MAP kinase interacting serine/threonine kinase 2

 jump to detail

Synonym

MAP kinase signal-integrating kinase 2, GPRK7, G protein-coupled receptor kinase 7, MAP kinase interacting serine/threonine kinase 2, MKNK2, Mnk2, MNK2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:36.70 cerebellum:50.40 brain stem:- corpus callosum/glia:- pineal gland:148.30 peripheral nerve:30.70 spine:- retina:- eye:164.60 artery/aorta:60 vein:66.60 lymphnode:171.90 peripheral blood:36.40 spleen:56.70 thymus:154.60 bone marrow:98.40 adipose:121 bone:12.80 skin:57.60
GeneChip cerebrum:7.74 cerebellum:9.02 brain stem:7.62 corpus callosum/glia:7.97 pineal gland:- peripheral nerve:8.63 spine:8.01 retina:- eye:- artery/aorta:9.68 vein:8.75 lymphnode:10.05 peripheral blood:- spleen:10.59 thymus:9.19 bone marrow:9.76 adipose:9.99 bone:- skin:10.11
CAGE cerebrum:4.08 cerebellum:- brain stem:4.07 corpus callosum/glia:4.11 pineal gland:4.36 peripheral nerve:- spine:4.10 retina:- eye:- artery/aorta:4.91 vein:5.42 lymphnode:5.26 peripheral blood:- spleen:5.47 thymus:4.79 bone marrow:- adipose:5.61 bone:- skin:-
RNA-seq cerebrum:1.34 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.56 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.65 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:61.90 prostate:67.60 ovary:- testis:60.60 heart:89.40 muscle:221 esophagus:- stomach:106.20 intestine:97.20 colon:84.80     liver/hepato:10.60        lung:83.10    bladder:- kidney:72.80 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:17.80 breast:46.50 salivary:-
GeneChip uterus:8.95 placenta:9.41 prostate:9.76 ovary:9.02 testis:9.16 heart:9.71 muscle:10.85 esophagus:10.89 stomach:9.65 intestine:9.61 colon:9.39 liver/hepato:9.71 lung:10.09 bladder:- kidney:9.33 pituitary:8.94 thyroid/parathyroid:10.22 adrenal gland:10.05 pancreas:9.65 breast:9.73 salivary:10.36
CAGE uterus:4.69 placenta:4.92 prostate:5.16 ovary:4.85 testis:4.67 heart:5.24 muscle:7.34 esophagus:5.90 stomach:- intestine:4.89 colon:5.17     liver/hepato:4.67    lung:5.61 bladder:5.23 kidney:4.44 pituitary:4.36 thyroid/parathyroid:5.57 adrenal gland:- pancreas:5.44 breast:5.66 salivary:5.49
RNA-seq uterus:- placenta:- prostate:4.61 ovary:4.30 testis:4.18 heart:2.98 muscle:6.11 esophagus:- stomach:- intestine:- colon:5.67     liver/hepato:2.61        lung:3.30    bladder:- kidney:3.49 pituitary:- thyroid/parathyroid:5.04 adrenal gland:1.49 pancreas:- breast:4.51 salivary:-

Gene Information

IDs

Refseq ID NM_017572
Gene ID 2872
Unigene ID Hs.515032
Probe set ID 218205_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000099875
GTEx ID ENSG00000099875

Orthologous Gene

Mouse[4]  NM_021462
Rat [0]  

Chromosomal Region

19p13.3  [2,037,481  -  2,051,243]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8415712
8889548
9155017
11013076
11154262
11463832
12477932
12897141
14702039
15057824
15489334
16103188
16216586
16344560
16856496
18299328
18508592
19322201
20936779
21149447
21906983
21988832
22797067
23602568
23814052
23831578
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0007166  cell surface receptor linked signal transduction
GO:0071243  cellular response to arsenic
GO:0030097  hemopoiesis
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0006417  regulation of translation

Cellular Component

GO:0005737  cytoplasm
GO:0016605  PML body

Molecular Function

GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0004674  protein serine/threonine kinase activity