guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

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Synonym

GNAL

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:124.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:122.70 spine:224.60 retina:- eye:41.10 artery/aorta:60 vein:133.30 lymphnode:50.60 peripheral blood:36.40 spleen:- thymus:38.70 bone marrow:- adipose:80.70 bone:38.40 skin:72
GeneChip cerebrum:8.10 cerebellum:6.36 brain stem:7.50 corpus callosum/glia:6.24 pineal gland:- peripheral nerve:7.30 spine:6.88 retina:- eye:- artery/aorta:6.62 vein:6.81 lymphnode:6.17 peripheral blood:- spleen:5.51 thymus:5.81 bone marrow:5.60 adipose:6.70 bone:- skin:6.69
CAGE cerebrum:3.77 cerebellum:- brain stem:2.95 corpus callosum/glia:2.64 pineal gland:1.62 peripheral nerve:- spine:2.85 retina:- eye:- artery/aorta:2.50 vein:2.09 lymphnode:1.89 peripheral blood:- spleen:1.58 thymus:1.60 bone marrow:- adipose:2.43 bone:- skin:-
RNA-seq cerebrum:0.76 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.84 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.68 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:80.10 prostate:11.30 ovary:74.50 testis:30.30 heart:38.30 muscle:20.10 esophagus:- stomach:21.20 intestine:64.80 colon:42.40     liver/hepato:137.20        lung:44    bladder:125.60 kidney:20.80 pituitary:232 thyroid/parathyroid:163.70 adrenal gland:- pancreas:88.90 breast:27.90 salivary:-
GeneChip uterus:6.20 placenta:5.21 prostate:6.99 ovary:5.91 testis:6.02 heart:5.93 muscle:7.02 esophagus:6.33 stomach:5.95 intestine:6.04 colon:5.88 liver/hepato:5.31 lung:5.70 bladder:- kidney:5.66 pituitary:8.46 thyroid/parathyroid:6.68 adrenal gland:5.65 pancreas:5.97 breast:6.62 salivary:6.14
CAGE uterus:2.55 placenta:0.68 prostate:3.20 ovary:2.24 testis:2.49 heart:1.57 muscle:1.26 esophagus:2.60 stomach:- intestine:1.48 colon:1.29     liver/hepato:0.84    lung:1.25 bladder:3.66 kidney:1.80 pituitary:4.35 thyroid/parathyroid:2.25 adrenal gland:- pancreas:0.58 breast:2.27 salivary:1.58
RNA-seq uterus:- placenta:- prostate:2.29 ovary:0.40 testis:0.74 heart:0.37 muscle:0.09 esophagus:- stomach:- intestine:- colon:0.60     liver/hepato:0.00        lung:0.71    bladder:- kidney:0.22 pituitary:- thyroid/parathyroid:0.82 adrenal gland:1.13 pancreas:- breast:0.68 salivary:-

Gene Information

IDs

Refseq ID NM_182978
Gene ID 2774
Unigene ID Hs.136295
Probe set ID 213924_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000141404
GTEx ID ENSG00000141404

Orthologous Gene

Mouse[2]  NM_010307, NM_177137
Rat [0]  

Chromosomal Region

18p11.21  [11,689,184  -  11,885,684]

Gene Family (Interpro ID)

IPR000367  G-protein alpha subunit, group S
IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit

Link to Pubmed  (Pubmed ID)

1302014
7937899
8243272
8663304
8889548
10026232
11032382
11901355
12037684
12477932
12782961
14702039
14993377
15342556
16044173
16344560
16818375
17166517
17207965
19245791
19328558
19615732
20133939
20301334
20360068
20379614
21110914
21139048
21890473
21906983
21963094
21987572
22120635
22505724
23000965
23222958
23449625
23459443
23759320
24535567

Gene Ontology  (GO ID)

Biological Process

GO:0007190  activation of adenylate cyclase activity
GO:0007191  activation of adenylate cyclase activity by dopamine receptor signaling pathway
GO:0007189  activation of adenylate cyclase activity by G-protein signaling pathway
GO:0007193  inhibition of adenylate cyclase activity by G-protein signaling pathway
GO:0001975  response to amphetamine
GO:0031000  response to caffeine
GO:0007608  sensory perception of smell
GO:0007165  signal transduction
GO:0007268  synaptic transmission

Cellular Component

GO:0031234  extrinsic to internal side of plasma membrane
GO:0005834  heterotrimeric G-protein complex
GO:0005886  plasma membrane

Molecular Function

GO:0031683  G-protein beta/gamma-subunit binding
GO:0001664  G-protein-coupled receptor binding
GO:0005525  GTP binding
GO:0003924  GTPase activity
GO:0046872  metal ion binding
GO:0004871  signal transducer activity