growth differentiation factor 2

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Synonym

BMP-9, BMP9, growth differentiation factor 2, Bone morphogenetic protein 9, Growth/differentiation factor 2 precursor, GDF2, GDF-2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.39 cerebellum:6.50 brain stem:6.46 corpus callosum/glia:6.33 pineal gland:- peripheral nerve:5.94 spine:6.14 retina:- eye:- artery/aorta:6.28 vein:6.75 lymphnode:6.12 peripheral blood:- spleen:5.99 thymus:5.99 bone marrow:6.56 adipose:6.25 bone:- skin:6.18
CAGE cerebrum:0 cerebellum:- brain stem:0.03 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.01 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:21.10        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:6.13 placenta:6.10 prostate:5.74 ovary:6.42 testis:5.76 heart:6.66 muscle:6.85 esophagus:6.36 stomach:6.18 intestine:6.56 colon:6.53 liver/hepato:6.29 lung:6.25 bladder:- kidney:6.32 pituitary:6.20 thyroid/parathyroid:6 adrenal gland:6.35 pancreas:7.18 breast:6.10 salivary:6.48
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:2.70    lung:0 bladder:0 kidney:0 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0.02 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:2.70        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_016204
Gene ID 2658
Unigene ID Hs.279463
Probe set ID 221136_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000128802
GTEx ID ENSG00000128802

Orthologous Gene

Mouse[1]  NM_019506
Rat[1]  NM_019506

Chromosomal Region

10q11.22  [48,413,092  -  48,416,853]

Gene Family (Interpro ID)

IPR002405  Inhibin, alpha subunit
IPR015615  Transforming growth factor-beta-related

Link to Pubmed  (Pubmed ID)

10849432
10894782
11748585
12477932
15489334
15851468
16385451
17068149
17311849
17549388
18309101
18922975
18986983
19056867
19086053
19366699
19996292
20237496
20346360
20398908
20406889
20734064
21695154
21710321
21737454
22299030
22474252
22493445
22556408
22718755
22829878
22948234
23018639
23313128
23807047
23844832
23936038
23972370
24019898
24072698

Gene Ontology  (GO ID)

Biological Process

GO:0032924  activin receptor signaling pathway
GO:0048514  blood vessel morphogenesis
GO:0030509  BMP signaling pathway
GO:0051216  cartilage development
GO:0006879  cellular iron ion homeostasis
GO:0040007  growth
GO:0016525  negative regulation of angiogenesis
GO:0043537  negative regulation of blood vessel endothelial cell migration
GO:0030308  negative regulation of cell growth
GO:0008156  negative regulation of DNA replication
GO:0010596  negative regulation of endothelial cell migration
GO:0001937  negative regulation of endothelial cell proliferation
GO:0001503  ossification
GO:0001649  osteoblast differentiation
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0001569  patterning of blood vessels
GO:0045766  positive regulation of angiogenesis
GO:0030513  positive regulation of BMP signaling pathway
GO:0045603  positive regulation of endothelial cell differentiation
GO:0001938  positive regulation of endothelial cell proliferation
GO:0032757  positive regulation of interleukin-8 production
GO:0045669  positive regulation of osteoblast differentiation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0001570  vasculogenesis

Cellular Component

GO:0005615  extracellular space

Molecular Function

GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0005515  protein binding