synonym

nephronectin, EGFL6L, POEM, NPNT

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:16.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:398.70 spine:- retina:- eye:23.50 artery/aorta:179.90 vein:- lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:- adipose:- bone:- skin:163.20
GeneChip nodata
CAGE cerebrum:1.34 cerebellum:- brain stem:1.81 corpus callosum/glia:1.49 pineal gland:1.44 peripheral nerve:- spine:0.90 retina:- eye:- artery/aorta:4.86 vein:2.47 lymphnode:1.02 peripheral blood:- spleen:2.23 thymus:1.80 bone marrow:- adipose:1.93 bone:- skin:-
RNA-seq cerebrum:0.65 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.94 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.90 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:25.50 prostate:135.20 ovary:- testis:26 heart:114.90 muscle:- esophagus:- stomach:- intestine:129.60 colon:84.80     liver/hepato:10.60        lung:117.30    bladder:251.20 kidney:114.40 pituitary:232 thyroid/parathyroid:- adrenal gland:- pancreas:53.30 breast:27.90 salivary:-
GeneChip nodata
CAGE uterus:3.27 placenta:1.83 prostate:3.09 ovary:2.27 testis:1.94 heart:1.82 muscle:1.61 esophagus:2.51 stomach:- intestine:4.33 colon:3.13     liver/hepato:1.01    lung:4.43 bladder:2.16 kidney:3.52 pituitary:3.33 thyroid/parathyroid:5.47 adrenal gland:- pancreas:2.90 breast:2.59 salivary:1.67
RNA-seq uterus:- placenta:- prostate:3.06 ovary:2.15 testis:3.33 heart:1.11 muscle:0.07 esophagus:- stomach:- intestine:- colon:3.10     liver/hepato:0.67        lung:5.08    bladder:- kidney:4.67 pituitary:- thyroid/parathyroid:6.97 adrenal gland:2.40 pancreas:- breast:1.99 salivary:-

Gene Information

IDs

Refseq ID NM_001033047
Gene ID 255743
Unigene ID Hs.518921
Probe set ID -
Ensembl ID ENSG00000168743
GTEx ID ENSG00000168743

Orthologous Gene

Mouse[10]  NM_001029836, NM_033525
Rat[10]  NM_001029836, NM_033525

Chromosomal Region

4q24  [106,815,932  -  106,925,184]

Gene Family (Interpro ID)

IPR001881  EGF-like calcium-binding
IPR000742  EGF-like, type 3

Link to Pubmed  (Pubmed ID)

8889548
11470814
11470831
12477932
12975309
15754038
19199708
19844573
20010835
20332099
22172726
23284291
23689482

Gene Ontology  (GO ID)

Biological Process

GO:0001658  branching involved in ureteric bud morphogenesis
GO:0033631  cell-cell adhesion mediated by integrin
GO:0007160  cell-matrix adhesion
GO:0071356  cellular response to tumor necrosis factor
GO:0045184  establishment of protein localization
GO:0030198  extracellular matrix organization
GO:0010694  positive regulation of alkaline phosphatase activity
GO:0010811  positive regulation of cell-substrate adhesion
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0045669  positive regulation of osteoblast differentiation
GO:0045987  positive regulation of smooth muscle contraction
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0001657  ureteric bud development

Cellular Component

GO:0034678  alpha8-beta1 integrin complex
GO:0005604  basement membrane
GO:0005576  extracellular region
GO:0005578  proteinaceous extracellular matrix
GO:0030485  smooth muscle contractile fiber

Molecular Function

GO:0005509  calcium ion binding
GO:0005178  integrin binding