growth hormone receptor

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Synonym

GHBP, GHR, growth hormone receptor, Somatotropin receptor, Growth hormone receptor precursor, GH receptor

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:3.69 cerebellum:3.38 brain stem:3.81 corpus callosum/glia:3.74 pineal gland:- peripheral nerve:5.51 spine:4.35 retina:- eye:- artery/aorta:6.85 vein:5.77 lymphnode:4.53 peripheral blood:- spleen:5 thymus:4.42 bone marrow:4.83 adipose:9.30 bone:- skin:6.58
CAGE cerebrum:1.35 cerebellum:- brain stem:1.48 corpus callosum/glia:1.23 pineal gland:1.81 peripheral nerve:- spine:1.59 retina:- eye:- artery/aorta:2.81 vein:3.29 lymphnode:1.62 peripheral blood:- spleen:2.11 thymus:0.74 bone marrow:- adipose:4.75 bone:- skin:-
RNA-seq cerebrum:0.13 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.50 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.73 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.46 placenta:5.19 prostate:7.39 ovary:5.69 testis:3.79 heart:6.46 muscle:8.26 esophagus:5.07 stomach:5.36 intestine:5.47 colon:4.72 liver/hepato:10.09 lung:5.61 bladder:- kidney:6.23 pituitary:3.55 thyroid/parathyroid:5.91 adrenal gland:6.01 pancreas:4.71 breast:6.88 salivary:4.33
CAGE uterus:2.70 placenta:2.48 prostate:3.21 ovary:2.69 testis:1.89 heart:2.91 muscle:3.97 esophagus:2.07 stomach:- intestine:1.94 colon:2.64     liver/hepato:4.67    lung:2.22 bladder:2.48 kidney:2.69 pituitary:1.36 thyroid/parathyroid:2.12 adrenal gland:- pancreas:1.59 breast:4.43 salivary:1.28
RNA-seq uterus:- placenta:- prostate:0.75 ovary:0.71 testis:0.26 heart:0.41 muscle:2.73 esophagus:- stomach:- intestine:- colon:0.69     liver/hepato:1.27        lung:0.78    bladder:- kidney:0.40 pituitary:- thyroid/parathyroid:1.18 adrenal gland:0 pancreas:- breast:3.80 salivary:-

IDs

Refseq ID NM_000163
Gene ID 2690
Unigene ID -
Probe set ID 205498_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000112964
GTEx ID ENSG00000112964

Orthologous Gene

Mouse[5]  NM_001048147, NM_001048178, NM_010284
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1284474
1301391
1549776
1569971
1955498
1999489
2369845
2406245
2776481
2776934
2779634
2813379
2825030
7535773
7540178
7565946
7608270
7782332
7862673
7984244
8063815
8137822
8360189
8421103
8488849
8504296
8636303
8702683
8855247
8889548
8901592
8923468
8943276
9024232
9058373
9075743
9121492
9140387
9341147
9353194
9360546
9632636
9814495
9851797
9886834
10391209
10502458
10551776
10567404
10585430
10715538
10764769
10866662
10870033
10976913
11158048
11316758
11456111
11513560
11719288
11785980
11851338
11924928
12088868
12135564
12423626
12477932
12552091
12586763
12611612
12679461
12735788
12756585
12846737
12907755
14517972
14551225
14678285
14718574
15001620
15042833
15061875
15085728
15196705
15563602
15583394
15743767
15751611
15755445
15857837
15891957
16116438
16213173
16246940
16291702
16291706
16352683
16372230
16381017
16394090
16572267
16582564
16722931
16741161
16757551
17003087
17082603
17090634
17137217
17148568
17220348
17274879
17287408
17289896
17347571
17350302
17405847
17426087
17462934
17474147
17500058
17514010
17537658
17546465
17547682
17555507
17555512
17573420
17598975
17622584
17666591
17671221
17706034
17711923
17761766
17764692
17849745
17884454
17925340
17957148
17973940
17986824
17991764
18001530
18031312
18054353
18073295
18160465
18182091
18204098
18299312
18397980
18401200
18404972
18420710
18445665
18488018
18611972
18636124
18648510
18676680
18793346
18820897
18832799
18950677
18974274
19050057
19064572
19084217
19089622
19116245
19116246
19167335
19169479
19170196
19189684
19204726
19336510
19344073
19344888
19407498
19417039
19439509
19447840
19453261
19486024
19487270
19540305
19541519
19584188
19605543
19625176
19634821
19681916
19692168
19701549
19730683
19812236
19815155
19842933
19844941
19850678
19864451
19913121
20013551
20039885
20105189
20149700
20219401
20382688
20421852
20447065
20453000
20540360
20592127
20628086
20634197
20664532
20734064
20810604
20849725
20855935
21073120
21195069
21238539
21273694
21310852
21347402
21386804
21436896
21470351
21623854
21744231
21820924
21846964
21900382
21913951
21980433
22034227
22052808
22077984
22162472
22278433
22386777
22433856
22456308
22702213
23006423
23047741
23162096
23192981
23288882
23426819
23607312
23696513
23740230
23782942
23999134
24022308
24114431
24134847
24280222
24307807
24412931

Gene Ontology  (GO ID)

Biological Process

GO:0006103  2-oxoglutarate metabolic process
GO:0042977  activation of JAK2 kinase activity
GO:0000187  activation of MAPK activity
GO:0000255  allantoin metabolic process
GO:0060351  cartilage development involved in endochondral bone morphogenesis
GO:0032870  cellular response to hormone stimulus
GO:0032869  cellular response to insulin stimulus
GO:0006101  citrate metabolic process
GO:0006600  creatine metabolic process
GO:0046449  creatinine metabolic process
GO:0006897  endocytosis
GO:0006631  fatty acid metabolic process
GO:0060396  growth hormone receptor signaling pathway
GO:0009755  hormone-mediated signaling pathway
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0006549  isoleucine metabolic process
GO:0007259  JAK-STAT cascade
GO:0060397  JAK-STAT cascade involved in growth hormone signaling pathway
GO:0044236  multicellular organismal metabolic process
GO:0006107  oxaloacetate metabolic process
GO:0045597  positive regulation of cell differentiation
GO:0040018  positive regulation of multicellular organism growth
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0031623  receptor internalization
GO:0040014  regulation of multicellular organism growth
GO:0046898  response to cycloheximide
GO:0032355  response to estradiol stimulus
GO:0032094  response to food
GO:0051384  response to glucocorticoid stimulus
GO:0070555  response to interleukin-1
GO:0043278  response to morphine
GO:0006105  succinate metabolic process
GO:0019530  taurine metabolic process
GO:0006573  valine metabolic process

Cellular Component

GO:0043025  cell soma
GO:0009986  cell surface
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0019898  extrinsic to membrane
GO:0070195  growth hormone receptor complex
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0043235  receptor complex

Molecular Function

GO:0019838  growth factor binding
GO:0004903  growth hormone receptor activity
GO:0017046  peptide hormone binding
GO:0070064  proline-rich region binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0019901  protein kinase binding
GO:0019903  protein phosphatase binding
GO:0042169  SH2 domain binding