glutamate receptor, ionotropic, kainate 5

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Synonym

Glutamate receptor, ionotropic kainate 5 precursor, glutamate receptor, ionotropic, kainate 5, GRIK5, GRIK2, Glutamate receptor KA-2, KA2, EAA2, Excitatory amino acid receptor 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:26.10 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:41.10 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:8.57 cerebellum:8.61 brain stem:8.43 corpus callosum/glia:8.40 pineal gland:- peripheral nerve:8.08 spine:8.41 retina:- eye:- artery/aorta:7.85 vein:8.18 lymphnode:7.77 peripheral blood:- spleen:7.58 thymus:7.17 bone marrow:7.99 adipose:7.77 bone:- skin:7.50
CAGE cerebrum:0.18 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:2.81 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.31 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:11.30 ovary:- testis:30.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:- salivary:-
GeneChip uterus:7.69 placenta:7.59 prostate:7.36 ovary:7.79 testis:8.17 heart:8.23 muscle:7.91 esophagus:7.76 stomach:7.91 intestine:8.01 colon:8.04 liver/hepato:8.12 lung:7.76 bladder:- kidney:8.17 pituitary:8.39 thyroid/parathyroid:7.93 adrenal gland:7.86 pancreas:8.44 breast:7.57 salivary:7.82
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:1.63 ovary:2.31 testis:2.52 heart:0.41 muscle:0.32 esophagus:- stomach:- intestine:- colon:1.91     liver/hepato:0.02        lung:0.39    bladder:- kidney:1.57 pituitary:- thyroid/parathyroid:2.77 adrenal gland:1.28 pancreas:- breast:0.30 salivary:-

Gene Information

IDs

Refseq ID NM_002088
Gene ID 2901
Unigene ID Hs.367799
Probe set ID 217509_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000105737
GTEx ID ENSG00000105737

Orthologous Gene

Mouse[1]  NM_008168
Rat[1]  NM_031508

Chromosomal Region

19q13.2  [42,502,477  -  42,569,957]

Gene Family (Interpro ID)

IPR001320  Ionotropic glutamate receptor
IPR001508  NMDA receptor

Link to Pubmed  (Pubmed ID)

1321949
7527545
8288598
9039653
9099808
9466455
9808460
11279111
12477932
12573530
14511640
15254951
16169070
16325263
18247129
19086053
19125103
19342380
21771265
23288040

Gene Ontology  (GO ID)

Biological Process

GO:0071333  cellular response to glucose stimulus
GO:0051649  establishment of localization in cell
GO:0043525  positive regulation of neuron apoptosis
GO:0006621  protein retention in ER lumen
GO:0043113  receptor clustering
GO:0060079  regulation of excitatory postsynaptic membrane potential
GO:0031630  regulation of synaptic vesicle fusion to presynaptic membrane
GO:0007268  synaptic transmission
GO:0035249  synaptic transmission, glutamatergic

Cellular Component

GO:0030054  cell junction
GO:0030425  dendrite
GO:0016021  integral to membrane
GO:0032983  kainate selective glutamate receptor complex
GO:0043204  perikaryon
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane
GO:0042734  presynaptic membrane
GO:0043195  terminal button

Molecular Function

GO:0005234  extracellular-glutamate-gated ion channel activity
GO:0042802  identical protein binding
GO:0015277  kainate selective glutamate receptor activity
GO:0030165  PDZ domain binding
GO:0017124  SH3 domain binding