mitogen-activated protein kinase kinase kinase 7 interacting protein 3

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Synonym

MGC45404, NF-kappa-B-activating protein 1, MAP3K7IP3, TAK1-binding protein 3, TAB3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:19 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:153.40 spine:112.30 retina:- eye:17.60 artery/aorta:- vein:- lymphnode:10.10 peripheral blood:18.20 spleen:- thymus:12.90 bone marrow:- adipose:- bone:- skin:19.20
GeneChip nodata
CAGE cerebrum:1.51 cerebellum:- brain stem:1.63 corpus callosum/glia:1.58 pineal gland:3.00 peripheral nerve:- spine:1.32 retina:- eye:- artery/aorta:1.94 vein:1.89 lymphnode:2.35 peripheral blood:- spleen:1.92 thymus:1.99 bone marrow:- adipose:1.79 bone:- skin:-
RNA-seq cerebrum:2.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.28 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.49 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:40.10 prostate:33.80 ovary:37.30 testis:34.60 heart:- muscle:- esophagus:- stomach:- intestine:- colon:17     liver/hepato:10.60        lung:14.70    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:18.60 salivary:-
GeneChip nodata
CAGE uterus:2.94 placenta:3.52 prostate:2.61 ovary:2.15 testis:3.18 heart:1.90 muscle:1.46 esophagus:2.46 stomach:- intestine:1.92 colon:2.00     liver/hepato:2.95    lung:2.03 bladder:1.83 kidney:2.75 pituitary:1.91 thyroid/parathyroid:1.76 adrenal gland:- pancreas:2.48 breast:1.53 salivary:2.50
RNA-seq uterus:- placenta:- prostate:2.59 ovary:3.03 testis:3.18 heart:2.38 muscle:2.22 esophagus:- stomach:- intestine:- colon:1.69     liver/hepato:3.03        lung:2.09    bladder:- kidney:2.93 pituitary:- thyroid/parathyroid:2.82 adrenal gland:2.37 pancreas:- breast:2.56 salivary:-

Gene Information

IDs

Refseq ID NM_152787
Gene ID 257397
Unigene ID Hs.188256
Probe set ID -
Ensembl ID ENSG00000157625
GTEx ID ENSG00000157625

Orthologous Gene

Mouse[1]  NM_025729
Rat[1]  NM_025729

Chromosomal Region

Xp21.2  [30,845,559  -  30,993,201]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

10066798
10882101
12477932
12609980
14633987
14670075
14702039
14743216
14766965
15276183
15327770
15489334
16189514
17158449
17384642
17449468
18021073
18345001
19232515
19521662
19820708
19927120
21139048
21512569
21512573
21572451
21575904
21866272
21903422
21976705
22081109
22158122
22660635
23286385
24434549

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0045087  innate immune response
GO:0007254  JNK cascade
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0010008  endosome membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005515  protein binding
GO:0008270  zinc ion binding