gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)

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Synonym

Proliferation-inducing gene 2 protein, MGC126660, GREMLIN, PIG2, Down-regulated in Mos-transformed cells protein, DAND2, Cysteine knot superfamily 1, BMP antagonist 1, IHG-2, Gremlin-1 precursor, DRM, GREM1, gremlin, CKTSF1B1, Increased in high glucose protein 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.60 cerebellum:25.20 brain stem:- corpus callosum/glia:233.30 pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:569.50 vein:- lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:846.30 adipose:- bone:627 skin:542.40
GeneChip cerebrum:4.13 cerebellum:3.18 brain stem:3.72 corpus callosum/glia:4.77 pineal gland:- peripheral nerve:2.87 spine:4.12 retina:- eye:- artery/aorta:3.48 vein:5.77 lymphnode:3.95 peripheral blood:- spleen:2.84 thymus:2.70 bone marrow:2.84 adipose:4.69 bone:- skin:4.71
CAGE cerebrum:2.98 cerebellum:- brain stem:3.06 corpus callosum/glia:3.51 pineal gland:0 peripheral nerve:- spine:3.23 retina:- eye:- artery/aorta:2.90 vein:3.04 lymphnode:3.18 peripheral blood:- spleen:1.54 thymus:0.06 bone marrow:- adipose:3.12 bone:- skin:-
RNA-seq cerebrum:2.34 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.82 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.78 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:209.60 placenta:- prostate:- ovary:- testis:17.30 heart:12.80 muscle:- esophagus:- stomach:191.20 intestine:97.20 colon:110.20     liver/hepato:21.10        lung:78.20    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:18.60 salivary:-
GeneChip uterus:5.69 placenta:2.80 prostate:4.83 ovary:2.89 testis:2.84 heart:3.21 muscle:3.02 esophagus:3.92 stomach:7.51 intestine:7.24 colon:6.65 liver/hepato:2.89 lung:2.84 bladder:- kidney:2.84 pituitary:2.80 thyroid/parathyroid:3.16 adrenal gland:2.99 pancreas:3.72 breast:5.46 salivary:2.81
CAGE uterus:4.20 placenta:0.68 prostate:3.57 ovary:1.97 testis:1.24 heart:1.48 muscle:1.78 esophagus:4.33 stomach:- intestine:4.00 colon:4.10     liver/hepato:1.41    lung:1.25 bladder:4.84 kidney:1.69 pituitary:0 thyroid/parathyroid:1.83 adrenal gland:- pancreas:1.74 breast:4.09 salivary:0
RNA-seq uterus:- placenta:- prostate:2.19 ovary:0.47 testis:0.54 heart:0.04 muscle:0.00 esophagus:- stomach:- intestine:- colon:5.21     liver/hepato:0.38        lung:0.57    bladder:- kidney:0.72 pituitary:- thyroid/parathyroid:0.92 adrenal gland:3.17 pancreas:- breast:0.60 salivary:-

Gene Information

IDs

Refseq ID NM_013372
Gene ID 26585
Unigene ID Hs.40098
Probe set ID 218468_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000166923
GTEx ID ENSG00000166923

Orthologous Gene

Mouse[3]  NM_011824
Rat [0]  

Chromosomal Region

15q13.3  [33,010,175  -  33,026,870]

Gene Family (Interpro ID)

IPR006207  Cystine knot, C-terminal

Link to Pubmed  (Pubmed ID)

9660951
10026205
10744662
10894942
12135612
12477932
12808456
12885271
14702039
15064755
15340161
15489334
15528323
15539560
15957132
16545136
16606614
16816361
17003113
17015616
17207965
17403698
17975199
17980714
18314105
18469115
18545679
19031438
19453261
19505925
19577778
19597895
20023658
20042676
20150533
20610440
20659471
20660291
20705941
21214523
21655089
21761138
21935575
21978004
22048656
22160428
22525892
22561515
22576962
22706573
22839096
22870311
23266556
23548835
23659962
23826422
24003215
24125106
24233491
24550394
24788093

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0002042  cell migration involved in sprouting angiogenesis
GO:0000902  cell morphogenesis
GO:0007267  cell-cell signaling
GO:0030199  collagen fibril organization
GO:0048263  determination of dorsal identity
GO:0030326  embryonic limb morphogenesis
GO:0003337  mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0030514  negative regulation of BMP signaling pathway
GO:0030502  negative regulation of bone mineralization
GO:0046851  negative regulation of bone remodeling
GO:0090191  negative regulation of branching involved in ureteric bud morphogenesis
GO:0030308  negative regulation of cell growth
GO:0090027  negative regulation of monocyte chemotaxis
GO:0033689  negative regulation of osteoblast proliferation
GO:0060394  negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0045766  positive regulation of angiogenesis
GO:0090190  positive regulation of branching involved in ureteric bud morphogenesis
GO:0008284  positive regulation of cell proliferation
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0002092  positive regulation of receptor internalization
GO:0051973  positive regulation of telomerase activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0003257  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0009954  proximal/distal pattern formation
GO:0010717  regulation of epithelial to mesenchymal transition
GO:0051893  regulation of focal adhesion formation
GO:0032872  regulation of stress-activated MAPK cascade
GO:0060676  ureteric bud formation

Cellular Component

GO:0009986  cell surface
GO:0005615  extracellular space

Molecular Function

GO:0005125  cytokine activity
GO:0016015  morphogen activity
GO:0005515  protein binding
GO:0030296  protein tyrosine kinase activator activity
GO:0048018  receptor agonist activity
GO:0043184  vascular endothelial growth factor receptor 2 binding