gap junction protein, alpha 1, 43kDa

Synonym

CX43, GJAL, ODD, DFNB38, Cx43, ODDD, Gap junction 43 kDa heart protein, ODOD, Gap junction alpha-1 protein, GJA1, SDTY3, Connexin-43, gap junction protein, alpha 1, 43kDa (connexin 43)

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:220.40

cerebellum:75.60

brain stem:-

corpus callosum/glia:1195.60

pineal gland:148.30

peripheral nerve:122.70

spine:-

retina:118.60

eye:193.90

artery/aorta:1498.80

vein:199.90

lymphnode:-

peripheral blood:-

spleen:18.90

thymus:412.30

bone marrow:78.70

adipose:282.30

bone:524.60

skin:307.20

GeneChip

cerebrum:10.34

cerebellum:9

brain stem:10.47

corpus callosum/glia:10.62

pineal gland:-

peripheral nerve:8.27

spine:11.86

retina:-

eye:-

artery/aorta:9.80

vein:10.08

lymphnode:8.05

peripheral blood:-

spleen:5.21

thymus:7.20

bone marrow:4.93

adipose:9.43

bone:-

skin:10.55

CAGE

cerebrum:4.66

cerebellum:-

brain stem:4.17

corpus callosum/glia:4.32

pineal gland:2.96

peripheral nerve:-

spine:5.23

retina:-

eye:-

artery/aorta:4.97

vein:2.69

lymphnode:2.03

peripheral blood:-

spleen:0.66

thymus:0.80

bone marrow:-

adipose:3.65

bone:-

skin:-

RNA-seq

cerebrum:7.50

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:5.75

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:6.96

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:264.30

placenta:214.90

prostate:90.10

ovary:37.30

testis:95.20

heart:255.40

muscle:60.30

esophagus:-

stomach:21.20

intestine:64.80

colon:76.30

liver/hepato:10.60

lung:122.20

bladder:125.60

kidney:10.40

pituitary:-

thyroid/parathyroid:491.20

adrenal gland:406.30

pancreas:97.80

breast:46.50

salivary:-

GeneChip

uterus:10.53

placenta:9.67

prostate:9.74

ovary:9.40

testis:8.33

heart:10.48

muscle:6.36

esophagus:9.25

stomach:8.17

intestine:8.65

colon:6.80

liver/hepato:4.42

lung:9.49

bladder:-

kidney:6.34

pituitary:6.70

thyroid/parathyroid:10.46

adrenal gland:10.79

pancreas:6.60

breast:9.93

salivary:6.98

CAGE

uterus:3.89

placenta:4.28

prostate:3.38

ovary:3.03

testis:3.02

heart:3.98

muscle:2.23

esophagus:3.76

stomach:-

intestine:2.63

colon:2.03

liver/hepato:0.78

lung:3.42

bladder:3.92

kidney:2.10

pituitary:3.06

thyroid/parathyroid:4.19

adrenal gland:-

pancreas:2.18

breast:3.76

salivary:1.28

RNA-seq

uterus:-

placenta:-

prostate:5.78

ovary:5.45

testis:5.16

heart:6.08

muscle:2.47

esophagus:-

stomach:-

intestine:-

colon:5.76

liver/hepato:1.11

lung:7.19

bladder:-

kidney:4.06

pituitary:-

thyroid/parathyroid:6.63

adrenal gland:5.24

pancreas:-

breast:5.97

salivary:-

IDs

Refseq ID	NM_000165
Gene ID	2697
Unigene ID	Hs.74471
Probe set ID	201667_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000152661
GTEx ID	ENSG00000152661

Orthologous Gene

Mouse[12]	NM_010288
Rat [0]

Chromosomal Region

6q22.31 [121,756,791 - 121,770,873]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000500	Connexins
IPR002261	Gap junction alpha-1 protein (Cx43)

Gene Ontology (GO ID)

Biological Process

GO:0007512	adult heart development
GO:0006915	apoptosis
GO:0015867	ATP transport
GO:0003294	atrial ventricular junction remodeling
GO:0048514	blood vessel morphogenesis
GO:0010643	cell communication by chemical coupling
GO:0010644	cell communication by electrical coupling
GO:0007267	cell-cell signaling
GO:0002070	epithelial cell maturation
GO:0016264	gap junction assembly
GO:0007507	heart development
GO:0001947	heart looping
GO:0001701	in utero embryonic development
GO:0002088	lens development in camera-type eye
GO:0060174	limb bud formation
GO:0016044	membrane organization
GO:0060156	milk ejection
GO:0006936	muscle contraction
GO:0008285	negative regulation of cell proliferation
GO:0010629	negative regulation of gene expression
GO:0001764	neuron migration
GO:0048812	neuron projection morphogenesis
GO:0001649	osteoblast differentiation
GO:0010628	positive regulation of gene expression
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045732	positive regulation of protein catabolic process
GO:0045844	positive regulation of striated muscle tissue development
GO:0051259	protein oligomerization
GO:0060371	regulation of atrial cardiomyocyte membrane depolarization
GO:0030500	regulation of bone mineralization
GO:0046850	regulation of bone remodeling
GO:0051924	regulation of calcium ion transport
GO:0060373	regulation of ventricular cardiomyocyte membrane depolarization
GO:0060307	regulation of ventricular cardiomyocyte membrane repolarization
GO:0043434	response to peptide hormone stimulus
GO:0009268	response to pH
GO:0007165	signal transduction
GO:0043403	skeletal muscle tissue regeneration
GO:0006810	transport
GO:0010232	vascular transport

Cellular Component

GO:0016324	apical plasma membrane
GO:0005922	connexon complex
GO:0043292	contractile fiber
GO:0005829	cytosol
GO:0005769	early endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005916	fascia adherens
GO:0005921	gap junction
GO:0005794	Golgi apparatus
GO:0000139	Golgi membrane
GO:0030660	Golgi-associated vesicle membrane
GO:0005887	integral to plasma membrane
GO:0014704	intercalated disc
GO:0005882	intermediate filament
GO:0016328	lateral plasma membrane
GO:0005764	lysosome
GO:0045121	membrane raft
GO:0005741	mitochondrial outer membrane
GO:0005771	multivesicular body
GO:0005886	plasma membrane

Molecular Function

GO:0048487	beta-tubulin binding
GO:0005243	gap junction channel activity
GO:0015075	ion transmembrane transporter activity
GO:0030165	PDZ domain binding
GO:0005515	protein binding
GO:0005102	receptor binding
GO:0017124	SH3 domain binding
GO:0004871	signal transducer activity

gap junction protein, alpha 1, 43kDa

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function