ankyrin 2, neuronal

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Synonym

LQT4, Brain ankyrin, long (electrocardiographic) QT syndrome 4, ankyrin 2, neuronal, Ankyrin, nonerythroid, Ankyrin-B, DKFZp686P0948, Ankyrin-2, FLJ38277, ANK2, DKFZp686M09125

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:296.30 cerebellum:151.10 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:153.40 spine:449.20 retina:355.90 eye:199.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:37.80 thymus:38.70 bone marrow:- adipose:40.30 bone:38.40 skin:33.60
GeneChip cerebrum:10.20 cerebellum:10.11 brain stem:10.50 corpus callosum/glia:9.60 pineal gland:- peripheral nerve:9.93 spine:9.85 retina:- eye:- artery/aorta:7.41 vein:8.78 lymphnode:6.25 peripheral blood:- spleen:7.88 thymus:5.06 bone marrow:4.01 adipose:7.77 bone:- skin:7.28
CAGE cerebrum:5.63 cerebellum:- brain stem:5.40 corpus callosum/glia:5.28 pineal gland:4.85 peripheral nerve:- spine:5.32 retina:- eye:- artery/aorta:3.42 vein:3.51 lymphnode:2.63 peripheral blood:- spleen:3.51 thymus:1.35 bone marrow:- adipose:4.25 bone:- skin:-
RNA-seq cerebrum:3.61 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.64 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.46 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:- prostate:33.80 ovary:74.50 testis:43.30 heart:127.70 muscle:120.50 esophagus:- stomach:- intestine:- colon:42.40     liver/hepato:21.10        lung:53.80    bladder:- kidney:218.30 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:35.60 breast:- salivary:-
GeneChip uterus:7.75 placenta:4.19 prostate:6.30 ovary:7.39 testis:5.37 heart:8.55 muscle:8.18 esophagus:6.36 stomach:6.53 intestine:6.44 colon:6.04 liver/hepato:4.13 lung:5.29 bladder:- kidney:9.49 pituitary:7.87 thyroid/parathyroid:6.80 adrenal gland:6.54 pancreas:4.20 breast:6.98 salivary:4.56
CAGE uterus:3.99 placenta:1.20 prostate:3.31 ovary:3.71 testis:3.19 heart:3.83 muscle:3.17 esophagus:3.29 stomach:- intestine:2.84 colon:3.31     liver/hepato:0.26    lung:2.30 bladder:3.30 kidney:4.18 pituitary:4.20 thyroid/parathyroid:2.99 adrenal gland:- pancreas:0.58 breast:2.74 salivary:2.22
RNA-seq uterus:- placenta:- prostate:0.29 ovary:0.26 testis:0.62 heart:4.00 muscle:1.39 esophagus:- stomach:- intestine:- colon:0.57     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.40 adrenal gland:0.33 pancreas:- breast:0.21 salivary:-

Gene Information

IDs

Refseq ID NM_001127493
Gene ID 287
Unigene ID Hs.620557
Probe set ID 202920_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000145362
GTEx ID ENSG00000145362

Orthologous Gene

Mouse[2]  NM_001034168, NM_178655
Rat[2]  NM_001034168, NM_178655

Chromosomal Region

4q25  [113,739,265  -  114,309,884]

Gene Family (Interpro ID)

IPR000488  Death
IPR011029  DEATH-like

Link to Pubmed  (Pubmed ID)

1830053
1833308
2968981
7485162
8253844
8619474
9110174
9832558
10579720
11149946
11449000
11781319
12477932
12527750
12571597
14593108
14657231
14702039
15075330
15146197
15178757
15262991
15310273
15611082
15647482
15851119
16253912
16292983
16597699
16864073
17043677
17081983
17161064
17178715
17242276
17456239
17474147
17940615
18052691
18275062
18303017
18782775
18790697
18832177
19098452
19109891
19913121
20031550
20080650
20195357
20332099
20379614
20471030
20573981
20628086
20682791
21139048
21859974
21890473
22219177
22778271
22861190
23142288
23569209
23720494

Gene Ontology  (GO ID)

Biological Process

GO:0003283  atrial septum development
GO:0007411  axon guidance
GO:0060048  cardiac muscle contraction
GO:0006874  cellular calcium ion homeostasis
GO:0034613  cellular protein localization
GO:0051928  positive regulation of calcium ion transport
GO:0010628  positive regulation of gene expression
GO:0043268  positive regulation of potassium ion transport
GO:0034394  protein localization at cell surface
GO:0070972  protein localization in endoplasmic reticulum
GO:0033365  protein localization in organelle
GO:0050821  protein stabilization
GO:0051924  regulation of calcium ion transport
GO:0055117  regulation of cardiac muscle contraction
GO:0010882  regulation of cardiac muscle contraction by calcium ion signaling
GO:0010881  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0002027  regulation of heart rate
GO:0031647  regulation of protein stability
GO:0051279  regulation of release of sequestered calcium ion into cytosol
GO:0060307  regulation of ventricular cardiomyocyte membrane repolarization
GO:0070296  sarcoplasmic reticulum calcium ion transport
GO:0033292  T-tubule organization

Cellular Component

GO:0031672  A band
GO:0016324  apical plasma membrane
GO:0016323  basolateral plasma membrane
GO:0043034  costamere
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0005887  integral to plasma membrane
GO:0014704  intercalated disc
GO:0005622  intracellular
GO:0031430  M band
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0045211  postsynaptic membrane
GO:0042383  sarcolemma
GO:0030315  T-tubule
GO:0030018  Z disc

Molecular Function

GO:0051117  ATPase binding
GO:0019899  enzyme binding
GO:0015459  potassium channel regulator activity
GO:0005515  protein binding
GO:0030674  protein binding, bridging
GO:0019901  protein kinase binding
GO:0030507  spectrin binding