F-box and WD repeat domain containing 8

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Synonym

FBW6, FBXW6, F-box only protein 29, F-box/WD repeat protein 8, MGC33534, FBW8, FBXW8, FBX29, FBXO29, F-box and WD-40 domain protein 8

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip nodata
CAGE cerebrum:2.33 cerebellum:- brain stem:2.42 corpus callosum/glia:2.87 pineal gland:2.83 peripheral nerve:- spine:2.32 retina:- eye:- artery/aorta:2.34 vein:2.73 lymphnode:2.76 peripheral blood:- spleen:2.49 thymus:2.61 bone marrow:- adipose:2.51 bone:- skin:-
RNA-seq cerebrum:0.17 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.80 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.65 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip nodata
CAGE uterus:3.08 placenta:3.05 prostate:2.77 ovary:2.95 testis:2.70 heart:2.53 muscle:2.19 esophagus:2.35 stomach:- intestine:2.30 colon:2.59     liver/hepato:2.38    lung:2.27 bladder:2.36 kidney:2.41 pituitary:3.33 thyroid/parathyroid:2.87 adrenal gland:- pancreas:3.10 breast:2.27 salivary:3.34
RNA-seq uterus:- placenta:- prostate:0.90 ovary:0.54 testis:0.14 heart:0.47 muscle:0.41 esophagus:- stomach:- intestine:- colon:0.34     liver/hepato:0.11        lung:0.14    bladder:- kidney:0.34 pituitary:- thyroid/parathyroid:1.07 adrenal gland:0.29 pancreas:- breast:0.20 salivary:-

Gene Information

IDs

Refseq ID NM_153348
Gene ID 26259
Unigene ID -
Probe set ID -
Ensembl ID ENSG00000174989
GTEx ID ENSG00000174989

Orthologous Gene

Mouse[1]  NM_172721
Rat [0]  

Chromosomal Region

12q24.22  [117,348,761  -  117,470,180]

Gene Family (Interpro ID)

IPR001680  WD40 repeat
IPR019782  WD40 repeat 2
IPR019781  WD40 repeat, subgroup
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

10531035
10531037
12477932
12481031
14702039
15070733
15489334
16142236
17079684
17205132
17314511
17332328
17998335
18354482
18498745
18650423
19297328
20558726
20878477
21070969
21145461
21572988
21890473
21946088
22268729
22388891
22504417
22524683
23029530
23045529
24362026

Gene Ontology  (GO ID)

Biological Process

GO:0007030  Golgi organization
GO:0060716  labyrinthine layer blood vessel development
GO:0050775  positive regulation of dendrite morphogenesis
GO:0060712  spongiotrophoblast layer development

Cellular Component

GO:0031467  Cul7-RING ubiquitin ligase complex
GO:0005794  Golgi apparatus
GO:0048471  perinuclear region of cytoplasm
GO:0019005  SCF ubiquitin ligase complex

Molecular Function

GO:0005515  protein binding