GLI family zinc finger 3

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Synonym

PHS, PAP-A, PAPB, PAPA1, ACLS, PAPA, PPDIV, GCPS, GLI3, Zinc finger protein GLI3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:92 spine:- retina:- eye:17.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:19.70 adipose:- bone:25.60 skin:9.60
GeneChip cerebrum:6.91 cerebellum:6.52 brain stem:7.05 corpus callosum/glia:6.81 pineal gland:- peripheral nerve:6.80 spine:6.59 retina:- eye:- artery/aorta:6.75 vein:6.88 lymphnode:6.62 peripheral blood:- spleen:6.41 thymus:6.38 bone marrow:6.59 adipose:7.26 bone:- skin:7.28
CAGE cerebrum:1.62 cerebellum:- brain stem:0.93 corpus callosum/glia:1.60 pineal gland:0.56 peripheral nerve:- spine:0.96 retina:- eye:- artery/aorta:2.50 vein:1.95 lymphnode:1.88 peripheral blood:- spleen:0.84 thymus:1.35 bone marrow:- adipose:2.62 bone:- skin:-
RNA-seq cerebrum:0.72 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.28 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.58 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:11.30 ovary:- testis:- heart:63.90 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:4.90    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:7.52 placenta:7.76 prostate:7.09 ovary:7.45 testis:6.59 heart:7.04 muscle:6.93 esophagus:6.96 stomach:7.09 intestine:6.89 colon:7.45 liver/hepato:6.64 lung:6.65 bladder:- kidney:6.86 pituitary:6.75 thyroid/parathyroid:7.13 adrenal gland:6.93 pancreas:6.78 breast:7.78 salivary:6.91
CAGE uterus:3.91 placenta:3.12 prostate:3.05 ovary:3.28 testis:1.76 heart:1.53 muscle:1.63 esophagus:2.60 stomach:- intestine:1.96 colon:2.71     liver/hepato:0    lung:2.36 bladder:2.54 kidney:0.74 pituitary:1.00 thyroid/parathyroid:2.01 adrenal gland:- pancreas:1.42 breast:2.34 salivary:1.58
RNA-seq uterus:- placenta:- prostate:1.92 ovary:3.53 testis:1.50 heart:0.66 muscle:0.51 esophagus:- stomach:- intestine:- colon:2.04     liver/hepato:0.06        lung:1.25    bladder:- kidney:0.66 pituitary:- thyroid/parathyroid:2.06 adrenal gland:1.43 pancreas:- breast:2.10 salivary:-

Gene Information

IDs

Refseq ID NM_000168
Gene ID 2737
Unigene ID Hs.21509
Probe set ID 205201_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000106571
GTEx ID ENSG00000106571

Orthologous Gene

Mouse[1]  NM_008130
Rat [0]  

Chromosomal Region

7p14.1  [42,000,548  -  42,277,469]

Gene Family (Interpro ID)

IPR015880  Zinc finger, C2H2-like
IPR007087  Zinc finger, C2H2-type

Link to Pubmed  (Pubmed ID)

1879832
2118997
2850480
7566098
7829101
8378770
9054938
9302279
9354785
9402960
9843199
9847074
10075717
10077605
10441342
10441570
10564661
10678662
10693759
10806483
11001584
11238441
11960000
12142027
12414818
12435627
12477932
12545275
12575660
12575661
12794692
12853948
14608643
14611647
15390181
15739154
15811011
16254602
16344560
16371461
16705181
17000779
17029207
17081983
17283082
17331723
17400206
17426814
17764085
18000979
18029348
18057099
18057317
18252217
18478223
18559511
18655123
19084012
19095771
19389374
19432668
19453261
19592253
19593328
19729595
19829694
19925654
19996099
20050020
20201963
20301619
20301638
20301753
20425471
20426846
20583172
20610541
20634891
20672375
20711444
21069353
21108399
21209912
21320477
21326280
21531006
21921029
21963094
22036096
22227409
22535956
22678783
22903559
22984994
23091001
23176625
23293081
23326517
23334564
23382691
23454725
23667531
23736020
24102645
24174682

Gene Ontology  (GO ID)

Biological Process

GO:0060873  anterior semicircular canal development
GO:0009952  anterior/posterior pattern formation
GO:0060840  artery development
GO:0007411  axon guidance
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0048593  camera-type eye morphogenesis
GO:0021801  cerebral cortex radial glia guided migration
GO:0048589  developmental growth
GO:0048557  embryonic digestive tract morphogenesis
GO:0042733  embryonic digit morphogenesis
GO:0048566  embryonic gut development
GO:0048704  embryonic skeletal system morphogenesis
GO:0021798  forebrain dorsal/ventral pattern formation
GO:0060364  frontal suture morphogenesis
GO:0007507  heart development
GO:0007442  hindgut morphogenesis
GO:0001701  in utero embryonic development
GO:0060366  lambdoid suture morphogenesis
GO:0022018  lateral ganglionic eminence cell proliferation
GO:0060875  lateral semicircular canal development
GO:0035108  limb morphogenesis
GO:0030324  lung development
GO:0060594  mammary gland specification
GO:0030318  melanocyte differentiation
GO:0001656  metanephros development
GO:0046639  negative regulation of alpha-beta T cell differentiation
GO:0043066  negative regulation of apoptosis
GO:0008285  negative regulation of cell proliferation
GO:0045665  negative regulation of neuron differentiation
GO:0045879  negative regulation of smoothened signaling pathway
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0045060  negative thymic T cell selection
GO:0043585  nose morphogenesis
GO:0042475  odontogenesis of dentine-containing tooth
GO:0048709  oligodendrocyte differentiation
GO:0021631  optic nerve morphogenesis
GO:0060021  palate development
GO:0046638  positive regulation of alpha-beta T cell differentiation
GO:0032332  positive regulation of chondrocyte differentiation
GO:0002052  positive regulation of neuroblast proliferation
GO:0045669  positive regulation of osteoblast differentiation
GO:0042307  positive regulation of protein import into nucleus
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0016485  protein processing
GO:0009954  proximal/distal pattern formation
GO:0021861  radial glial cell differentiation in the forebrain
GO:0060367  sagittal suture morphogenesis
GO:0007224  smoothened signaling pathway
GO:0060831  smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0021776  smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021775  smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0033077  T cell differentiation in the thymus
GO:0070242  thymocyte apoptosis
GO:0043586  tongue development
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005929  cilium
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0043231  intracellular membrane-bounded organelle
GO:0016592  mediator complex
GO:0016607  nuclear speck
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0017053  transcriptional repressor complex

Molecular Function

GO:0008013  beta-catenin binding
GO:0003682  chromatin binding
GO:0035035  histone acetyltransferase binding
GO:0042826  histone deacetylase binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity