PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

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Synonym

hPso4, NMP200, Nuclear matrix protein 200, Pre-mRNA-splicing factor 19, hPSO4, PRP19, UBOX4, PRPF19, PRP19/PSO4 homolog, PRP19/PSO4 homolog (S. cerevisiae), PSO4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:14.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:112.30 retina:- eye:76.40 artery/aorta:30 vein:- lymphnode:40.40 peripheral blood:36.40 spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:- skin:19.20
GeneChip cerebrum:8.24 cerebellum:8.33 brain stem:8.33 corpus callosum/glia:7.63 pineal gland:- peripheral nerve:7.73 spine:7.80 retina:- eye:- artery/aorta:7.73 vein:7.40 lymphnode:7.93 peripheral blood:- spleen:8.09 thymus:8.08 bone marrow:7.71 adipose:7.50 bone:- skin:7.94
CAGE cerebrum:4.67 cerebellum:- brain stem:4.52 corpus callosum/glia:4.13 pineal gland:4.29 peripheral nerve:- spine:4.23 retina:- eye:- artery/aorta:3.96 vein:4.22 lymphnode:4.38 peripheral blood:- spleen:4.36 thymus:4.69 bone marrow:- adipose:3.87 bone:- skin:-
RNA-seq cerebrum:5.51 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.43 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.47 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:40.10 prostate:11.30 ovary:37.30 testis:21.60 heart:51.10 muscle:- esophagus:- stomach:191.20 intestine:- colon:101.80     liver/hepato:-        lung:68.40    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:18.60 salivary:-
GeneChip uterus:7.87 placenta:7.05 prostate:8.29 ovary:8.11 testis:7.56 heart:7.25 muscle:6.95 esophagus:8.16 stomach:7.76 intestine:7.56 colon:7.96 liver/hepato:7.76 lung:7.45 bladder:- kidney:7.54 pituitary:8.41 thyroid/parathyroid:7.72 adrenal gland:8.08 pancreas:7.21 breast:8.08 salivary:7.65
CAGE uterus:4.11 placenta:4.04 prostate:4.29 ovary:4.49 testis:4.03 heart:3.87 muscle:4.22 esophagus:4.42 stomach:- intestine:4.00 colon:4.21     liver/hepato:4.56    lung:3.85 bladder:4.27 kidney:4.08 pituitary:4.49 thyroid/parathyroid:4.12 adrenal gland:- pancreas:4.18 breast:4.40 salivary:4.08
RNA-seq uterus:- placenta:- prostate:4.93 ovary:5.72 testis:5.33 heart:3.14 muscle:4.63 esophagus:- stomach:- intestine:- colon:4.56     liver/hepato:4.48        lung:3.93    bladder:- kidney:4.56 pituitary:- thyroid/parathyroid:5.52 adrenal gland:5.72 pancreas:- breast:4.73 salivary:-

Gene Information

IDs

Refseq ID NM_014502
Gene ID 27339
Unigene ID Hs.502705
Probe set ID 203103_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000110107
GTEx ID ENSG00000110107

Orthologous Gene

Mouse[3]  NM_134129
Rat[1]  NM_139333

Chromosomal Region

11q12.2  [60,658,202  -  60,674,060]

Gene Family (Interpro ID)

IPR020472  G-protein beta WD-40 repeat, region
IPR003613  U box domain
IPR001680  WD40 repeat
IPR019782  WD40 repeat 2
IPR019781  WD40 repeat, subgroup
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain
IPR013083  Zinc finger, RING/FYVE/PHD-type

Link to Pubmed  (Pubmed ID)

10404385
11082287
11101529
11435423
11790298
11991638
12429849
12477932
12960389
15175653
15324660
15489334
15635413
15660529
16159877
16189514
16196087
16223718
16332694
16388800
17276391
17283042
17332742
17353931
18263876
19188445
19596686
19641227
19738201
19946888
20020773
20176811
20360068
20416268
20508642
20595234
20599946
21081666
21139048
21145461
21149631
21385873
21536736
21549307
21639856
21890473
21906983
21988832
22053931
22079093
22174317
22178446
22365833
22446626
22529335
22569250
22751105
22863883
22939624
22939629
22967061
23000965
23022380
23022480
23084401
23220010
23455922
23862649
24069358
24244333
24332808
24457600
24654937
24778252
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006281  DNA repair
GO:0001833  inner cell mass cell proliferation
GO:0008610  lipid biosynthetic process
GO:0045665  negative regulation of neuron differentiation
GO:0000398  nuclear mRNA splicing, via spliceosome
GO:0048711  positive regulation of astrocyte differentiation
GO:0048026  positive regulation of nuclear mRNA splicing, via spliceosome
GO:0000209  protein polyubiquitination
GO:0000245  spliceosome assembly

Cellular Component

GO:0071013  catalytic step 2 spliceosome
GO:0005737  cytoplasm
GO:0005811  lipid particle
GO:0016607  nuclear speck
GO:0005634  nucleus
GO:0000974  Prp19 complex
GO:0005819  spindle
GO:0000151  ubiquitin ligase complex

Molecular Function

GO:0003677  DNA binding
GO:0042802  identical protein binding
GO:0005515  protein binding
GO:0004842  ubiquitin-protein ligase activity
GO:0034450  ubiquitin-ubiquitin ligase activity