homeodomain interacting protein kinase 2

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PRO0593, hHIPk2, homeodomain-interacting protein kinase 2, Homeodomain-interacting protein kinase 2, HIPK2, homeodomain interacting protein kinase 2

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:18.20 spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:- skin:4.80
GeneChip cerebrum:8.03 cerebellum:6.88 brain stem:7.76 corpus callosum/glia:9.57 pineal gland:- peripheral nerve:6.04 spine:8.35 retina:- eye:- artery/aorta:6.41 vein:5.87 lymphnode:6.12 peripheral blood:- spleen:6.62 thymus:5.03 bone marrow:5.77 adipose:6.64 bone:- skin:5.71
CAGE cerebrum:5.28 cerebellum:- brain stem:5.71 corpus callosum/glia:6.52 pineal gland:5.00 peripheral nerve:- spine:5.52 retina:- eye:- artery/aorta:4.19 vein:4.04 lymphnode:4.12 peripheral blood:- spleen:4.51 thymus:3.31 bone marrow:- adipose:4.93 bone:- skin:-
RNA-seq cerebrum:2.04 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.87 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.88 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:90.10 ovary:- testis:- heart:- muscle:- esophagus:- stomach:21.20 intestine:- colon:25.40     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:55.80 salivary:-
GeneChip uterus:5.50 placenta:5.71 prostate:6.32 ovary:6.02 testis:5.14 heart:7.33 muscle:6.34 esophagus:6.84 stomach:7.36 intestine:6.28 colon:6.34 liver/hepato:7.53 lung:6.69 bladder:- kidney:7.95 pituitary:6.42 thyroid/parathyroid:6.48 adrenal gland:7.10 pancreas:6.77 breast:6.36 salivary:6.98
CAGE uterus:3.65 placenta:3.28 prostate:3.98 ovary:3.73 testis:3.26 heart:4.79 muscle:4.96 esophagus:3.81 stomach:- intestine:3.98 colon:3.83     liver/hepato:5.23    lung:4.48 bladder:3.84 kidney:5.05 pituitary:4.44 thyroid/parathyroid:4.08 adrenal gland:- pancreas:3.82 breast:5.09 salivary:3.93
RNA-seq uterus:- placenta:- prostate:1.22 ovary:0.74 testis:1.48 heart:3.48 muscle:2.00 esophagus:- stomach:- intestine:- colon:2.05     liver/hepato:2.80        lung:3.03    bladder:- kidney:2.75 pituitary:- thyroid/parathyroid:3.03 adrenal gland:0.52 pancreas:- breast:3.38 salivary:-


Refseq ID NM_022740
Gene ID 28996
Unigene ID Hs.632033
Probe set ID 219028_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000064393
GTEx ID ENSG00000064393

Orthologous Gene

Mouse[18]  NM_001136065, NM_010433
Rat[1]  NM_001108622, NM_010433

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0007628  adult walking behavior
GO:0009952  anterior/posterior pattern formation
GO:0071456  cellular response to hypoxia
GO:0042771  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0006978  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0048596  embryonic camera-type eye morphogenesis
GO:0060059  embryonic retina morphogenesis in camera-type eye
GO:0030218  erythrocyte differentiation
GO:0001654  eye development
GO:0060235  lens induction in camera-type eye
GO:0030514  negative regulation of BMP signaling pathway
GO:0043524  negative regulation of neuron apoptosis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0030182  neuron differentiation
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0030578  PML body organization
GO:0045766  positive regulation of angiogenesis
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0046330  positive regulation of JNK cascade
GO:0032092  positive regulation of protein binding
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0006468  protein amino acid phosphorylation
GO:0051726  regulation of cell cycle
GO:0010842  retina layer formation
GO:0060395  SMAD protein signal transduction
GO:0007224  smoothened signaling pathway
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0019048  virus-host interaction
GO:0050882  voluntary musculoskeletal movement

Cellular Component

GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0016604  nuclear body
GO:0031965  nuclear membrane
GO:0005634  nucleus
GO:0016605  PML body

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0003714  transcription corepressor activity
GO:0046790  virion binding