PYD and CARD domain containing

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Synonym

PYD and CARD domain containing, Target of methylation-induced silencing 1, TMS1, MGC10332, PYCARD, ASC, hASC, CARD5, PYD and CARD domain-containing protein, Caspase recruitment domain-containing protein 5

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:23.50 artery/aorta:- vein:133.30 lymphnode:30.30 peripheral blood:18.20 spleen:- thymus:- bone marrow:19.70 adipose:- bone:- skin:4.80
GeneChip cerebrum:4.75 cerebellum:4.95 brain stem:5.13 corpus callosum/glia:5.48 pineal gland:- peripheral nerve:5.34 spine:5.57 retina:- eye:- artery/aorta:5.84 vein:5.56 lymphnode:7.33 peripheral blood:- spleen:7.02 thymus:6.84 bone marrow:7.56 adipose:6.44 bone:- skin:7.85
CAGE cerebrum:1.65 cerebellum:- brain stem:2.38 corpus callosum/glia:2.82 pineal gland:0.98 peripheral nerve:- spine:2.30 retina:- eye:- artery/aorta:2.74 vein:3.62 lymphnode:4.14 peripheral blood:- spleen:4.28 thymus:3.67 bone marrow:- adipose:3.30 bone:- skin:-
RNA-seq cerebrum:0.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.27 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.99 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:14.60 prostate:33.80 ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:17     liver/hepato:-        lung:34.20    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:5.83 placenta:5 prostate:5.81 ovary:6.25 testis:4.42 heart:5.23 muscle:4.78 esophagus:7.43 stomach:5.85 intestine:6.65 colon:7.29 liver/hepato:5.24 lung:7.20 bladder:- kidney:4.65 pituitary:4.88 thyroid/parathyroid:5.37 adrenal gland:5.24 pancreas:5.43 breast:7.27 salivary:5.89
CAGE uterus:2.91 placenta:2.70 prostate:3.27 ovary:2.82 testis:2.03 heart:2.33 muscle:1.38 esophagus:3.59 stomach:- intestine:4.19 colon:4.21     liver/hepato:2.68    lung:3.80 bladder:2.73 kidney:2.62 pituitary:1.27 thyroid/parathyroid:2.54 adrenal gland:- pancreas:2.66 breast:3.02 salivary:3.29
RNA-seq uterus:- placenta:- prostate:3.70 ovary:3.30 testis:3.22 heart:1.40 muscle:1.23 esophagus:- stomach:- intestine:- colon:3.24     liver/hepato:1.97        lung:3.59    bladder:- kidney:2.18 pituitary:- thyroid/parathyroid:2.19 adrenal gland:4.65 pancreas:- breast:3.30 salivary:-

Gene Information

IDs

Refseq ID NM_013258
Gene ID 29108
Unigene ID Hs.499094
Probe set ID 221666_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000103490
GTEx ID ENSG00000103490

Orthologous Gene

Mouse[2]  NM_023258
Rat[1]  NM_172322

Chromosomal Region

16p11.2  [31,212,807  -  31,214,313]

Gene Family (Interpro ID)

IPR001315  Caspase Recruitment
IPR011029  DEATH-like
IPR004020  Pyrin

Link to Pubmed  (Pubmed ID)

10567338
10847592
11103776
11103777
11250163
11374873
11498534
11733524
11786556
11967258
12019269
12054656
12191486
12477932
12486103
12553049
12615073
12646168
12656673
12776200
12800194
12949795
14499617
14634131
14643031
14702039
14730312
14985395
15020601
15030775
15041718
15456791
15489334
15641782
15701651
16037825
16189514
16425203
16585594
16715133
16777061
16848908
16964285
16982856
17048097
17178784
17339483
17418785
17599361
17964261
17986858
18263805
18311798
18348116
18701507
18791131
18945969
19158675
19158676
19158679
19201894
19223547
19234215
19258216
19324871
19443857
19494289
19636848
19661336
19759015
19759850
20020448
20140741
20148899
20500518
20808838
20926535
21036703
21058222
21104989
21270336
21487011
21832064
21890473
22230750
22286270
22295065
22732093
22931929
22934972
23064206
23066025
23090995
23110696
23209292
23839215
24169962
24407287
24630722

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0002218  activation of innate immune response
GO:0071347  cellular response to interleukin-1
GO:0071222  cellular response to lipopolysaccharide
GO:0071356  cellular response to tumor necrosis factor
GO:0050829  defense response to Gram-negative bacterium
GO:0051607  defense response to virus
GO:0042771  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0006917  induction of apoptosis
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0032611  interleukin-1 beta production
GO:0001773  myeloid dendritic cell activation
GO:0002277  myeloid dendritic cell activation during immune response
GO:0043124  negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032688  negative regulation of interferon-beta production
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0030838  positive regulation of actin filament polymerization
GO:0042104  positive regulation of activated T cell proliferation
GO:0002821  positive regulation of adaptive immune response
GO:0002588  positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0043065  positive regulation of apoptosis
GO:0043280  positive regulation of caspase activity
GO:0090197  positive regulation of chemokine secretion
GO:0002230  positive regulation of defense response to virus by host
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0032729  positive regulation of interferon-gamma production
GO:0050718  positive regulation of interleukin-1 beta secretion
GO:0032755  positive regulation of interleukin-6 production
GO:0046330  positive regulation of JNK cascade
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0050766  positive regulation of phagocytosis
GO:0090200  positive regulation of release of cytochrome c from mitochondria
GO:0050870  positive regulation of T cell activation
GO:0051091  positive regulation of transcription factor activity
GO:0032760  positive regulation of tumor necrosis factor production
GO:0006508  proteolysis
GO:0031647  regulation of protein stability
GO:0032314  regulation of Rac GTPase activity
GO:0010803  regulation of tumor necrosis factor-mediated signaling pathway
GO:0007165  signal transduction
GO:0033209  tumor necrosis factor-mediated signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0005576  extracellular region
GO:0008385  IkappaB kinase complex
GO:0005739  mitochondrion
GO:0005634  nucleus

Molecular Function

GO:0008656  caspase activator activity
GO:0004197  cysteine-type endopeptidase activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0032090  Pyrin domain binding