TANK-binding kinase 1

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Synonym

T2K, TANK-binding kinase 1, NAK, FLJ11330, TBK1, Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:42.70

cerebellum:25.20

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:61.30

spine:224.60

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:70.80

peripheral blood:36.40

spleen:18.90

thymus:25.80

bone marrow:-

adipose:-

bone:25.60

skin:48

GeneChip

cerebrum:7.26

cerebellum:7.28

brain stem:7.36

corpus callosum/glia:7.23

pineal gland:-

peripheral nerve:7.23

spine:7.07

retina:-

eye:-

artery/aorta:6.71

vein:6.77

lymphnode:7.31

peripheral blood:-

spleen:7.55

thymus:6.03

bone marrow:7.21

adipose:7.19

bone:-

skin:6.79

CAGE

cerebrum:3.25

cerebellum:-

brain stem:3.50

corpus callosum/glia:2.82

pineal gland:3.70

peripheral nerve:-

spine:3.55

retina:-

eye:-

artery/aorta:3.12

vein:3.12

lymphnode:2.87

peripheral blood:-

spleen:3.61

thymus:1.77

bone marrow:-

adipose:3.43

bone:-

skin:-

RNA-seq

cerebrum:3.45

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.37

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.88

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:36.40

prostate:78.90

ovary:-

testis:134.10

heart:51.10

muscle:20.10

esophagus:-

stomach:-

intestine:64.80

colon:33.90

liver/hepato:31.70

lung:39.10

bladder:-

kidney:72.80

pituitary:116

thyroid/parathyroid:-

adrenal gland:-

pancreas:26.70

breast:46.50

salivary:-

GeneChip

uterus:7.38

placenta:8.32

prostate:7.46

ovary:7.38

testis:7.92

heart:7.05

muscle:7.15

esophagus:7.09

stomach:7.20

intestine:7.12

colon:6

liver/hepato:7.21

lung:7.34

bladder:-

kidney:6.60

pituitary:7.13

thyroid/parathyroid:6.92

adrenal gland:7.29

pancreas:5.84

breast:7.29

salivary:6.59

CAGE

uterus:3.28

placenta:4.03

prostate:3.28

ovary:3.21

testis:3.26

heart:3.15

muscle:2.70

esophagus:3.16

stomach:-

intestine:3.48

colon:3.16

liver/hepato:3.27

lung:3.47

bladder:3.35

kidney:3.13

pituitary:3.75

thyroid/parathyroid:2.99

adrenal gland:-

pancreas:2.18

breast:3.43

salivary:2.57

RNA-seq

uterus:-

placenta:-

prostate:3.39

ovary:3.52

testis:4.23

heart:2.72

muscle:3.18

esophagus:-

stomach:-

intestine:-

colon:3.02

liver/hepato:3.11

lung:4.13

bladder:-

kidney:3.49

pituitary:-

thyroid/parathyroid:3.62

adrenal gland:3.75

pancreas:-

breast:2.95

salivary:-

IDs

Refseq ID	NM_013254
Gene ID	29110
Unigene ID	Hs.505874
Probe set ID	218520_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000183735
GTEx ID	ENSG00000183735

Orthologous Gene

Mouse[2]	NM_019786
Rat[1]	NM_001106786

Chromosomal Region

12q14.2 [64,845,660 - 64,895,888]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0050830	defense response to Gram-positive bacterium
GO:0051607	defense response to virus
GO:0007249	I-kappaB kinase/NF-kappaB cascade
GO:0006954	inflammatory response
GO:0045087	innate immune response
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0010629	negative regulation of gene expression
GO:0032480	negative regulation of type I interferon production
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032727	positive regulation of interferon-alpha production
GO:0045359	positive regulation of interferon-beta biosynthetic process
GO:0032728	positive regulation of interferon-beta production
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0032481	positive regulation of type I interferon production
GO:0009615	response to virus
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0002224	toll-like receptor signaling pathway
GO:0032606	type I interferon production
GO:0019048	virus-host interaction

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010008	endosome membrane

Molecular Function

GO:0005524	ATP binding
GO:0003676	nucleic acid binding
GO:0051219	phosphoprotein binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity

TANK-binding kinase 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function