protein disulfide isomerase family A, member 3

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Synonym

Protein disulfide-isomerase A3 precursor, protein disulfide isomerase-associated 3, protein disulfide isomerase family A, member 3, 58 kDa glucose-regulated protein, GRP57, ERp57, Disulfide isomerase ER-60, ERP60, GRP58, HsT17083, 58 kDa microsomal protein, ERp61, PDIA3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:109 cerebellum:75.60 brain stem:- corpus callosum/glia:379.10 pineal gland:296.70 peripheral nerve:276 spine:- retina:118.60 eye:135.20 artery/aorta:299.80 vein:- lymphnode:202.20 peripheral blood:91.10 spleen:113.40 thymus:51.50 bone marrow:98.40 adipose:80.70 bone:230.30 skin:518.40
GeneChip cerebrum:8.09 cerebellum:7.74 brain stem:8.37 corpus callosum/glia:8.45 pineal gland:- peripheral nerve:8.71 spine:8.53 retina:- eye:- artery/aorta:8.84 vein:9 lymphnode:8.79 peripheral blood:- spleen:9.14 thymus:9.10 bone marrow:8.65 adipose:8.74 bone:- skin:8.93
CAGE cerebrum:4.91 cerebellum:- brain stem:5.05 corpus callosum/glia:5.15 pineal gland:5.15 peripheral nerve:- spine:5.04 retina:- eye:- artery/aorta:5.81 vein:5.32 lymphnode:5.82 peripheral blood:- spleen:5.78 thymus:5.17 bone marrow:- adipose:5.39 bone:- skin:-
RNA-seq cerebrum:4.87 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.60 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.67 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:227.80 placenta:375.20 prostate:146.40 ovary:37.30 testis:168.70 heart:178.80 muscle:80.40 esophagus:- stomach:934.70 intestine:226.80 colon:288.30     liver/hepato:190        lung:146.60    bladder:251.20 kidney:218.30 pituitary:116 thyroid/parathyroid:655 adrenal gland:253.90 pancreas:533.50 breast:223 salivary:328.40
GeneChip uterus:9.53 placenta:10.13 prostate:10.45 ovary:9.66 testis:9.08 heart:8.70 muscle:6.70 esophagus:9.03 stomach:9.47 intestine:9.28 colon:9.25 liver/hepato:9.09 lung:9.31 bladder:- kidney:8.90 pituitary:9.90 thyroid/parathyroid:10.17 adrenal gland:9.06 pancreas:9.57 breast:9.01 salivary:9.33
CAGE uterus:5.55 placenta:6.24 prostate:5.62 ovary:5.68 testis:5.40 heart:5.74 muscle:4.41 esophagus:5.23 stomach:- intestine:5.89 colon:5.58     liver/hepato:7.09    lung:5.77 bladder:5.30 kidney:5.84 pituitary:5.99 thyroid/parathyroid:6.77 adrenal gland:- pancreas:6.29 breast:6.04 salivary:6.04
RNA-seq uterus:- placenta:- prostate:5.77 ovary:6.47 testis:6.50 heart:4.33 muscle:3.76 esophagus:- stomach:- intestine:- colon:6.28     liver/hepato:7.43        lung:6.25    bladder:- kidney:6.56 pituitary:- thyroid/parathyroid:7.28 adrenal gland:6.32 pancreas:- breast:5.85 salivary:-

Gene Information

IDs

Refseq ID NM_005313
Gene ID 2923
Unigene ID Hs.591095
Probe set ID 208612_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000167004
GTEx ID ENSG00000167004

Orthologous Gene

Mouse[1]  NM_007952
Rat [0]  

Chromosomal Region

15q15.3  [44,038,590  -  44,065,477]

Gene Family (Interpro ID)

IPR005788  Disulphide isomerase
IPR005792  Protein disulphide isomerase
IPR013766  Thioredoxin domain
IPR012335  Thioredoxin fold
IPR017936  Thioredoxin-like
IPR012336  Thioredoxin-like fold

Link to Pubmed  (Pubmed ID)

1286667
1286669
1602151
3398923
7487104
8529662
8624847
8687406
8805302
8974399
9150946
9150948
9153243
9205111
9399589
9545232
10436013
10508608
10929008
11832422
11840567
11842220
12032078
12047747
12052826
12060494
12162574
12218051
12218052
12235131
12239218
12477932
12517784
12643545
12665801
12938929
14644099
14732712
14871896
14871899
15236594
15328618
15451439
15489334
15606899
15644496
15862831
15896298
15952740
16002696
16130169
16182193
16193070
16236267
16303743
16341674
16368681
16428306
16940051
16962936
17055437
17061245
17081065
17150345
17170699
17188166
17301129
17456022
17467700
17704119
17728248
17822402
17848102
17964282
18029348
18039656
18303019
18650385
18976975
19054761
19064571
19119025
19135240
19199708
19411306
19701894
19714814
19995400
19995546
20029959
20035634
20064506
20360068
20458450
20506389
20596667
20596672
20802462
21139048
21252943
21319273
21321085
21362330
21598303
21832049
21837552
21840908
21890473
21917082
21963094
21996511
22168334
22190034
22207023
22230366
22266712
22304920
22322599
22484374
22503978
22536838
22863883
22923333
22939629
22944692
23000965
23206338
23226417
23255428
23587917
23625662
23752268
23781031
23827315
23862649
23874603
23956138
23957851
24030382
24040290
24188822
24457600
24583282
24599957
24815697
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0042590  antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474  antigen processing and presentation of peptide antigen via MHC class I
GO:0045454  cell redox homeostasis
GO:0044267  cellular protein metabolic process
GO:0006662  glycerol ether metabolic process
GO:0043065  positive regulation of apoptosis
GO:0043687  post-translational protein modification
GO:0018279  protein amino acid N-linked glycosylation via asparagine
GO:0006457  protein folding
GO:0006606  protein import into nucleus
GO:0006621  protein retention in ER lumen
GO:0007165  signal transduction

Cellular Component

GO:0009986  cell surface
GO:0005783  endoplasmic reticulum
GO:0005788  endoplasmic reticulum lumen
GO:0042470  melanosome

Molecular Function

GO:0004197  cysteine-type endopeptidase activity
GO:0009055  electron carrier activity
GO:0004629  phospholipase C activity
GO:0005515  protein binding
GO:0003756  protein disulfide isomerase activity
GO:0015035  protein disulfide oxidoreductase activity